PMID- 32483245
OWN - NLM
STAT- MEDLINE
DCOM- 20201126
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jun 1
TI  - Moringa Isothiocyanate-rich Seed Extract Delays the Onset of Diabetes in UC Davis 
      Type-2 Diabetes Mellitus Rats.
PG  - 8861
LID - 10.1038/s41598-020-65722-6 [doi]
LID - 8861
AB  - Moringa seeds have been used traditionally in the management of type 2 diabetes 
      mellitus (T2DM) and contain potent bioactive isothiocyanates. This study 
      evaluated the efficacy of an isothiocyanate-rich moringa seed extract in delaying 
      the onset of T2DM in UC Davis T2DM rats, a well validated model which closely 
      mimics T2DM in humans. Rats were separated into three groups; control, moringa 
      seed extract at 0.4%, and a weight matched group. Rats were fed respective diets 
      for 8 months, during which energy intake, body weight, the onset of diabetes 
      circulating hormones, metabolites and markers of inflammation and liver function, 
      and were monitored. The MS group had a significantly slower rate of diabetes 
      onset p = 0.027), lower plasma glucose (p = 0.043), and lower HbA1c (p = 0.008) 
      compared with CON animals. There were no significant differences in food intake 
      and body weight between all groups. This study demonstrated MS can delay the 
      onset of diabetes in the UC Davis T2DM rat model to a greater extent than 
      moderate caloric restriction (by comparison to the WM group). The results support 
      its documented traditional uses and a bioactive role of moringa isothiocyanates 
      and suggest the potential efficacy for moringa supplementation for diabetes 
      management in populations at risk for T2DM.
FAU - Waterman, Carrie
AU  - Waterman C
AD  - Department of Nutrition, UC Davis, One Shields Ave, Davis, CA, 95616, USA. 
      cwaterman@ucdavis.edu.
FAU - Graham, James L
AU  - Graham JL
AD  - Department of Nutrition, UC Davis, One Shields Ave, Davis, CA, 95616, USA.
AD  - Department of Molecular Biosciences, School of Veterinary Medicine, UC, Davis, 
      USA.
FAU - Arnold, Charles D
AU  - Arnold CD
AD  - Department of Nutrition, UC Davis, One Shields Ave, Davis, CA, 95616, USA.
FAU - Stanhope, Kimber L
AU  - Stanhope KL
AD  - Department of Nutrition, UC Davis, One Shields Ave, Davis, CA, 95616, USA.
FAU - Tong, Jason H
AU  - Tong JH
AD  - Department of Nutrition, UC Davis, One Shields Ave, Davis, CA, 95616, USA.
FAU - Jaja-Chimedza, Asha
AU  - Jaja-Chimedza A
AD  - Department of Plant Biology, Rutgers University, 59 Dudley Rd, New Brunswick, NJ, 
      08901, USA.
FAU - Havel, Peter J
AU  - Havel PJ
AD  - Department of Nutrition, UC Davis, One Shields Ave, Davis, CA, 95616, USA.
AD  - Department of Molecular Biosciences, School of Veterinary Medicine, UC, Davis, 
      USA.
LA  - eng
GR  - 009987/U.S. Department of Health & Human Services | NIH | Fogarty 
      International Center (FIC)/International
PT  - Journal Article
DEP - 20200601
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Isothiocyanates)
RN  - 0 (Plant Extracts)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Weight/drug effects
MH  - Diabetes Mellitus, Type 2/pathology/*prevention & control
MH  - Disease Models, Animal
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Isothiocyanates/chemistry/pharmacology/*therapeutic use
MH  - Male
MH  - Moringa/*chemistry/metabolism
MH  - Plant Extracts/*chemistry/pharmacology/therapeutic use
MH  - Rats
MH  - Seeds/chemistry/metabolism
MH  - Triglycerides/blood
PMC - PMC7264139
COIS- C.W. is a co-inventor on the US patent application No. 14683730 titled: Extracts 
      from Plants of the Moringaceae Family and Methods of Making. This does not alter 
      our adherence to Journal of Nutrition policies on sharing data and materials. All 
      other authors declare no conflict of interest.
EDAT- 2020/06/03 06:00
MHDA- 2020/11/27 06:00
PMCR- 2020/06/01
CRDT- 2020/06/03 06:00
PHST- 2019/06/05 00:00 [received]
PHST- 2020/05/07 00:00 [accepted]
PHST- 2020/06/03 06:00 [entrez]
PHST- 2020/06/03 06:00 [pubmed]
PHST- 2020/11/27 06:00 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - 10.1038/s41598-020-65722-6 [pii]
AID - 65722 [pii]
AID - 10.1038/s41598-020-65722-6 [doi]
PST - epublish
SO  - Sci Rep. 2020 Jun 1;10(1):8861. doi: 10.1038/s41598-020-65722-6.