PMID- 32488585
OWN - NLM
STAT- MEDLINE
DCOM- 20210503
LR  - 20211007
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 120
IP  - 7
DP  - 2020 Jul
TI  - Effects of recreational scuba diving on erythropoiesis-"normobaric oxygen 
      paradox" or "plasma volume regulation" as a trigger for erythropoietin?
PG  - 1689-1697
LID - 10.1007/s00421-020-04395-5 [doi]
AB  - PURPOSE: Previous studies have shown an increase in erythrocyte lipid 
      peroxidation and a decrease in red blood cell (RBC) count, hemoglobin, and 
      hematocrit after only one recreational scuba diving session. The aim of this 
      study was to examine the effect of repetitive scuba diving on RBC parameters and 
      erythropoiesis. METHODS: Divers (N = 14) conducted one dive per week over 5 weeks 
      at a depth of 20-30 m for 30 min. For measuring RBC parameters, erythropoietin, 
      iron, and ferritin, blood samples were collected before and after the first, 
      third, and fifth dive. RESULTS: Between pre- and post-dive results, a 
      statistically significant increase in RBC count, hemoglobin, hematocrit, mean 
      corpuscular volume (MCV), RBC distribution width (RDW), iron, and ferritin was 
      observed. Analysis of the results between the first, third, and fifth dive showed 
      that the erythropoietin increase at the third (pre-dive p = 0.009; post-dive 
      p = 0.004) and fifth dive (pre-dive p < 0.001; post-dive p = 0.003) was not 
      accompanied by changes in RBC count, hemoglobin, iron, and ferritin. In parallel, 
      a continuous increase in hematocrit, MCV, and RDW was observed, whereas mean 
      corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) 
      decreased. CONCLUSIONS: Changes in RBC indices and EPO elevation indicate that 
      the occasional switch from hyperoxia to normoxia or mechanisms for plasma volume 
      regulation may be a step in the maintenance of erythropoiesis.
FAU - Perovic, Antonija
AU  - Perovic A
AUID- ORCID: 0000-0002-2633-3669
AD  - Department of Laboratory Diagnostics, Dubrovnik General Hospital, Dr. Roka 
      Misetica 2, 20000, Dubrovnik, Croatia. perovic.antonija@gmail.com.
FAU - Zarak, Marko
AU  - Zarak M
AUID- ORCID: 0000-0001-6768-9218
AD  - University Department of Laboratory Diagnostics, Dubrava University Hospital, 
      Zagreb, Croatia.
FAU - Njire Braticevic, Marina
AU  - Njire Braticevic M
AUID- ORCID: 0000-0001-8629-3008
AD  - Department of Laboratory Diagnostics, Dubrovnik General Hospital, Dr. Roka 
      Misetica 2, 20000, Dubrovnik, Croatia.
FAU - Dumic, Jerka
AU  - Dumic J
AUID- ORCID: 0000-0002-6822-134X
AD  - Faculty of Pharmacy and Biochemistry, Department of Biochemistry and Molecular 
      Biology, University of Zagreb, Zagreb, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20200601
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (EPO protein, human)
RN  - 0 (Hemoglobins)
RN  - 11096-26-7 (Erythropoietin)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Diving/*physiology
MH  - Erythrocyte Count/methods
MH  - Erythropoiesis/*physiology
MH  - Erythropoietin/blood/metabolism
MH  - Ferritins/*blood
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Iron/blood/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Plasma Volume/*physiology
OTO - NOTNLM
OT  - Erythropoiesis
OT  - Erythropoietin
OT  - Hyperoxia
OT  - Red blood cells
OT  - Scuba diving
EDAT- 2020/06/04 06:00
MHDA- 2021/05/04 06:00
CRDT- 2020/06/04 06:00
PHST- 2020/02/18 00:00 [received]
PHST- 2020/05/12 00:00 [accepted]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2021/05/04 06:00 [medline]
PHST- 2020/06/04 06:00 [entrez]
AID - 10.1007/s00421-020-04395-5 [pii]
AID - 10.1007/s00421-020-04395-5 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2020 Jul;120(7):1689-1697. doi: 10.1007/s00421-020-04395-5. 
      Epub 2020 Jun 1.