PMID- 32478570
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 61
IP  - 12
DP  - 2021
TI  - Bioactive peptides from beans with the potential to decrease the risk of 
      developing noncommunicable chronic diseases.
PG  - 2003-2021
LID - 10.1080/10408398.2020.1768047 [doi]
AB  - Several studies have demonstrated that peptides obtained from the proteins of 
      different bean species have the potential to act on therapeutic targets of 
      noncommunicable chronic diseases or NCDs. However, peptides with great structural 
      diversity can be obtained from the hydrolysis of proteins present in foods. 
      Therefore, the present review had the objective of identifying, in silico, the 
      possibility of obtaining peptides with potential biological activity from the 
      storage globulin proteins of the bean species Phaseolus vulgaris (L.), Vigna 
      angularis (Willd.), Vigna radiata (L.) and Vigna unguiculata (L.) Walp., using 
      the UniProtKB, BIOPEP and PeptideRanker databases, as well as reviewing available 
      research reports that showed evidence bioactive properties of peptides obtained 
      from beans via in vitro assays. For all the species studied, the highest 
      frequency of the occurrence of bioactive fragments was found for the inhibition 
      of dipeptidyl peptidase-IV, followed by the inhibition of the 
      angiotensin-converting enzyme and by antioxidant activity. The inhibition of the 
      two enzymes is the therapeutic target of drugs used for type 2 diabetes mellitus 
      (T2DM) and for hypertension, respectively, while the antioxidant activity can 
      prevent the development of several chronic diseases related to oxidative stress.
FAU - de Fatima Garcia, Bianca
AU  - de Fatima Garcia B
AD  - Department of Food Science and Technology, State University of Londrina - UEL, 
      Londrina, PR, Brazil.
FAU - de Barros, Marcio
AU  - de Barros M
AUID- ORCID: 0000-0001-7569-9926
AD  - Department of Food Science and Technology, State University of Londrina - UEL, 
      Londrina, PR, Brazil.
FAU - de Souza Rocha, Thais
AU  - de Souza Rocha T
AUID- ORCID: 0000-0003-1639-5484
AD  - Department of Food Science and Technology, State University of Londrina - UEL, 
      Londrina, PR, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200601
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Dipeptidyl-Peptidase IV Inhibitors)
RN  - 0 (Peptides)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors
MH  - Chronic Disease
MH  - *Diabetes Mellitus, Type 2/prevention & control
MH  - *Dipeptidyl-Peptidase IV Inhibitors
MH  - Humans
MH  - Peptides
OTO - NOTNLM
OT  - Arterial hypertension
OT  - bioinformatics
OT  - protein
OT  - public health
OT  - type 2 diabetes mellitus
EDAT- 2020/06/02 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/06/02 06:00
PHST- 2020/06/02 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/06/02 06:00 [entrez]
AID - 10.1080/10408398.2020.1768047 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2021;61(12):2003-2021. doi: 
      10.1080/10408398.2020.1768047. Epub 2020 Jun 1.