PMID- 32484314
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 2328-9503 (Electronic)
IS  - 2328-9503 (Linking)
VI  - 7
IP  - 6
DP  - 2020 Jun
TI  - Fc-gamma IIIa-V158F receptor polymorphism contributes to the severity of 
      Guillain-Barre syndrome.
PG  - 1040-1049
LID - 10.1002/acn3.51072 [doi]
AB  - OBJECTIVE: Guillain-Barre syndrome (GBS) is a rare, life-threatening disorder of 
      the peripheral nervous system. Immunoglobulin G Fc-gamma receptors (FcgammaRs) 
      mediate and regulate diverse effector functions and are involved in the 
      pathogenesis of GBS. We investigated whether the FcgammaR polymorphisms FcgammaRIIa 
      H/R131 (rs1801274), FcgammaRIIIa V/F158 (rs396991), and FcgammaRIIIb NA1/NA2, and their 
      haplotype patterns affect the affinity of IgG-FcgammaR interactivity and influence 
      GBS susceptibility and severity. METHODS: We determined FcgammaR polymorphisms in 303 
      patients with GBS and 302 ethnically matched healthy individuals from Bangladesh 
      by allele-specific polymerase chain reaction. Pairwise linkage disequilibrium and 
      haplotype patterns were analyzed based on D ́statistics and the genotype package 
      of R statistics, respectively. Logistic regression analysis and Fisher's exact 
      test with corrected P (Pc) values were employed for statistical comparisons. 
      RESULTS: FcgammaRIIIa-V158F was associated with the severe form of GBS compared to 
      the mild form (P = 0.005, OR = 2.24, 95% CI = 1.28-3.91; Pc = 0.015); however, 
      FcgammaR genotypes and haplotype patterns did not show any association with GBS 
      susceptibility compared to healthy controls. FcgammaRIIIa-V/V158 and FcgammaRIIIb-NA2/2 
      were associated with recent Campylobacter jejuni infection (P </= 0.001, OR = 0.36, 
      95% CI = 0.23-0.56; Pc </= 0.003 and P = 0.004, OR = 1.70, 95% CI = 1.18-2.44; 
      Pc </= 0.012, respectively). Haplotype 1 (FcgammaRIIa-H131R- FcgammaRIIIa-V158F- 
      FcgammaRIIIb-NA1/2) and the FcgammaRIIIb-NA2/2 genotype were more prevalent among 
      anti-GM1 antibody-positive patients (P = 0.031, OR = 9.61, 95% CI = 1.24-74.77, 
      Pc = 0.279; P = 0.027, OR = 1.62, 95% CI = 1.06-2.5, Pc = 0.081, respectively). 
      INTERPRETATION: FcgammaR polymorphisms and haplotypes are not associated with 
      susceptibility to GBS, though the FcgammaRIIIa-V158F genotype is associated with the 
      severity of GBS.
CI  - (c) 2020 The Authors. Annals of Clinical and Translational Neurology published by 
      Wiley Periodicals LLC on behalf of American Neurological Association.
FAU - Hayat, Shoma
AU  - Hayat S
AD  - Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division 
      (LSSD), icddr,b, Dhaka, 1212, Bangladesh.
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 
      1000, Bangladesh.
FAU - Babu, Golap
AU  - Babu G
AD  - Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division 
      (LSSD), icddr,b, Dhaka, 1212, Bangladesh.
FAU - Das, Avizit
AU  - Das A
AD  - Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division 
      (LSSD), icddr,b, Dhaka, 1212, Bangladesh.
FAU - Howlader, Zakir Hossain
AU  - Howlader ZH
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 
      1000, Bangladesh.
FAU - Mahmud, Ishtiaq
AU  - Mahmud I
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 
      1000, Bangladesh.
FAU - Islam, Zhahirul
AU  - Islam Z
AUID- ORCID: 0000-0003-0935-8079
AD  - Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division 
      (LSSD), icddr,b, Dhaka, 1212, Bangladesh.
LA  - eng
PT  - Journal Article
DEP - 20200602
PL  - United States
TA  - Ann Clin Transl Neurol
JT  - Annals of clinical and translational neurology
JID - 101623278
RN  - 0 (FCGR2A protein, human)
RN  - 0 (FCGR3A protein, human)
RN  - 0 (FCGR3B protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - GPI-Linked Proteins/genetics
MH  - *Genetic Predisposition to Disease
MH  - Guillain-Barre Syndrome/*genetics/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptors, IgG/*genetics
MH  - *Severity of Illness Index
MH  - Young Adult
PMC - PMC7317642
COIS- ZI received funding from the Fogarty International Center, National Institute of 
      Neurological Disorders and Stroke of the National Institutes of Health, USA under 
      Award Number K43 TW011447) and Annexon Biosciences (South San Francisco, CA 
      94080, USA). SH, MGB, AD ZHH and IM have no conflicts of interest to declare.
EDAT- 2020/06/03 06:00
MHDA- 2021/04/20 06:00
PMCR- 2020/06/02
CRDT- 2020/06/03 06:00
PHST- 2020/04/04 00:00 [received]
PHST- 2020/05/11 00:00 [accepted]
PHST- 2020/06/03 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/06/03 06:00 [entrez]
PHST- 2020/06/02 00:00 [pmc-release]
AID - ACN351072 [pii]
AID - 10.1002/acn3.51072 [doi]
PST - ppublish
SO  - Ann Clin Transl Neurol. 2020 Jun;7(6):1040-1049. doi: 10.1002/acn3.51072. Epub 
      2020 Jun 2.