PMID- 32480134
OWN - NLM
STAT- MEDLINE
DCOM- 20201118
LR  - 20201118
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 41
IP  - 4
DP  - 2020 Jul-Aug
TI  - Clinical significance of neuropilin-2 expression in laryngeal squamous cell 
      carcinoma.
PG  - 102540
LID - S0196-0709(20)30231-3 [pii]
LID - 10.1016/j.amjoto.2020.102540 [doi]
AB  - PURPOSE: The purpose of the study is to evaluate the expression of NRP-2 and 
      explore its role in Laryngeal squamous cell carcinoma (LSCC). MATERIALS AND 
      METHODS: NRP-2 expression in 70 primary LSCC tissue specimens were analyzed by 
      immunohistochemistry and correlated with clinicopathological parameters and 
      patients  survival rate. Additionally, 9 paired LSCC tissues were evaluated for 
      NRP-2 expression by Western blotting. RESULTS: The Western blotting indicated 
      that NRP-2 expression levels in LSCC were significantly higher than those in the 
      paraneoplastic tissues (P < 0.05). Immunohistochemistry staining revealed that 
      NRP-2 was detected in all primary tumor samples, moreover, high expression of 
      NRP-2 was significantly correlated with TNM stage (P < 0.05), clinical stage 
      (P < 0.05), histological classification (P < 0.05), lymph node metastasis 
      (P < 0.05) and recurrence (P = 0.001). Survival curves determined by the 
      Kaplan-Meier method showed that high expression of NRP-2 can reduce overall 
      survival (both group P < 0.05). Then we combined the NRP-2 expression and lymph 
      node status, and Kaplan-Meier survival showed patients with high expression of 
      NRP-2 or lymph node metastasis (+) had both shorter disease-free and overall 
      survival than others (both P < 0.05). Multivariate Cox proportional hazards model 
      analysis confirmed that histological grade (P = 0.045), lymph node metastasis 
      (P = 0.020) and high expression of NRP-2 (P = 0.033) were statistically 
      significant, independent predictor of prognosis. CONCLUSIONS: NRP-2 may 
      contribute to LSCC progression and represents as a novel prognostic indicator as 
      well as a potential therapeutic target for LSCC.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Yin, Danhui
AU  - Yin D
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Guo, Lu
AU  - Guo L
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Li, Shisheng
AU  - Li S
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China. 
      Electronic address: lissdoctor@csu.edu.cn.
FAU - Tuerdi, Ayinuer
AU  - Tuerdi A
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China. 
      Electronic address: 22018095@csu.edu.cn.
FAU - Yang, Xinming
AU  - Yang X
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Tang, Qinglai
AU  - Tang Q
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Wang, Shuang
AU  - Wang S
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Liu, Jiajia
AU  - Liu J
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Huang, Peiying
AU  - Huang P
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Li, Mengmeng
AU  - Li M
AD  - Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200507
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Neuropilin-2)
RN  - 0 (neuropilin-2, human)
SB  - IM
MH  - Disease Progression
MH  - Female
MH  - *Gene Expression
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/mortality/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neuropilin-2/*genetics/*metabolism
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Squamous Cell Carcinoma of Head and Neck/*genetics/mortality/pathology
MH  - Survival Rate
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - Metastasis
OT  - NRP-2
OT  - Prognosis
EDAT- 2020/06/02 06:00
MHDA- 2020/11/20 06:00
CRDT- 2020/06/02 06:00
PHST- 2020/03/05 00:00 [received]
PHST- 2020/04/21 00:00 [revised]
PHST- 2020/05/03 00:00 [accepted]
PHST- 2020/06/02 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2020/06/02 06:00 [entrez]
AID - S0196-0709(20)30231-3 [pii]
AID - 10.1016/j.amjoto.2020.102540 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2020 Jul-Aug;41(4):102540. doi: 10.1016/j.amjoto.2020.102540. 
      Epub 2020 May 7.