PMID- 32473928
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 223
DP  - 2020 Sep 1
TI  - Short-term interval exercise suppresses acylated ghrelin and hunger during 
      caloric restriction in women with obesity.
PG  - 112978
LID - S0031-9384(20)30292-4 [pii]
LID - 10.1016/j.physbeh.2020.112978 [doi]
AB  - Caloric restriction is suggested to increase hunger, in part, through complex 
      interactions of hormones and behavior that contribute to challenges in long-term 
      weight loss. Although intense exercise may attenuate appetite, no data exist 
      testing the effects of interval exercise (INT) during a low-calorie diet (LCD) on 
      appetite regulation. We hypothesized that LCD+INT would favorably influence 
      satiety when compared with an energy-deficit matched LCD in women with obesity. 
      Twenty-six women with obesity (47.3+/-2.4 yrs; 37.3 +/- 1.2 kg/m(2)) were randomized 
      to either LCD (n = 13; mixed meals of ~1200 kcal/d) or LCD+INT (n = 13; 60 min/d 
      of supervised interval exercise at 90% HRpeak for 3 min and 50% HRpeak for 3 min) 
      for 2 weeks. An additional 350kcal (shake) was provided to LCD+INT individuals 
      post-exercise to equate energy availability between groups. Total PYY, acylated 
      ghrelin and des-ghrelin were measured at 0, 30 and 60 min of a 75g OGTT before 
      and after the intervention. Visual analog scales were also administered at 0 and 
      120 min of the OGTT to assess appetite perception. Food logs were recorded prior 
      to and during the intervention to ensure caloric intake compliance. Compared with 
      pre-intervention conditions, both interventions decreased food intake (P = 0.001) 
      and body fat (P < 0.01). There was no effect on fasting PYY, but both LCD and 
      LCD+INT increased post-prandial PYY iAUC (P < 0.001) relative to 
      pre-intervention. LCD+INT maintained fasting acylated ghrelin (P = 0.06) and 
      suppressed post-prandial acylated ghrelin iAUC (P = 0.04) compared to LCD. 
      Neither intervention impacted circulating des- ghrelin before or following the 
      OGTT. Interestingly, LCD+INT attenuated fasting hunger and maintained fullness 
      compared with LCD (P = 0.05 and P = 0.06, respectively). Taken together, interval 
      exercise favors acylated ghrelin suppression and perception of hunger during a 
      LCD in women with obesity.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Malin, Steven K
AU  - Malin SK
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States; Division of Endocrinology & Metabolism, University of Virginia, 
      Charlottesville, VA, United States; Robert M. Berne Cardiovascular Research 
      Center, University of Virginia, Charlottesville, VA, United States. Electronic 
      address: skm6n@virginia.edu.
FAU - Heiston, Emily M
AU  - Heiston EM
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Gilbertson, Nicole M
AU  - Gilbertson NM
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
FAU - Eichner, Natalie Z M
AU  - Eichner NZM
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA, United 
      States.
LA  - eng
GR  - R01 HL130296/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200529
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Ghrelin)
RN  - 106388-42-5 (Peptide YY)
SB  - IM
MH  - Appetite
MH  - *Caloric Restriction
MH  - Energy Intake
MH  - Exercise
MH  - Female
MH  - *Ghrelin
MH  - Humans
MH  - Hunger
MH  - Obesity/therapy
MH  - Peptide YY
OTO - NOTNLM
OT  - Appetite
OT  - Diet
OT  - Hunger
OT  - Physical Activity
OT  - Weight management
COIS- Declaration of Competing Interest None to disclose.
EDAT- 2020/06/01 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/06/01 06:00
PHST- 2019/10/09 00:00 [received]
PHST- 2020/04/01 00:00 [revised]
PHST- 2020/05/20 00:00 [accepted]
PHST- 2020/06/01 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/06/01 06:00 [entrez]
AID - S0031-9384(20)30292-4 [pii]
AID - 10.1016/j.physbeh.2020.112978 [doi]
PST - ppublish
SO  - Physiol Behav. 2020 Sep 1;223:112978. doi: 10.1016/j.physbeh.2020.112978. Epub 
      2020 May 29.