PMID- 32479691
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231129
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 80
IP  - 5
DP  - 2020 Aug
TI  - Inducible nitric oxide synthase inhibitor, aminoguanidine improved Ki67 as a 
      marker of neurogenesis and learning and memory in juvenile hypothyroid rats.
PG  - 429-442
LID - 10.1002/jdn.10042 [doi]
AB  - INTRODUCTION: In the present study, the effect of inducible nitric oxide (NO) 
      synthase inhibitor, aminoguanidine (AG) on neurogenesis indicators, learning and 
      memory, and oxidative stress status in juvenile hypothyroid (Hypo) rats was 
      evaluated. METHOD: The studied groups were including: (a) Control, (b) Hypo, 
      (c-e) Hypo-AG 10, Hypo-AG 20, and Hypo-AG 30. Hypothyroidism was induced in the 
      groups 2-5 by adding propylthiouracil in drinking water (0.05%). AG (10, 20, or 
      30 mg/kg) was daily injected intraperitoneally in the groups 3-5. The rats of the 
      groups 1 and 2 were injected by saline instead of AG. After 6 weeks treatment, 
      Morris water maze (MMW) and passive avoidance (PA) tests were done. Deep 
      anesthesia was then induced and the brain tissue was excised for biochemical 
      parameters measuring. RESULTS: Ki67 as a maker of neurogenesis and thiol, 
      superoxide dismutase (SOD), and catalase (CAT) as oxidative stress indicators 
      were decreased in the brain of Hypo group, whereas malondialdehyde (MDA) and NO 
      metabolites were enhanced. AG improved Ki67, thiol, CAT, and SOD while decreased 
      MDA and NO metabolites. The escape latency in the MWM test increased in the Hypo 
      group. The spending time in the target quadrant in the probe test of MWM and 
      step-through latency in the PA test in the Hypo group was lower than Control 
      group. AG reversed all the negative behavioral effects of hypothyroidism. 
      CONCLUSION: These results revealed that AG improved neurogenesis, learning and 
      memory impairments, and oxidative imbalance in the brain juvenile Hypo rats.
CI  - (c) 2020 International Society for Developmental Neuroscience.
FAU - Alikhani, Vajiheh
AU  - Alikhani V
AD  - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research 
      Center, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Beheshti, Farimah
AU  - Beheshti F
AUID- ORCID: 0000-0003-1524-2339
AD  - Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, 
      Torbat Heydariyeh, Iran.
AD  - Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh 
      University of Medical Sciences, Torbat Heydariyeh, Iran.
FAU - Ghasemzadeh Rahbardar, Mahboobeh
AU  - Ghasemzadeh Rahbardar M
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Marefati, Narges
AU  - Marefati N
AD  - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research 
      Center, Mashhad University of Medical Sciences, Mashhad, Iran.
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Mansouritorghabeh, Fatemeh
AU  - Mansouritorghabeh F
AD  - Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Hosseini, Mahmoud
AU  - Hosseini M
AUID- ORCID: 0000-0001-6425-5123
AD  - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research 
      Center, Mashhad University of Medical Sciences, Mashhad, Iran.
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
LA  - eng
GR  - 960265/Mashhad University of Medical Sciences/
PT  - Journal Article
DEP - 20200620
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
SB  - IM
OTO - NOTNLM
OT  - aminoguanidine
OT  - hypothyroidism
OT  - ki67
OT  - learning
OT  - memory
OT  - nitric oxide
EDAT- 2020/06/02 06:00
MHDA- 2020/06/02 06:01
CRDT- 2020/06/02 06:00
PHST- 2020/05/12 00:00 [revised]
PHST- 2020/04/15 00:00 [received]
PHST- 2020/05/25 00:00 [accepted]
PHST- 2020/06/02 06:01 [medline]
PHST- 2020/06/02 06:00 [pubmed]
PHST- 2020/06/02 06:00 [entrez]
AID - 10.1002/jdn.10042 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2020 Aug;80(5):429-442. doi: 10.1002/jdn.10042. Epub 2020 Jun 
      20.