PMID- 32476894
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200722
IS  - 2532-179X (Electronic)
IS  - 1124-0490 (Print)
IS  - 1124-0490 (Linking)
VI  - 35
IP  - 2
DP  - 2018
TI  - Association of class II human leukocyte antigen (HLA) alleles with pulmonary 
      sarcoidosis.
PG  - 143-149
LID - 10.36141/svdld.v35i2.6455 [doi]
AB  - Background and objectives: Sarcoidosis is a systemic inflammatory disease of 
      unknown etiology that involves any part of the body, mainly the lungs and 
      thoracic lymph nodes. The clinical presentation is heterogeneous based on the 
      degree and extent of organ involvement. The existence of variable clinical 
      presentations and treatment responses suggest an important role of genetic 
      predisposition. In genetic studies, sarcoidosis was found to be associated with 
      several genes, but the strongest link was with HLA region. The aim of this study 
      was to investigate the association of HLA class II alleles with the extent and 
      course of disease in Turkish patients with sarcoidosis. Methods: The study 
      included 103 patients with sarcoidosis and 100 unrelated healthy controls. 
      HLA-DRB1 and HLA-DQB1 typing was performed by using Polymerase Chain 
      Reaction-Sequence Specific Priming (PCR-SSP) method at low resolution level. 
      Results: HLA-DRB1* and -DQB1* analysis revealed that while the frequency of 
      HLA-DRB1*01 was significantly higher in the control group, HLA-DRB1*13 and 
      -DQB1*06 alleles were more frequent in the sarcoidosis patients. When the 
      patients were grouped based on clinical outcome as remitters and non-remitters, 
      HLA-DRB1*10 allele was only detected in the remitters, whereas the frequency of 
      HLA-DQB1*06 allele was significantly higher in non-remitters. Conclusions: This 
      study supported the association of HLA alleles with sarcoidosis. In a 
      considerably high number of patients with Turkish origin, the frequency of 
      HLA-DRB1*13, -DRB1*10 and HLA-DQB1*06 alleles was significantly associated with 
      increased risk and clinical outcome. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 
      143-149).
CI  - Copyright: (c) 2018.
FAU - Esendagli, Dorina
AU  - Esendagli D
AD  - Hacettepe University School of Medicine, Department of Chest Diseases.
FAU - Ozmen, Fusun
AU  - Ozmen F
AD  - Department of Basic Oncology.
FAU - Koksal, Deniz
AU  - Koksal D
AD  - Hacettepe University School of Medicine, Department of Chest Diseases.
FAU - Onder, Sevgen
AU  - Onder S
AD  - Department of Pathology, Turkey.
FAU - Emri, Salih
AU  - Emri S
AD  - Hacettepe University School of Medicine, Department of Chest Diseases.
LA  - eng
PT  - Journal Article
DEP - 20180428
PL  - Italy
TA  - Sarcoidosis Vasc Diffuse Lung Dis
JT  - Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
JID - 9610928
PMC - PMC7170083
OTO - NOTNLM
OT  - HLA
OT  - genotyping
OT  - interstitial lung disease
OT  - pulmonary sarcoidosis
EDAT- 2018/01/01 00:00
MHDA- 2018/01/01 00:01
PMCR- 2018/01/01
CRDT- 2020/06/02 06:00
PHST- 2017/05/13 00:00 [received]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2020/06/02 06:00 [entrez]
PHST- 2018/01/01 00:00 [pubmed]
PHST- 2018/01/01 00:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - SVDLD-35-143 [pii]
AID - 10.36141/svdld.v35i2.6455 [doi]
PST - ppublish
SO  - Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(2):143-149. doi: 
      10.36141/svdld.v35i2.6455. Epub 2018 Apr 28.