PMID- 32488293
OWN - NLM
STAT- MEDLINE
DCOM- 20210504
LR  - 20210504
IS  - 1439-099X (Electronic)
IS  - 0179-7158 (Linking)
VI  - 197
IP  - 3
DP  - 2021 Mar
TI  - Evaluation of automatic VMAT plans in locally advanced nasopharyngeal carcinoma.
PG  - 177-187
LID - 10.1007/s00066-020-01631-x [doi]
AB  - OBJECTIVE: This study aimed to evaluate the quality of locally advanced 
      nasopharyngeal carcinoma (NPC) radiotherapy plans generated by the automated 
      planning module of a commercial treatment planning system (TPS). METHODS: Data of 
      30 patients with locally advanced NPC were retrospectively investigated. For each 
      patient, volumetric modulated arc therapy (VMAT) plans with double arcs were 
      generated manually by experienced physicists and automatically in the Pinnacle(3) 
      Auto-Planning module (Philips Medical Systems, Fitchburg, WI, USA). The anatomic 
      distance between the second clinical target volume (CTV(2)) and the pons of the 
      brainstem, and the T category of disease were factored into the evaluation. 
      Dosimetric verification was evaluated in terms of gamma pass rate. Target 
      coverage, sparing of organs at risk (OARs), and monitor units were evaluated and 
      compared between the manual and automatic VMAT plans. RESULTS: Not all treatment 
      plans fully met the dose objectives for planning target volumes (PTVs) and OARs, 
      particularly in T4 patients. Overall, automatic VMAT provides a comparable or 
      superior plan quality to manual VMAT in most cases. In stratified analysis, plan 
      quality is mainly independent on T category but is also affected by anatomic 
      distance. If the anatomic distance is less than 5 mm, the automatic VMAT plan 
      quality is equal or even inferior to manual VMAT performed by experienced 
      physicists. Conversely, if the anatomic distance is greater than 5 mm, the 
      automatic VMAT plan quality is superior to manual VMAT. Gamma pass rates for 
      quality assurance are similar between manual and automatic VMAT plans for the 
      former case, but significantly higher in automatic VMAT for the latter. 
      CONCLUSION: The selection of manual versus automatic VMAT planning in locally 
      advanced NPC should be made individually based on the anatomic distance, rather 
      than blindly and habitually, since automatic VMAT is not good enough to 
      completely replace manual VMAT.
FAU - Zhang, Quanbin
AU  - Zhang Q
AD  - Radiotherapy center, Affiliated Cancer Hospital & Institute of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Ou, Liya
AU  - Ou L
AD  - Guangzhou Medical University, Guangzhou, China. 644170008@qq.com.
FAU - Peng, Yingying
AU  - Peng Y
AD  - Radiotherapy center, Affiliated Cancer Hospital & Institute of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Yu, Hui
AU  - Yu H
AD  - Radiotherapy center, Affiliated Cancer Hospital & Institute of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Wang, Linjing
AU  - Wang L
AD  - Radiotherapy center, Affiliated Cancer Hospital & Institute of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Zhang, Shuxu
AU  - Zhang S
AUID- ORCID: 0000-0001-9416-0782
AD  - Radiotherapy center, Affiliated Cancer Hospital & Institute of Guangzhou Medical 
      University, Guangzhou, China. gthzsx@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200602
PL  - Germany
TA  - Strahlenther Onkol
JT  - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et 
      al]
JID - 8603469
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Carcinoma/*radiotherapy
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Nasopharyngeal carcinoma
OT  - Organs at risk
OT  - Quality of life
OT  - Radiotherapy planning, computer-assisted
OT  - Radiotherapy, intensity modulated
EDAT- 2020/06/04 06:00
MHDA- 2021/05/05 06:00
CRDT- 2020/06/04 06:00
PHST- 2020/01/28 00:00 [received]
PHST- 2020/05/04 00:00 [accepted]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2021/05/05 06:00 [medline]
PHST- 2020/06/04 06:00 [entrez]
AID - 10.1007/s00066-020-01631-x [pii]
AID - 10.1007/s00066-020-01631-x [doi]
PST - ppublish
SO  - Strahlenther Onkol. 2021 Mar;197(3):177-187. doi: 10.1007/s00066-020-01631-x. 
      Epub 2020 Jun 2.