PMID- 32473848
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 1437-7780 (Electronic)
IS  - 1341-321X (Linking)
VI  - 26
IP  - 9
DP  - 2020 Sep
TI  - Total and double-stranded DNA-specific immunoglobulin E in bronchoalveolar lavage 
      fluid of children with human adenovirus pneumonia.
PG  - 986-991
LID - S1341-321X(20)30150-1 [pii]
LID - 10.1016/j.jiac.2020.04.024 [doi]
AB  - BACKGROUND: Some antibodies and autoreactive antibodies are associated with the 
      severity of infectious diseases. The roles of humoral responses to lung 
      inflammation in children with human adenovirus (HAdVs) pneumonia remain unknown. 
      PATIENTS AND METHODS: A retrospective study was done to compare plasma 
      immunoglobulin E (IgE) levels between HAdVs pneumonia patients and healthy 
      children by searching the electronic medical record system of Guangzhou Women and 
      Children's Medical Center. Then, a prospective study was performed for children 
      with HAdVs pneumonia who needed flexible bronchoscopy for examination and 
      treatment purposes during July 2017 to July 2019. We examined the IgE and 
      autoreactive IgE levels in plasma and bronchoalveolar lavage fluid (BALF) of 
      these children to explore their role in HAdVs pneumonia. RESULTS: A significantly 
      higher level of IgE was found in plasma from children hospitalized with HAdVs 
      pneumonia compared with that from healthy children in the same age range. 
      Furthermore, the levels of IgE, double-stranded DNA (dsDNA), and double-stranded 
      DNA-specific immunoglobulin E (dsDNA-IgE) in BALF were increased compared to 
      plasma in children with HAdVs pneumonia. The levels of IgE, dsDNA, and dsDNA-IgE 
      in BALF were significantly higher in the severe group compared to the non-severe 
      group. The ability of IgE in BALF to recognize dsDNA was verified by the ELISPOT 
      test. CONCLUSIONS: Our findings indicate that IgE and dsDNA-IgE in BALF may 
      contribute to lung injury caused by HAdVs, especially in severe cases. Elevated 
      dsDNA-IgE may serve as an indicator of severity in children with HAdVs pneumonia.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Yang, Di-Yuan
AU  - Yang DY
AD  - Department of Respiration, Guangzhou Women and Children's Medical Centre, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Lu, Bing-Tai
AU  - Lu BT
AD  - Guangzhou Institute of Paediatrics, Guangzhou Women and Children's Medical 
      Centre, Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Shi, Ting-Ting
AU  - Shi TT
AD  - Department of Respiration, Guangzhou Women and Children's Medical Centre, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Fan, Hui-Feng
AU  - Fan HF
AD  - Department of Respiration, Guangzhou Women and Children's Medical Centre, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Zhang, Dong-Wei
AU  - Zhang DW
AD  - Department of Respiration, Guangzhou Women and Children's Medical Centre, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Huang, Li
AU  - Huang L
AD  - Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, 
      Guangzhou Medical University, Guangzhou, China.
FAU - Lu, Gen
AU  - Lu G
AD  - Department of Respiration, Guangzhou Women and Children's Medical Centre, 
      Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: 
      lugen5663330@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20200528
PL  - Netherlands
TA  - J Infect Chemother
JT  - Journal of infection and chemotherapy : official journal of the Japan Society of 
      Chemotherapy
JID - 9608375
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Adenoviruses, Human
MH  - Bronchoalveolar Lavage Fluid
MH  - Child
MH  - DNA
MH  - Female
MH  - Humans
MH  - Immunoglobulin E
MH  - *Pneumonia
MH  - Prospective Studies
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Children
OT  - Double-stranded DNA
OT  - Human adenovirus pneumonia
OT  - Immunoglobulin E
COIS- Declaration of Competing Interest All authors report no conflicts of interest.
EDAT- 2020/06/01 06:00
MHDA- 2021/06/25 06:00
CRDT- 2020/06/01 06:00
PHST- 2019/12/18 00:00 [received]
PHST- 2020/04/12 00:00 [revised]
PHST- 2020/04/26 00:00 [accepted]
PHST- 2020/06/01 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2020/06/01 06:00 [entrez]
AID - S1341-321X(20)30150-1 [pii]
AID - 10.1016/j.jiac.2020.04.024 [doi]
PST - ppublish
SO  - J Infect Chemother. 2020 Sep;26(9):986-991. doi: 10.1016/j.jiac.2020.04.024. Epub 
      2020 May 28.