PMID- 32487651
OWN - NLM
STAT- MEDLINE
DCOM- 20200615
LR  - 20200615
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 40
IP  - 6
DP  - 2020 Jun
TI  - Clinical Significance of Nucleoli Cytomorphology Assessment in Patients With 
      Uveal Melanoma.
PG  - 3505-3512
LID - 10.21873/anticanres.14338 [doi]
AB  - AIM: To assess the prognostic significance of nucleolar morphological parameters 
      in a large cohort of patients with uveal melanoma. PATIENTS AND METHODS: The 
      presence, size and number of nucleoli of cancer cells were assessed in 
      haematoxylin and eosin (HE)-stained slides of 164 formalin-fixed 
      paraffin-embedded primary uveal melanoma tissue specimens. The results were 
      correlated with clinicopathological features and patient survival. RESULTS: The 
      presence of macronucleoli and multiple nucleoli significantly correlated with the 
      epithelioid type of uveal melanoma, high mitotic rate, and marked pleomorphism. 
      There was a positive correlation between the presence of macronucleoli as well as 
      the number of nucleoli and the largest tumour basal diameter. The increased 
      nucleolus count in tumour cells positively correlated with primary tumour (pT) 
      staging. The presence of both prominent and multiple nucleoli was associated with 
      significantly reduced overall and disease-free survival. CONCLUSION: Histological 
      assessment of nucleolar morphology in routine HE staining would be a helpful 
      low-cost method to obtain reliable prognostic information.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Berus, Tomasz
AU  - Berus T
AD  - Department of Ophthalmology, 4th Military Clinical Hospital with Polyclinic, 
      Wroclaw, Poland tberus@op.pl.
FAU - Markiewicz, Anna
AU  - Markiewicz A
AD  - Department of Ophthalmology and Ocular Oncology, Jagiellonian University Medical 
      College, Krakow, Poland.
FAU - Biecek, Przemyslaw
AU  - Biecek P
AD  - Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Warsaw, 
      Poland.
FAU - Orlowska-Heitzman, Jolanta
AU  - Orlowska-Heitzman J
AD  - Department of Pathomorphology, Jagiellonian University Medical College, Krakow, 
      Poland.
FAU - Halon, Agnieszka
AU  - Halon A
AD  - Department of Pathomorphology and Oncological Cytology, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Romanowska-Dixon, Bozena
AU  - Romanowska-Dixon B
AD  - Department of Ophthalmology and Ocular Oncology, Jagiellonian University Medical 
      College, Krakow, Poland.
FAU - Donizy, Piotr
AU  - Donizy P
AD  - Department of Pathomorphology and Oncological Cytology, Wroclaw Medical 
      University, Wroclaw, Poland.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - Uveal melanoma
SB  - IM
MH  - Aged
MH  - Cell Nucleolus/*pathology/ultrastructure
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Melanoma/mortality/*pathology/ultrastructure
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Tumor Burden
MH  - Uveal Neoplasms/mortality/*pathology/ultrastructure
OTO - NOTNLM
OT  - H&E staining
OT  - Nucleolus
OT  - prognosis
OT  - uveal melanoma
EDAT- 2020/06/04 06:00
MHDA- 2020/06/17 06:00
CRDT- 2020/06/04 06:00
PHST- 2020/04/29 00:00 [received]
PHST- 2020/05/15 00:00 [revised]
PHST- 2020/05/18 00:00 [accepted]
PHST- 2020/06/04 06:00 [entrez]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2020/06/17 06:00 [medline]
AID - 40/6/3505 [pii]
AID - 10.21873/anticanres.14338 [doi]
PST - ppublish
SO  - Anticancer Res. 2020 Jun;40(6):3505-3512. doi: 10.21873/anticanres.14338.