PMID- 32490016
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2322-4436 (Print)
IS  - 2322-3219 (Electronic)
IS  - 2322-3219 (Linking)
VI  - 9
IP  - 2
DP  - 2020 Summer
TI  - A Review of Last Decade Developments on Epiretinal Membrane Pathogenesis.
PG  - 91-110
AB  - Epiretinal membrane (ERM) is a pathologic tissue that develops at the 
      vitreoretinal interface. ERM is responsible for pathological changes of vision 
      with varying degrees of clinical significance. It is either idiopathic or 
      secondary to a wide variety of diseases such as proliferative diabetic 
      retinopathy (PDR) and proliferative vitreoretinopathy (PVR). A great variation in 
      the prevalence of idiopathic ERM among different ethnic groups proposed that 
      genetic and lifestyle factors may play a role in ERM occurrence. 
      Histopathological studies demonstrate that various cell types including retinal 
      pigment epithelium (RPE) cells, fibrocytes, fibrous astrocytes, 
      myofibroblast-like cells, glial cells, endothelial cells (ECs) and macrophages, 
      as well as trophic and transcription factors, including transforming growth 
      factor (TGF), vascular endothelial growth factor (VEGF), platelet-derived growth 
      factor (PDGF) etc., are directly or indirectly involved in the pathogenesis of 
      idiopathic or secondary ERMs. These processes are driven (on the last count) by 
      more than 50 genes, such as Tumor Necrosis Factor (TNF), CCL2 (chemokine (C-C 
      motif) ligand )), Metastasis Associated Lung Adenocarcinoma Transcript 1 
      )MALAT1(, transforming growth factor (TGF)-beta1, TGF-beta2, Interleukin-6 (IL-6), 
      IL-10, VEGF and glial fibrillary acidic protein (GFAP), some of which have been 
      studied more intensely than others. The present paper tried to summarize, 
      highlight and cross-correlate the major findings made in the last decade on the 
      function of these genes and their association with different types of cells, 
      genes and gene expression products in the ERM formation.
CI  - Copyright (c) 2020, Author(s).
FAU - Tsotridou, Eleni
AU  - Tsotridou E
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
AD  - Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Loukovitis, Eleftherios
AU  - Loukovitis E
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
AD  - Department of Ophthalmology, 424 General Military Hospital, Thessaloniki, Greece.
FAU - Zapsalis, Konstantinos
AU  - Zapsalis K
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
AD  - Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Pentara, Iro
AU  - Pentara I
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
AD  - Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Asteriadis, Solon
AU  - Asteriadis S
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
FAU - Tranos, Paris
AU  - Tranos P
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
FAU - Zachariadis, Zachos
AU  - Zachariadis Z
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
FAU - Anogeianakis, George
AU  - Anogeianakis G
AD  - Ophthalmica Eye Institute, Thessaloniki, Greece.
AD  - Association for Training in Biomedical Technology, Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200320
PL  - United States
TA  - Med Hypothesis Discov Innov Ophthalmol
JT  - Medical hypothesis, discovery & innovation ophthalmology journal
JID - 101611331
PMC - PMC7134239
OTO - NOTNLM
OT  - Cell types
OT  - ERM
OT  - Epiretinal Membrane
OT  - Idiopathic
OT  - Pathogenesis
OT  - Secondary
OT  - Transcription Factors
OT  - Trophic Factors
EDAT- 2020/06/04 06:00
MHDA- 2020/06/04 06:01
PMCR- 2020/06/01
CRDT- 2020/06/04 06:00
PHST- 2020/06/04 06:00 [entrez]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2020/06/04 06:01 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - mehdiophth-9-091 [pii]
PST - ppublish
SO  - Med Hypothesis Discov Innov Ophthalmol. 2020 Summer;9(2):91-110. Epub 2020 Mar 
      20.