PMID- 32479003
OWN - NLM
STAT- MEDLINE
DCOM- 20201218
LR  - 20201218
IS  - 1940-4344 (Electronic)
IS  - 1940-4344 (Linking)
VI  - 22
IP  - 2
DP  - 2020
TI  - Effect of the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii 
      (Agaricomycetes) Basidiocarps Powder to Ameliorate Memory and Learning Deficit in 
      Ability in Abeta-Induced Alzheimer's Disease C57BL/6J Mice Model.
PG  - 145-159
LID - 10.1615/IntJMedMushrooms.2020033766 [doi]
AB  - One of the major causes of Alzheimer's disease (AD) is oxidative stress, which 
      accelerates beta-amyloid peptide (AP) plaque and neurofibrillary tangle accumulation 
      in the brain. Pleurotus eryngii is known to be rich in antioxidants, including 
      ergothioneine, adenosine, and polyphenol, which can reduce oxidative 
      stress-related aging. The aim of this study was to investigate the proximate and 
      functional composition of P. eryngii, and evaluate the cognitive effects of low 
      (LPE), medium (MPE), and high (HPE) P. eryngii dosages in an Abeta-induced 
      Alzheimer's disease C57BL/6J mouse model. Mice fed P. eryngii for six weeks 
      showed no adverse effects on body weight gain, food intake efficiency, serum 
      biochemical parameters, and liver and kidney histopathological features. The 
      relative brain weight was significantly lower in Abeta-injected mice (p < 0.05). 
      Further, P. eryngii was shown to delay brain atrophy. Reference memory behavioral 
      tasks showed that LPE, MPE, and HPE significantly decreased escape latency 
      (49-85%) and distance (53-69%, p < 0.05). Probe and T-maze tasks showed that P. 
      eryngii potently ameliorated memory deficit in mice. An AD pathology index 
      analysis showed that P. eryngii significantly decreased levels of brain 
      phosphorylated tau-protein, Abeta plaque deposition, malondialdehyde, and protein 
      carbonyl (p < 0.05). P. eryngii may therefore promote memory and learning 
      capacity in an Abeta-induced AD mouse model.
FAU - Liang, Chih-Hung
AU  - Liang CH
AD  - Department of Nutrition and Health Science, Chungchou Institute of Technology, 
      Yuanlin, Changhua 51003, Taiwan, ROC; Department of Food Science, Tunghai 
      University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, 
      Taichung, Taiwan.
FAU - Huang, Po-Chang
AU  - Huang PC
AD  - Department of Food Science and Biotechnology, National Chung Hsing University, 
      No. 145 Hsing-Da Road, Taichung 40227, Taiwan.
FAU - Mau, Jeng-Leun
AU  - Mau JL
AD  - Department of Food Science and Biotechnology, National Chung Hsing University, 
      No. 145 Hsing-Da Road, Taichung 40227, Taiwan.
FAU - Chiang, Shen-Shih
AU  - Chiang SS
AD  - Department of Food Science and Biotechnology, National Chung Hsing University, 
      No. 145 Hsing-Da Road, Taichung 40227, Taiwan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Med Mushrooms
JT  - International journal of medicinal mushrooms
JID - 100886202
RN  - 0 (APP protein, mouse)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Antioxidants)
RN  - 0 (Powders)
SB  - IM
MH  - Alzheimer Disease/chemically induced/*drug therapy/pathology
MH  - Amyloid beta-Peptides/*metabolism
MH  - Amyloid beta-Protein Precursor/adverse effects/metabolism
MH  - Animals
MH  - Antioxidants/chemistry/*pharmacology
MH  - Brain/drug effects/pathology
MH  - Disease Models, Animal
MH  - Fruiting Bodies, Fungal/*chemistry
MH  - Humans
MH  - Learning Disabilities/*drug therapy/pathology
MH  - Memory Disorders/*drug therapy/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oxidative Stress
MH  - Pleurotus/*chemistry
MH  - Powders/chemistry/pharmacology
EDAT- 2020/06/02 06:00
MHDA- 2020/12/19 06:00
CRDT- 2020/06/02 06:00
PHST- 2020/06/02 06:00 [entrez]
PHST- 2020/06/02 06:00 [pubmed]
PHST- 2020/12/19 06:00 [medline]
AID - 2c85f08c5b707d7a,436bc4b158293b05 [pii]
AID - 10.1615/IntJMedMushrooms.2020033766 [doi]
PST - ppublish
SO  - Int J Med Mushrooms. 2020;22(2):145-159. doi: 
      10.1615/IntJMedMushrooms.2020033766.