PMID- 32481844
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200602
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 2
IP  - 5
DP  - 2014 May 1
TI  - Fabrication of zeolite-polymer composite nanofibers for removal of uremic toxins 
      from kidney failure patients.
PG  - 674-679
LID - 10.1039/c3bm60263j [doi]
AB  - There is a need to develop a simple, cheap, and accessible method of treating 
      patients with kidney failure, especially in resource-limited environments such as 
      disaster areas and the developing world due to the inaccessibility of 
      conventional hemodialysis treatments. In this study, we develop a zeolite-polymer 
      composite nanofiber mesh to remove uremic toxins for blood purification. The 
      nanofiber is composed of blood compatible poly(ethylene-co-vinyl alcohol) (EVOH) 
      as the primary matrix polymer and zeolites which are capable of selectively 
      adsorbing uremic toxins such as creatinine. The composite fiber meshes were 
      produced by a cost-effective electrospinning method: electrospinning composite 
      solutions of EVOH and zeolites. Scanning electron microscope (SEM) images 
      revealed that the 7 w/v% EVOH solution produced non-woven fibers with a 
      continuous and smooth morphology. The SEM also showed that over 90% of zeolites 
      in the solution were successfully incorporated into the EVOH nanofibers. Although 
      the barrier properties of the EVOH matrix lowered the creatinine adsorption 
      capacity of the zeolites in the fiber when compared with adsorption to free 
      zeolites, their adsorption capacity was still 67% of the free zeolites. The 
      proposed composite fibers have the potential to be utilized as a new approach to 
      removing nitrogenous waste products from the bloodstream without the requirement 
      of specialized equipment.
FAU - Namekawa, Koki
AU  - Namekawa K
AD  - Biomaterials Unit, International Center for Materials Nanoarchitectonics 
      (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, 
      Ibaraki 305-0044, Japan. EBARA.Mitsuhiro@nims.go.jp.
FAU - Tokoro Schreiber, Makoto
AU  - Tokoro Schreiber M
FAU - Aoyagi, Takao
AU  - Aoyagi T
FAU - Ebara, Mitsuhiro
AU  - Ebara M
LA  - eng
PT  - Journal Article
DEP - 20140131
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
SB  - IM
EDAT- 2014/05/01 00:00
MHDA- 2014/05/01 00:01
CRDT- 2020/06/03 06:00
PHST- 2020/06/03 06:00 [entrez]
PHST- 2014/05/01 00:00 [pubmed]
PHST- 2014/05/01 00:01 [medline]
AID - 10.1039/c3bm60263j [doi]
PST - ppublish
SO  - Biomater Sci. 2014 May 1;2(5):674-679. doi: 10.1039/c3bm60263j. Epub 2014 Jan 31.