PMID- 32473477
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 577
DP  - 2020 Oct 1
TI  - Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles 
      for chemo-photothermal therapy against bacterial biofilms.
PG  - 66-74
LID - S0021-9797(20)30670-6 [pii]
LID - 10.1016/j.jcis.2020.05.067 [doi]
AB  - Bacterial biofilm represents a protected mode of bacterial growth that 
      significantly enhances the resistance to antibiotics. Poly lactic-co-glycolic 
      acid (PLGA)-based nanoparticle delivery systems have been intensively 
      investigated to combat the bacterial biofilms-associated infections. However, 
      some drawbacks associated with current PLGA-based nanoformulations (e.g. the 
      relatively low drug loading capability, premature burst release and/or 
      incapability of on-demand release of cargos at the site of action) restrict the 
      transition from the lab research to the clinical applications. One potent 
      strategy to overcome the above-mentioned limitations is exploiting the unique 
      properties of carbon quantum dots (CQDs) and combining CQDs with the conventional 
      PLGA nanoparticles. In the present study, the CQDs were innovatively incorporated 
      into PLGA nanoparticles by using a microfluidic method. The resulting CQD-PLGA 
      hybrid nanoparticles presented good loading capability of azithromycin (a 
      macrolide antibiotic, AZI) and tobramycin (an aminoglycoside antibiotic, TOB), 
      and stimuli-responsive release of the cargos upon laser irradiation. 
      Consequently, AZI-loaded CQD-PLGA hybrid nanoparticles showed 
      chemo-photothermally synergistic anti-biofilm effects against P. aeruginosa 
      biofilms. Additionally, the CQD-PLGA hybrid nanoparticles demonstrated good 
      biocompatibility with the eukaryotic cells. Overall, the proof-of-concept of 
      CQD-PLGA hybrid nanoparticles may open a new possibility in chemo-photothermal 
      therapy against bacterial biofilms.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Huang, Zheng
AU  - Huang Z
AD  - Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 
      Copenhagen O, Denmark.
FAU - Zhou, Tongchang
AU  - Zhou T
AD  - Department of Health Technology, Technical University of Denmark, Building 220, 
      Soltofts Plads, DK-2800 Lyngby, Denmark.
FAU - Yuan, Yuan
AU  - Yuan Y
AD  - Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 
      Copenhagen O, Denmark.
FAU - Natalie Klodzinska, Sylvia
AU  - Natalie Klodzinska S
AD  - Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 
      Copenhagen O, Denmark; Center for Biopharmaceuticals and Biobarriers in Drug 
      Delivery, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen O, 
      Denmark.
FAU - Zheng, Tao
AU  - Zheng T
AD  - Department of Health Technology, Technical University of Denmark, Building 220, 
      Soltofts Plads, DK-2800 Lyngby, Denmark.
FAU - Sternberg, Claus
AU  - Sternberg C
AD  - Department of Biotechnology and Biomedicine, Technical University of Denmark, 
      Building 221, Soltofts Plads, DK-2800 Lyngby, Denmark.
FAU - Morck Nielsen, Hanne
AU  - Morck Nielsen H
AD  - Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 
      Copenhagen O, Denmark.
FAU - Sun, Yi
AU  - Sun Y
AD  - Department of Health Technology, Technical University of Denmark, Building 220, 
      Soltofts Plads, DK-2800 Lyngby, Denmark. Electronic address: suyi@dtu.dk.
FAU - Wan, Feng
AU  - Wan F
AD  - Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 
      Copenhagen O, Denmark; Center for Biopharmaceuticals and Biobarriers in Drug 
      Delivery, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen O, 
      Denmark. Electronic address: feng.wan@sund.ku.dk.
LA  - eng
PT  - Journal Article
DEP - 20200523
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Drug Carriers)
RN  - 0 (Glycolates)
RN  - 0 (Glycols)
RN  - 0WT12SX38S (glycolic acid)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Biofilms
MH  - Carbon
MH  - Drug Carriers
MH  - Glycolates
MH  - Glycols
MH  - *Nanoparticles
MH  - Photothermal Therapy
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - *Quantum Dots
OTO - NOTNLM
OT  - Azithromycin
OT  - Bacterial biofilms
OT  - Carbon quantum dots
OT  - Chemo-photothermal therapy
OT  - PLGA nanoparticles
OT  - Tobramycin
EDAT- 2020/05/31 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/05/31 06:00
PHST- 2020/04/16 00:00 [received]
PHST- 2020/05/11 00:00 [revised]
PHST- 2020/05/17 00:00 [accepted]
PHST- 2020/05/31 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/05/31 06:00 [entrez]
AID - S0021-9797(20)30670-6 [pii]
AID - 10.1016/j.jcis.2020.05.067 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2020 Oct 1;577:66-74. doi: 10.1016/j.jcis.2020.05.067. 
      Epub 2020 May 23.