PMID- 32473554
OWN - NLM
STAT- MEDLINE
DCOM- 20210610
LR  - 20210610
IS  - 1532-8198 (Electronic)
IS  - 1092-9134 (Linking)
VI  - 46
DP  - 2020 Jun
TI  - Complexities in the diagnosis of large B-cell lymphomas, classic Hodgkin 
      lymphomas and overlapping peripheral T-cell lymphomas simplified: An 
      evidence-based guide.
PG  - 151534
LID - S1092-9134(20)30075-7 [pii]
LID - 10.1016/j.anndiagpath.2020.151534 [doi]
AB  - The diagnosis of a large B-cell lymphoma and classic Hodgkin lymphoma (CHL) is 
      often straightforward. However, in select circumstances, these simple diagnoses 
      can be quite complex. In part, diagnostic difficulty may be due to uncertainty in 
      the evaluation of morphologic and immunophenotypic features along a biologic 
      continuum, or alternatively arise from uncertainty in predicting the behavior and 
      outcomes of patients. Here, we systematically discuss and review areas of 
      diagnostic difficulty in the diagnosis of large B-cell lymphomas (LBCL), classic 
      Hodgkin lymphomas (CHL) and peripheral T-cell lymphomas (PTCL). We provide 
      careful data-driven analyses and evidence-based approaches to help guide 
      pathologists and clinicians. We discuss: 1) marginal zone lymphomas with 
      increased large cells versus diffuse large B-cell lymphoma (DLBCL), 2) chronic 
      lymphocytic leukemia with expanded proliferation centers versus diffuse large 
      B-cell lymphoma (DLBCL), 3) chronic lymphocytic leukemia with 
      Hodgkin/Reed-Sternberg-like cells versus CHL arising from chronic lymphocytic 
      leukemia, 4) complex cases of follicular lymphoma versus DLBCL, 5) PTCL with 
      large B-cell proliferations versus PTCL with LBCL, 6) PTCL with 
      Hodgkin/Reed-Sternberg-like cells versus CHL, and finally 7) blastoid/pleomorphic 
      mantle cell lymphoma versus DLBCL. Our evidence and data driven approach may 
      serve as a useful diagnostic guide.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Wen, Kwun Wah
AU  - Wen KW
AD  - Department of Pathology, University of California, San Francisco, CA 94143, 
      United States of America. Electronic address: Kwun.Wen@ucsf.edu.
FAU - Fakhri, Bita
AU  - Fakhri B
AD  - Department of Medicine, University of California, San Francisco, CA 94143, United 
      States of America. Electronic address: Bita.Fakhri@ucsf.edu.
FAU - Menke, Joshua
AU  - Menke J
AD  - Department of Pathology, University of California, San Francisco, CA 94143, 
      United States of America. Electronic address: Joshua.Menke@ucsf.edu.
FAU - Ruiz-Cordero, Roberto
AU  - Ruiz-Cordero R
AD  - Department of Pathology, University of California, San Francisco, CA 94143, 
      United States of America. Electronic address: Roberto.Ruiz-Cordero@ucsf.edu.
FAU - Gill, Ryan M
AU  - Gill RM
AD  - Department of Pathology, University of California, San Francisco, CA 94143, 
      United States of America. Electronic address: Ryan.Gill@ucsf.edu.
FAU - Ohgami, Robert S
AU  - Ohgami RS
AD  - Department of Pathology, University of California, San Francisco, CA 94143, 
      United States of America. Electronic address: Robert.Ohgami@ucsf.edu.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20200515
PL  - United States
TA  - Ann Diagn Pathol
JT  - Annals of diagnostic pathology
JID - 9800503
SB  - IM
MH  - Evidence-Based Medicine
MH  - Hodgkin Disease/*diagnosis
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnosis
MH  - Lymphoma, T-Cell, Peripheral/*diagnosis
OTO - NOTNLM
OT  - Classic Hodgkin lymphoma
OT  - Large B-cell lymphoma
OT  - Low grade B-cell lymphoma
OT  - T-cell lymphoma
OT  - Transformation
COIS- Declaration of competing interest None declared.
EDAT- 2020/05/31 06:00
MHDA- 2021/06/11 06:00
CRDT- 2020/05/31 06:00
PHST- 2020/04/28 00:00 [received]
PHST- 2020/05/01 00:00 [accepted]
PHST- 2020/05/31 06:00 [pubmed]
PHST- 2021/06/11 06:00 [medline]
PHST- 2020/05/31 06:00 [entrez]
AID - S1092-9134(20)30075-7 [pii]
AID - 10.1016/j.anndiagpath.2020.151534 [doi]
PST - ppublish
SO  - Ann Diagn Pathol. 2020 Jun;46:151534. doi: 10.1016/j.anndiagpath.2020.151534. 
      Epub 2020 May 15.