PMID- 32488958
OWN - NLM
STAT- MEDLINE
DCOM- 20201006
LR  - 20210110
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 34
IP  - 9
DP  - 2020 Sep
TI  - Analysis of clinical features and outcomes of 161 patients with severe and 
      critical COVID-19: A multicenter descriptive study.
PG  - e23415
LID - 10.1002/jcla.23415 [doi]
LID - e23415
AB  - BACKGROUND: This study aimed to investigate clinical characteristics, laboratory 
      indexes, treatment regimens, and short-term outcomes of severe and critical 
      coronavirus disease 2019 (COVID-19) patients. METHODS: One hundred and sixty one 
      consecutive severe and critical COVID-19 patients admitted in intensive care unit 
      (ICU) were retrospectively reviewed in this multicenter study. Demographic 
      features, medical histories, clinical symptoms, lung computerized tomography (CT) 
      findings, and laboratory indexes on admission were collected. Post-admission 
      complications, treatment regimens, and clinical outcomes were also documented. 
      RESULTS: The mean age was 59.38 +/- 16.54 years, with 104 (64.60%) males and 57 
      (35.40%) females. Hypertension (44 [27.33%]) and diabetes were the most common 
      medical histories. Fever (127 [78.88%]) and dry cough (111 [68.94%]) were the 
      most common symptoms. Blood routine indexes, hepatic and renal function indexes, 
      and inflammation indexes were commonly abnormal. Acute respiratory distress 
      syndrome (ARDS) was the most common post-admission complication (69 [42.86%]), 
      followed by electrolyte disorders (48 [29.81%]), multiple organ dysfunction 
      (MODS) (37 [22.98%]), and hypoproteinemia (36 [22.36%]). The most commonly used 
      antiviral drug was lopinavir/ritonavir tablet. 50 (31.06%) patients died, while 
      78 (48.45%) patients healed and discharged, and the last 33 (20.50%) patients 
      remained in hospital. Besides, the mean hospital stay of deaths was 
      21.66 +/- 11.18 days, while the mean hospital stay of discharged patients was 
      18.42 +/- 12.77 days. Furthermore, ARDS (P < .001) and MODS (P = .008) correlated 
      with increased mortality rate. CONCLUSION: Severe and critical COVID-19 presents 
      with high mortality rate, and occurrence of ARDS or MODS greatly increases its 
      mortality risk.
CI  - (c) 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Shi, Ming
AU  - Shi M
AD  - Department of Respiratory Medicine, Affiliated Dongfeng Hospital, Hubei 
      University of Medicine, Shiyan, China.
FAU - Chen, Lianhua
AU  - Chen L
AD  - Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, 
      Shiyan, China.
FAU - Yang, Yadong
AU  - Yang Y
AD  - Department of Critical Care Medicine, Huanggang Central Hospital, Huanggang, 
      China.
FAU - Zhang, Jingpeng
AU  - Zhang J
AD  - Department of Critical Care Medicine, Huanggang Central Hospital, Huanggang, 
      China.
FAU - Xu, Ji
AU  - Xu J
AD  - Departmen of Critical Care Medicine, Qichun People's Hospital, Qichun, China.
FAU - Xu, Gang
AU  - Xu G
AD  - Department of Critical Care Medicine, Wuxue People's Hospital, Wuxue, China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Medical Laboratory, Huanggang Central Hospital, Huanggang, China.
FAU - Yin, Yiping
AU  - Yin Y
AUID- ORCID: 0000-0002-2288-4260
AD  - Department of Respiratory Medicine, Renmin Hospital, Hubei University of 
      Medicine, Shiyan, 442000, China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200602
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Betacoronavirus/*physiology
MH  - COVID-19
MH  - Coronavirus Infections/complications/mortality/*pathology/*therapy
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pandemics
MH  - Pneumonia, Viral/complications/mortality/*pathology/*therapy
MH  - SARS-CoV-2
MH  - *Severity of Illness Index
MH  - Treatment Outcome
PMC - PMC7300573
OTO - NOTNLM
OT  - COVID-19
OT  - clinical features
OT  - clinical outcomes
OT  - laboratory indexes
OT  - post-admission complications
EDAT- 2020/06/04 06:00
MHDA- 2020/10/07 06:00
PMCR- 2020/06/02
CRDT- 2020/06/04 06:00
PHST- 2020/05/06 00:00 [received]
PHST- 2020/05/18 00:00 [accepted]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2020/10/07 06:00 [medline]
PHST- 2020/06/04 06:00 [entrez]
PHST- 2020/06/02 00:00 [pmc-release]
AID - JCLA23415 [pii]
AID - 10.1002/jcla.23415 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2020 Sep;34(9):e23415. doi: 10.1002/jcla.23415. Epub 2020 Jun 2.