PMID- 32477689
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201210
IS  - 2153-4063 (Print)
IS  - 2153-4063 (Electronic)
VI  - 2020
DP  - 2020
TI  - A Population-Based Study of Simvastatin Drug-Drug Interactions in Cardiovascular 
      Disease Patients.
PG  - 664-673
AB  - Simvastatin is a commonly used medication for lipid management and cardiovascular 
      disease, however, the risk of adverse events (AEs) with its use increases via 
      drug-drug interaction (DDI) exposures. Patients were extracted if initially 
      diagnosed with cardiovascular disease and newly initiated simvastatin therapy. 
      The cohort was divided into a DDI-exposed group and a non-DDI exposed group. The 
      DDI-exposed group was further divided into gemfibrozil, clarithromycin, and 
      erythromycin exposure groups. The outcome was defined as a composite of 
      predefined AEs. Our results show that the simvastatin-DDI group had a higher 
      illness burden with longer simvastatin exposure time and more medical care 
      follow-up compared with the simvastatin-non-DDI exposed group. AEs occurred more 
      frequently in subjects exposed to interacting drugs with a higher risk for 
      clarithromycin and erythromycin exposed subjects than for gemfibrozil subjects.
CI  - (c)2020 AMIA - All rights reserved.
FAU - Wang, Jin
AU  - Wang J
AD  - Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
AD  - OptumLabs Visiting Fellow, Cambridge, MA, USA.
FAU - Chi, Chih-Lin
AU  - Chi CL
AD  - Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
AD  - School of Nursing, University of Minnesota, Minneapolis, MN, USA.
AD  - OptumLabs Visiting Fellow, Cambridge, MA, USA.
FAU - St Peter, Wendy L
AU  - St Peter WL
AD  - College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
FAU - Carlson, Angie
AU  - Carlson A
AD  - College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
FAU - Loth, Matt
AU  - Loth M
AD  - Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
AD  - School of Nursing, University of Minnesota, Minneapolis, MN, USA.
AD  - OptumLabs Visiting Fellow, Cambridge, MA, USA.
FAU - Pradhan, Prajwal Mani
AU  - Pradhan PM
AD  - Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
AD  - OptumLabs Visiting Fellow, Cambridge, MA, USA.
FAU - Liang, Yue
AU  - Liang Y
AD  - Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
AD  - OptumLabs Visiting Fellow, Cambridge, MA, USA.
FAU - Chen, Wei-Yu
AU  - Chen WY
AD  - Department of Computer Science & Engineering, University of Minnesota, 
      Minneapolis, MN, USA.
AD  - OptumLabs Visiting Fellow, Cambridge, MA, USA.
FAU - Lenskaia, Tatiana
AU  - Lenskaia T
AD  - Bioinformatics and Computational Biology program, University of Minnesota, 
      Minneapolis, MN, USA.
AD  - OptumLabs Visiting Fellow, Cambridge, MA, USA.
FAU - Robinson, Jennifer G
AU  - Robinson JG
AD  - Departments of Epidemiology & Medicine, University of Iowa, IA, USA.
FAU - Adam, Terrence J
AU  - Adam TJ
AD  - Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
AD  - College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
LA  - eng
GR  - R01 HL143390/HL/NHLBI NIH HHS/United States
GR  - UL1 TR002494/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20200530
PL  - United States
TA  - AMIA Jt Summits Transl Sci Proc
JT  - AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on 
      Translational Science
JID - 101539486
PMC - PMC7233072
EDAT- 2020/06/02 06:00
MHDA- 2020/06/02 06:01
PMCR- 2020/05/30
CRDT- 2020/06/02 06:00
PHST- 2020/06/02 06:00 [entrez]
PHST- 2020/06/02 06:00 [pubmed]
PHST- 2020/06/02 06:01 [medline]
PHST- 2020/05/30 00:00 [pmc-release]
AID - 3269620 [pii]
PST - epublish
SO  - AMIA Jt Summits Transl Sci Proc. 2020 May 30;2020:664-673. eCollection 2020.