PMID- 32484215
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 30
IP  - 10
DP  - 2020 Sep 3
TI  - Corticostriatal White Matter Integrity and Dopamine D1 Receptor Availability 
      Predict Age Differences in Prefrontal Value Signaling during Reward Learning.
PG  - 5270-5280
LID - 10.1093/cercor/bhaa104 [doi]
AB  - Probabilistic reward learning reflects the ability to adapt choices based on 
      probabilistic feedback. The dopaminergically innervated corticostriatal circuit 
      in the brain plays an important role in supporting successful probabilistic 
      reward learning. Several components of the corticostriatal circuit deteriorate 
      with age, as it does probabilistic reward learning. We showed previously that D1 
      receptor availability in NAcc predicts the strength of anticipatory value 
      signaling in vmPFC, a neural correlate of probabilistic learning that is 
      attenuated in older participants and predicts probabilistic reward learning 
      performance. We investigated how white matter integrity in the pathway between 
      nucleus accumbens (NAcc) and ventromedial prefrontal cortex (vmPFC) relates to 
      the strength of anticipatory value signaling in vmPFC in younger and older 
      participants. We found that in a sample of 22 old and 23 young participants, 
      fractional anisotropy in the pathway between NAcc and vmPFC predicted the 
      strength of value signaling in vmPFC independently from D1 receptor availability 
      in NAcc. These findings provide tentative evidence that integrity in the 
      dopaminergic and white matter pathways of corticostriatal circuitry supports the 
      expression of value signaling in vmPFC which supports reward learning, however, 
      the limited sample size calls for independent replication. These and future 
      findings could add to the improved understanding of how corticostriatal integrity 
      contributes to reward learning ability.
CI  - (c) The Author(s) 2020. Published by Oxford University Press.
FAU - de Boer, Lieke
AU  - de Boer L
AD  - Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska 
      Institutet, Stockholm 171 65, Sweden.
FAU - Garzon, Benjamin
AU  - Garzon B
AD  - Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska 
      Institutet, Stockholm 171 65, Sweden.
FAU - Axelsson, Jan
AU  - Axelsson J
AD  - Department of Radiation Sciences, Diagnostic Radiology, University Hospital, Umea 
      University, Umea SE-901 87, Sweden.
AD  - Department of Integrative Medical Biology, Physiology, Umea University, Umea 
      SE-901 87, Sweden.
FAU - Riklund, Katrine
AU  - Riklund K
AD  - Department of Radiation Sciences, Diagnostic Radiology, University Hospital, Umea 
      University, Umea SE-901 87, Sweden.
AD  - Department of Integrative Medical Biology, Physiology, Umea University, Umea 
      SE-901 87, Sweden.
FAU - Nyberg, Lars
AU  - Nyberg L
AD  - Department of Radiation Sciences, Diagnostic Radiology, University Hospital, Umea 
      University, Umea SE-901 87, Sweden.
AD  - Department of Integrative Medical Biology, Physiology, Umea University, Umea 
      SE-901 87, Sweden.
AD  - Umea Center for Functional Brain Imaging, Umea University, Umea 907 36, Sweden.
FAU - Backman, Lars
AU  - Backman L
AD  - Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska 
      Institutet, Stockholm 171 65, Sweden.
FAU - Guitart-Masip, Marc
AU  - Guitart-Masip M
AD  - Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska 
      Institutet, Stockholm 171 65, Sweden.
AD  - Max Planck UCL Centre for Computational Psychiatry and Ageing Research, 
      University College London, London WC1B 5EH, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Receptors, Dopamine D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Brain Mapping
MH  - Diffusion Magnetic Resonance Imaging
MH  - Humans
MH  - Learning/*physiology
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/anatomy & histology/physiology
MH  - Nucleus Accumbens/anatomy & histology/*physiology
MH  - Positron-Emission Tomography
MH  - Prefrontal Cortex/anatomy & histology/*physiology
MH  - Receptors, Dopamine D1/*metabolism
MH  - *Reward
MH  - White Matter/anatomy & histology/*physiology
MH  - Young Adult
PMC - PMC7472214
OTO - NOTNLM
OT  - aging
OT  - corticostriatal loops
OT  - dopamine
OT  - value-based decision making
OT  - white matter integrity
EDAT- 2020/06/03 06:00
MHDA- 2021/12/21 06:00
PMCR- 2020/06/02
CRDT- 2020/06/03 06:00
PHST- 2019/11/13 00:00 [received]
PHST- 2020/03/18 00:00 [revised]
PHST- 2020/03/18 00:00 [accepted]
PHST- 2020/06/03 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2020/06/03 06:00 [entrez]
PHST- 2020/06/02 00:00 [pmc-release]
AID - 5850052 [pii]
AID - bhaa104 [pii]
AID - 10.1093/cercor/bhaa104 [doi]
PST - ppublish
SO  - Cereb Cortex. 2020 Sep 3;30(10):5270-5280. doi: 10.1093/cercor/bhaa104.