PMID- 32477169 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220414 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 11 DP - 2020 TI - Anti-N-Methyl-D-Aspartate-Receptor Encephalitis: A 10-Year Follow-Up. PG - 245 LID - 10.3389/fpsyt.2020.00245 [doi] LID - 245 AB - BACKGROUND: Anti-N-methyl-D-aspartate-receptor (NMDA-R) encephalitis is an autoimmune disease of the brain first described in 2007. The aim of this paper is to present a 10-year follow-up case history. CASE PRESENTATION: The authors present the case of a 39-year-old female patient who developed an anti-NMDA-R encephalitis in 2009 with predominant severe catatonic symptoms. Anti-inflammatory therapy led to the disappearance of catatonic symptoms and was discontinued during the course of the disease. After acute therapy, the patient achieved an almost full recovery presenting with ongoing discrete symptoms of sensory overload, subtle cognitive deficits, and fatigue/reduced energy levels. The follow-up investigation in 2019 showed inconspicuous findings in laboratory diagnostics and magnetic resonance imaging. Electroencephalography (EEG) analysis using independent component analysis detected left hemispherical spike-wave complexes and intermittent slowing. Regarding the sensory overload and reduced energy level, the patient benefited from low-dose neuroleptics (risperidone, amisulpride). In terms of sensory overload associated with experiences of panic, cognitive deficits and coping with the disease, she improved with cognitive behavioral therapy (CBT). CONCLUSION: Anti-inflammatory treatment led to almost full recovery with persistent disappearance of catatonic symptoms; however, a dysexecutive syndrome led to ongoing relevant problems with good response to low-dose atypical neuroleptics and CBT. The patient had persistent EEG alterations that indicated continuing neuronal network instability. Therefore, the case demonstrates the importance of multidisciplinary outpatient treatment following acute therapy for anti-NMDA-R encephalitis in patients with ongoing psychiatric deficits. For the symptomatic treatment of executive dysfunctions, "classical" psychiatric treatment may be helpful in the course of the disease. CI - Copyright (c) 2020 Meixensberger, Tebartz van Elst, Schweizer, Maier, Pruss, Feige, Denzel, Runge, Nickel, Matysik, Venhoff, Domschke, Urbach, Perlov and Endres. FAU - Meixensberger, Sophie AU - Meixensberger S AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Tebartz van Elst, Ludger AU - Tebartz van Elst L AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Schweizer, Tina AU - Schweizer T AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Maier, Simon J AU - Maier SJ AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Pruss, Harald AU - Pruss H AD - Department of Neurology and Experimental Neurology, Charite - Universitatsmedizin Berlin, Berlin, Germany. AD - German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany. FAU - Feige, Bernd AU - Feige B AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Denzel, Dominik AU - Denzel D AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Runge, Kimon AU - Runge K AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Nickel, Kathrin AU - Nickel K AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Matysik, Miriam AU - Matysik M AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Venhoff, Nils AU - Venhoff N AD - Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Domschke, Katharina AU - Domschke K AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Centre for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Urbach, Horst AU - Urbach H AD - Department of Neuroradiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Perlov, Evgeniy AU - Perlov E AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Clinic for Psychiatry Luzern, St. Urban, Switzerland. FAU - Endres, Dominique AU - Endres D AD - Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. LA - eng PT - Case Reports DEP - 20200515 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC7242611 OTO - NOTNLM OT - anti-N-methyl-D-aspartate-receptor encephalitis OT - antibodies OT - catatonia OT - follow-up OT - long-term OT - neuroleptics OT - psychotherapy EDAT- 2020/06/02 06:00 MHDA- 2020/06/02 06:01 PMCR- 2020/05/15 CRDT- 2020/06/02 06:00 PHST- 2020/01/06 00:00 [received] PHST- 2020/03/12 00:00 [accepted] PHST- 2020/06/02 06:00 [entrez] PHST- 2020/06/02 06:00 [pubmed] PHST- 2020/06/02 06:01 [medline] PHST- 2020/05/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2020.00245 [doi] PST - epublish SO - Front Psychiatry. 2020 May 15;11:245. doi: 10.3389/fpsyt.2020.00245. eCollection 2020.