PMID- 32485572
OWN - NLM
STAT- MEDLINE
DCOM- 20210226
LR  - 20210226
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 128
DP  - 2020 Aug
TI  - The effect of candesartan on chronic stress induced imbalance of glucose 
      homeostasis.
PG  - 110300
LID - S0753-3322(20)30492-3 [pii]
LID - 10.1016/j.biopha.2020.110300 [doi]
AB  - OBJECTIVE: To explore whether chronic stress induces imbalance of glucose 
      homeostasis, and to investigate the possible involvement of the renin-angiotensin 
      system (RAS). METHODS: Male Sprague-Dawley rats were divided into four groups: 
      control, chronic stress, chronic stress plus low dose candesartan (an angiotensin 
      II receptor-1 blocker, ARB, 5 mg/kg/d, i.p.), chronic stress plus high dose 
      candesartan (15 mg/kg/d, i.p.). Rats were received restraint stress for 14 days. 
      Glucose transporter 2 (GLUT2) mRNA was quantified in liver by real-time 
      polymerase chain reaction. The concentration of glucokinase (GK), 
      glucose-6-phosphatase (G-6-P), glycogen synthase (GS), insulin receptor (ISR), 
      glucocorticoid receptor (GR)-alpha and -beta in liver, hexokinase (HK), lactate 
      dehydrogenase (LDH) and succinate dehydrogenase (SDH) in muscle, and serum 
      insulin were measured by ELISA. Body weights, systolic blood pressure, heart rate 
      and fasting blood glucose were monitored. Glucose tolerance test were performed 
      after 14 days restraint stress. RESULTS: After 14 days restraint stress, systolic 
      blood pressure, increase of plasma glucose concentration at 15 minutes were 
      higher and the fasting plasma concentration of glucose was lower compared with 
      control group (P <  0.05), which were reversed by high dose ARB treatment (P <  
      0.05). In addition, chronic stress decreased expression of GLUT2 and increased 
      expression of GR beta in liver. High dose ARB treatment normalized GLUT2 and GR 
      beta expressions in liver. CONCLUSIONS: Our present data indicate chronic stress 
      induces the imbalance of glucose homeostasis and RAS contributes to the imbalance 
      of glucose homeostasis induced by chronic stress.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Chen, Ming-Jia
AU  - Chen MJ
AD  - Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, 
      Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China.
FAU - Wei, Yu-Jia
AU  - Wei YJ
AD  - Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, 
      Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China.
FAU - Dong, Xing-Xuan
AU  - Dong XX
AD  - Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, 
      Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China.
FAU - Liu, Jie-Yu
AU  - Liu JY
AD  - Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, 
      Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China.
FAU - Chen, Qiu-Yu
AU  - Chen QY
AD  - Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, 
      Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China.
FAU - Zhang, Guo-Xing
AU  - Zhang GX
AD  - Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, 
      Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China. Electronic 
      address: zhangguoxing@suda.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200530
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Benzimidazoles)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transporter Type 2)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Slc2a2 protein, rat)
RN  - 0 (Tetrazoles)
RN  - S8Q36MD2XX (candesartan)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/*pharmacology
MH  - Animals
MH  - Benzimidazoles/*pharmacology
MH  - Biphenyl Compounds/*pharmacology
MH  - Blood Glucose/*drug effects/metabolism
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Glucose Transporter Type 2/genetics/metabolism
MH  - Hemodynamics/drug effects
MH  - Homeostasis
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Muscle, Skeletal/drug effects/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, Glucocorticoid/genetics/metabolism
MH  - Renin-Angiotensin System/*drug effects
MH  - Restraint, Physical
MH  - *Stress, Physiological
MH  - Stress, Psychological/blood/*drug therapy/etiology
MH  - Tetrazoles/*pharmacology
OTO - NOTNLM
OT  - angiotensin II receptor-1 blocker (ARB)
OT  - glucose metabolism
OT  - renin-angiotensin-system (RAS)
OT  - restraint stress
COIS- Declaration of Competing Interest Authors declare that he/she has no conflict of 
      interest.
EDAT- 2020/06/03 06:00
MHDA- 2021/02/27 06:00
CRDT- 2020/06/03 06:00
PHST- 2020/04/10 00:00 [received]
PHST- 2020/05/16 00:00 [revised]
PHST- 2020/05/20 00:00 [accepted]
PHST- 2020/06/03 06:00 [pubmed]
PHST- 2021/02/27 06:00 [medline]
PHST- 2020/06/03 06:00 [entrez]
AID - S0753-3322(20)30492-3 [pii]
AID - 10.1016/j.biopha.2020.110300 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2020 Aug;128:110300. doi: 10.1016/j.biopha.2020.110300. Epub 
      2020 May 30.