PMID- 32485729
OWN - NLM
STAT- MEDLINE
DCOM- 20210202
LR  - 20221207
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 26
DP  - 2020 Jun 2
TI  - Association Between Monocyte Chemotactic Protein 1 Variants and Age-Related 
      Macular Degeneration Onset Among Chinese People.
PG  - e921584
LID - 10.12659/MSM.921584 [doi]
AB  - BACKGROUND We assessed the potential association between monocyte chemotactic 
      protein 1 (MCP-1) variants (rs1024611 and rs3760396) and age-related macular 
      degeneration (AMD) susceptibility among Chinese Han people. MATERIAL AND METHODS 
      Our research included 129 AMD patients and 131 healthy controls. Genotyping for 
      MCP-1 variants was performed in the 2 groups, and genotype and allele 
      distributions were checked between groups by chi(2) analysis. Odds ratio (OR) and 95% 
      confidence interval (CI) reflected the potential association between MCP-1 
      variants and AMD risk. The linkage disequilibrium of polymorphisms was detected 
      using Haploview. RESULTS Significant differences in rs1024611 genotype 
      distributions were detected between the 2 groups, and homozygous carriers with GG 
      genotype had higher AMD incidence (P<0.05, OR=2.650, 95% CI=1.127-6.231). The 
      rs1024611 G allele frequency was significantly higher in AMD patients, suggesting 
      that the G allele promotes AMD onset (P<0.05, OR=1.447, 95% CI=1.013-2.068). 
      Strong linkage disequilibrium was found between rs1024611 and rs3760396, and 
      haplotype Ars1024611-Crs3760396 was significantly associated with decreased risk 
      of AMD (P=0.001, OR=0.502, 95% CI=0.335-0.752). CONCLUSIONS MCP-1 rs1024611 
      variant appears to contribute to risk of AMD in the Chinese Han population, and 
      the interaction of MCP-1 polymorphisms may also influence individual 
      susceptibility to AMD.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Ophthalmology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Zhao, Guiqiu
AU  - Zhao G
AD  - Department of Ophthalmology, The Affiliated Hospital of Qingdao University, 
      Qingdao, Shandong, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20200602
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics/metabolism
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Macular Degeneration/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
PMC - PMC7291784
EDAT- 2020/06/03 06:00
MHDA- 2021/02/03 06:00
PMCR- 2020/06/02
CRDT- 2020/06/03 06:00
PHST- 2020/06/03 06:00 [entrez]
PHST- 2020/06/03 06:00 [pubmed]
PHST- 2021/02/03 06:00 [medline]
PHST- 2020/06/02 00:00 [pmc-release]
AID - 921584 [pii]
AID - 10.12659/MSM.921584 [doi]
PST - epublish
SO  - Med Sci Monit. 2020 Jun 2;26:e921584. doi: 10.12659/MSM.921584.