PMID- 32477356
OWN - NLM
STAT- MEDLINE
DCOM- 20210405
LR  - 20210519
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.
PG  - 881
LID - 10.3389/fimmu.2020.00881 [doi]
LID - 881
AB  - Characteristic of allergic asthma, CD4+Th2 lymphocytes secrete Th2 cytokines, 
      interleukin (IL)-4, IL-13, and IL-5 that mediate the inflammatory immune 
      response. Surface expression of CD2 and its ligand, CD58, is increased on the 
      monocytes and eosinophils of asthma patients, which correlate with elevated serum 
      IgE levels, suggesting that CD2 may contribute to allergic airway inflammation. 
      Using a murine model of asthma, we observed that house dust mice extract 
      (HDME)-exposed Balb/c mice have increased airway hyperresponsiveness (AHR), lung 
      inflammation, goblet cell hyperplasia, and elevated levels of Th2 cytokines in 
      the lungs, as well as increased serum IgE levels as compared to the control mice. 
      In contrast, with the exception of serum IgE levels, all the other parameters 
      were significantly reduced in HDME-treated Cd2(-/-) mice. Interestingly, Il13 but 
      not Il4 or Il5 gene expression in the lungs was dramatically decreased in 
      HDME-exposed Cd2(-/-) mice. Of note, the gene expression of IL-13 downstream 
      targets (Muc5b and Muc5ac) and high affinity IL-13Ralpha2 were upregulated in the 
      lungs of HDME-exposed Balb/c mice but were significantly reduced in HDME-exposed 
      Cd2(-/-) mice. Consistently, gene expression of microRNAs regulating mucin 
      production, inflammation, airway smooth muscle cell proliferation and IL-13 
      transcripts were increased in the lungs of HDME-exposed Cd2(-/-) mice. Given the 
      established role of IL-13 in promoting goblet cell hyperplasia, lung inflammation 
      and AHR in allergic asthma, our studies reveal a unique role for CD2 in the 
      regulation of Th2-associated allergic asthma.
CI  - Copyright (c) 2020 Hashem, Kammala, Thaxton, Griffin, Mullany, Panettieri, 
      Subramanian and Das.
FAU - Hashem, Tanwir
AU  - Hashem T
AD  - Department of Physiology, College of Natural Science, Michigan State University, 
      East Lansing, MI, United States.
FAU - Kammala, Ananth K
AU  - Kammala AK
AD  - College of Human Medicine, Michigan State University, East Lansing, MI, United 
      States.
FAU - Thaxton, Kanedra
AU  - Thaxton K
AD  - Department of Physiology, College of Natural Science, Michigan State University, 
      East Lansing, MI, United States.
FAU - Griffin, Ryan M
AU  - Griffin RM
AD  - Department of Physiology, College of Natural Science, Michigan State University, 
      East Lansing, MI, United States.
FAU - Mullany, Kellie
AU  - Mullany K
AD  - Department of Chemical Engineering and Material Science, College of Engineering, 
      Michigan State University, East Lansing, MI, United States.
FAU - Panettieri, Reynold A Jr
AU  - Panettieri RA Jr
AD  - Rutgers Institute for Translational Medicine and Science, New Brunswick, NJ, 
      United States.
FAU - Subramanian, Hariharan
AU  - Subramanian H
AD  - College of Human Medicine, Michigan State University, East Lansing, MI, United 
      States.
FAU - Das, Rupali
AU  - Das R
AD  - College of Human Medicine, Michigan State University, East Lansing, MI, United 
      States.
LA  - eng
GR  - K22 CA188149/CA/NCI NIH HHS/United States
GR  - P01 HL114471/HL/NHLBI NIH HHS/United States
GR  - R25 HL108864/HL/NHLBI NIH HHS/United States
GR  - UL1 TR003017/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200512
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (CD2 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-13)
SB  - IM
MH  - Animals
MH  - Asthma/*genetics/*physiopathology
MH  - Bronchoalveolar Lavage Fluid
MH  - CD2 Antigens/*genetics
MH  - Cytokines/analysis/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation
MH  - Inflammation/etiology
MH  - Interleukin-13/analysis
MH  - Lung/drug effects/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Pyroglyphidae/*chemistry/*immunology
MH  - Respiratory Hypersensitivity/etiology
MH  - Th2 Cells/immunology
PMC - PMC7235426
OTO - NOTNLM
OT  - CD2
OT  - Th2-allergic response
OT  - asthma
OT  - costimulatory molecules
OT  - house dust mite extract
OT  - interleukin (IL)-13
OT  - microRNAs
EDAT- 2020/06/02 06:00
MHDA- 2021/04/07 06:00
PMCR- 2020/01/01
CRDT- 2020/06/02 06:00
PHST- 2020/02/25 00:00 [received]
PHST- 2020/04/16 00:00 [accepted]
PHST- 2020/06/02 06:00 [entrez]
PHST- 2020/06/02 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.00881 [doi]
PST - epublish
SO  - Front Immunol. 2020 May 12;11:881. doi: 10.3389/fimmu.2020.00881. eCollection 
      2020.