PMID- 32476746
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 0971-3026 (Print)
IS  - 1998-3808 (Electronic)
IS  - 0970-2016 (Linking)
VI  - 30
IP  - 1
DP  - 2020 Jan-Mar
TI  - Chemotherapy-induced pulmonary complications in cancer: Significance of 
      clinicoradiological correlation.
PG  - 20-26
LID - 10.4103/ijri.IJRI_178_19 [doi]
AB  - Chemotherapy while revolutionizing cancer management by improving survival and 
      quality of life; is also associated with several adverse effects. Lung is the 
      most common organ affected in chemotherapy-related complications, due to either 
      drug toxicity or more commonly due to infections caused by immunosuppression and 
      less commonly due to immune-mediated injury. Radiology, when used in combination 
      with clinical and lab data, can help reach the specific diagnosis or narrow down 
      the differentials. The common radiological patterns of drug toxicity include 
      pulmonary interstitial and airway infiltrates, diffuse alveolar damage, 
      nonspecific interstitial pneumonia, eosinophilic pneumonia, cryptogenic 
      organizing pneumonia, pulmonary hemorrhage, edema and hypertension. Cancer 
      patients are immunosuppressed due to the underlying malignancy itself or due to 
      therapy and are prone to a gamut of opportunistic infections including viral, 
      bacterial, fungal and mycobacterial pathogens. Immune reconstitution inflammatory 
      syndrome (IRIS), a well-known complication in HIV, is now being increasingly 
      recognized in non-HIV patients with immunosuppression. Engraftment syndrome is 
      specifically seen following hematopoietic stem cell transplant during neutrophil 
      recovery phase. Pulmonary involvement is frequent, causing a radiological picture 
      of noncardiogenic pulmonary edema. Thus, radiology in combination with clinical 
      background and lab parameters helps in detecting and differentiating various 
      causes of pulmonary complications. This approach can help alter potentially toxic 
      treatment and initiate early treatment depending on the diagnosis.
CI  - Copyright: (c) 2020 Indian Journal of Radiology and Imaging.
FAU - Dhamija, Ekta
AU  - Dhamija E
AD  - Department of Radiodiagnosis, Dr B.R.A. Institute Rotary Cancer Hospital, All 
      India Institute of Medical Sciences, New Delhi, India.
FAU - Meena, Pankaj
AU  - Meena P
AD  - Department of Radiodiagnosis, Dr B.R.A. Institute Rotary Cancer Hospital, All 
      India Institute of Medical Sciences, New Delhi, India.
FAU - Ramalingam, Vidyasagar
AU  - Ramalingam V
AD  - Department of Radiodiagnosis, Dr B.R.A. Institute Rotary Cancer Hospital, All 
      India Institute of Medical Sciences, New Delhi, India.
FAU - Sahoo, Ranjeet
AU  - Sahoo R
AD  - Department of Medical Oncology, Dr B.R.A. Institute Rotary Cancer Hospital, All 
      India Institute of Medical Sciences, New Delhi, India.
FAU - Rastogi, Sameer
AU  - Rastogi S
AD  - Department of Medical Oncology, Dr B.R.A. Institute Rotary Cancer Hospital, All 
      India Institute of Medical Sciences, New Delhi, India.
FAU - Thulkar, Sanjay
AU  - Thulkar S
AD  - Department of Radiodiagnosis, Dr B.R.A. Institute Rotary Cancer Hospital, All 
      India Institute of Medical Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20200330
PL  - Germany
TA  - Indian J Radiol Imaging
JT  - The Indian journal of radiology & imaging
JID - 8503873
PMC - PMC7240883
OTO - NOTNLM
OT  - Chemotherapy
OT  - engraftment syndrome
OT  - pulmonary drug toxicity
OT  - pulmonary infections
COIS- There are no conflicts of interest.
EDAT- 2020/06/02 06:00
MHDA- 2020/06/02 06:01
PMCR- 2020/01/01
CRDT- 2020/06/02 06:00
PHST- 2019/04/14 00:00 [received]
PHST- 2019/10/23 00:00 [revised]
PHST- 2020/01/17 00:00 [accepted]
PHST- 2020/06/02 06:00 [entrez]
PHST- 2020/06/02 06:00 [pubmed]
PHST- 2020/06/02 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - IJRI-30-20 [pii]
AID - 10.4103/ijri.IJRI_178_19 [doi]
PST - ppublish
SO  - Indian J Radiol Imaging. 2020 Jan-Mar;30(1):20-26. doi: 10.4103/ijri.IJRI_178_19. 
      Epub 2020 Mar 30.