PMID- 32484226
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20210106
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Print)
IS  - 1672-9145 (Linking)
VI  - 52
IP  - 6
DP  - 2020 Jun 20
TI  - Role and effect of vein-transplanted human umbilical cord mesenchymal stem cells 
      in the repair of diabetic foot ulcers in rats.
PG  - 620-630
LID - 10.1093/abbs/gmaa039 [doi]
AB  - Diabetic foot ulcer (DFU) is one of diabetic complications, which is frequently 
      present and tormented in diabetes mellitus. Most multipotent mesenchymal stromal 
      cells (MSCs) are capable of immune evasion, providing an allogeneic, 
      ready-to-use, cell product option for therapeutic applications. The beneficial 
      effect of MSCs for the treatment of a variety of traumatic injuries, such as open 
      wounds, has been extensively explored. In this study, a rat DFU model was used to 
      simulate the pathophysiology of clinical patients and to investigate the 
      localization of human umbilical cord mesenchymal stem cells (hUC-MSCs) after 
      intravenous transplantation and its role in DFU healing, so as to evaluate the 
      potential of hUC-MSCs in the treatment of DFU. The diabetic rat model was 
      established by streptozotocin injection, which was used to create full-thickness 
      foot dorsal skin wounds to mimic DFU by a 6-mm skin biopsy punch and a Westcott 
      scissor. The hUC-MSCs were transplanted through femoral vein, and the ulcer 
      cicatrization situation and the fate of hUC-MSCs were evaluated. Our data suggest 
      that intravenously transplantated hUC-MSCs have the ability to migrate and locate 
      to the wound tissue and are helpful to wound healing in DFU rats, partly by 
      regulating inflammation, trans-differentiation and providing growth factors that 
      promote angiogenesis, cell proliferation and collagen deposition. Herein, we 
      demonstrate that hUC-MSC transplantation is able to accelerate DFU healing in 
      rats and transplantation of exogenous stem cells may be a potential strategy for 
      clinical application in DFUs.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological 
      Sciences, Chinese Academy of Sciences.
FAU - Shi, Rongfeng
AU  - Shi R
AD  - Department of Interventional Radiology, Affiliated Hospital of Nantong 
      University, Nantong 226001, China.
FAU - Lian, Weishuai
AU  - Lian W
AD  - Department of Interventional & Vascular Surgery, Shanghai Tenth People's 
      Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
AD  - Institute of Medical Intervention Engineering, Tongji University, Shanghai 
      200072, China.
FAU - Jin, Yinpeng
AU  - Jin Y
AD  - Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
FAU - Cao, Chuanwu
AU  - Cao C
AD  - Department of Interventional & Vascular Surgery, Shanghai Tenth People's 
      Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
AD  - Institute of Medical Intervention Engineering, Tongji University, Shanghai 
      200072, China.
FAU - Han, Shilong
AU  - Han S
AD  - Department of Interventional & Vascular Surgery, Shanghai Tenth People's 
      Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
AD  - Institute of Medical Intervention Engineering, Tongji University, Shanghai 
      200072, China.
FAU - Yang, Xiaohu
AU  - Yang X
AD  - Department of Interventional Radiology, Affiliated Hospital of Nantong 
      University, Nantong 226001, China.
FAU - Zhao, Suming
AU  - Zhao S
AD  - Department of Interventional Radiology, Affiliated Hospital of Nantong 
      University, Nantong 226001, China.
FAU - Li, Maoquan
AU  - Li M
AD  - Department of Interventional & Vascular Surgery, Shanghai Tenth People's 
      Hospital, Tongji University, School of Medicine, Shanghai 200072, China.
AD  - Institute of Medical Intervention Engineering, Tongji University, Shanghai 
      200072, China.
FAU - Zhao, Hui
AU  - Zhao H
AD  - Department of Interventional Radiology, Affiliated Hospital of Nantong 
      University, Nantong 226001, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/metabolism/pathology/therapy
MH  - *Diabetic Foot/metabolism/pathology/therapy
MH  - Female
MH  - Heterografts
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Umbilical Veins/*metabolism/pathology
PMC - PMC7333920
OTO - NOTNLM
OT  - diabetic foot ulcer
OT  - human umbilical cord mesenchymal stem cells
OT  - tissue repair
EDAT- 2020/06/03 06:00
MHDA- 2021/01/07 06:00
PMCR- 2020/06/02
CRDT- 2020/06/03 06:00
PHST- 2019/11/04 00:00 [received]
PHST- 2020/01/15 00:00 [revised]
PHST- 2020/03/31 00:00 [accepted]
PHST- 2020/06/03 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2020/06/03 06:00 [entrez]
PHST- 2020/06/02 00:00 [pmc-release]
AID - 5850130 [pii]
AID - gmaa039 [pii]
AID - 10.1093/abbs/gmaa039 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2020 Jun 20;52(6):620-630. doi: 
      10.1093/abbs/gmaa039.