PMID- 32490237
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 6
IP  - 5
DP  - 2020 May
TI  - Neuroprotective and memory-enhancing effects of methanolic leaf extract of 
      Peristrophe bicalyculata in rat model of type 2 diabetes mellitus.
PG  - e04011
LID - 10.1016/j.heliyon.2020.e04011 [doi]
LID - e04011
AB  - This study investigated the effect of methanolic leaf extract of Peristrophe 
      Bicalyculata (MEPb) on type 2 diabetes mellitus (T2DM) associated cognitive 
      decline in Wistar rats. 36 male rats weighing 130-200 g were assigned into 6 
      groups (n = 6) as follows: normal control, diabetic control, pioglitazone-treated 
      diabetic and three MEPb-treated diabetic groups, type 2 diabetes mellitus was 
      induced with low dose streptozocin (STZ) injection following 3 weeks of high fat 
      diet (HFD) intake. Thirty days after diabetes induction, rats exhibited marked 
      and persistent hyperglycemia, animals were treated with MEPb (50, 100 and 200 
      mg/kg) and pioglitazone (10 mg/kg) as standard. Morris water maze (MWM) test and 
      Novel object recognition test (NORT) were used to assess learning and memory. 
      Blood glucose level, oxidative stress makers, pro-inflammatory marker and 
      acetylcholinestarase activities were analysed. Both MEPb and pioglitazone 
      significantly (P < 0.05) reduced escape latency in treated animals compared to 
      the diabetic control group in the MWM test. Methanolic leaf extract of 
      Peristrophe bicalyculata and pioglitazone also significantly (P < 0.05) increased 
      discrimination index in treated animals compared to the diabetic control group in 
      the novel object recognition test. Serum, brain and liver MDA levels were 
      significantly (P < 0.05) decreased in MEPb and pioglitazone treated rats compared 
      to diabetic control. Serum and liver GSH as well as CAT levels were significantly 
      (P < 0.05) increased while brain GSH and CAT levels shows apparent increase in 
      MEPb and pioglitazone treated rats compared with diabetic control. Treatment with 
      MEPb caused a significant (P < 0.05) decrease in brain nitrite level, interleukin 
      6 and acetylcholinesterase activity compared to diabetic control group. We 
      conclude that Methanolic leaf extract of Peristrophe bicalyculata enhanced 
      antioxidant capacity and prevented neuroinflammation, consequently improving 
      brain neuronal cholinergic function in experimental animals.
CI  - (c) 2020 The Author(s).
FAU - Njan, Anoka A
AU  - Njan AA
AD  - Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, 
      University of Ilorin, Ilorin, Nigeria.
FAU - Adenuga, Francisca O
AU  - Adenuga FO
AD  - Neuropharmacology and Ethnopharmacology Unit, Department of Pharmacology and 
      Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University 
      of Ibadan, Ibadan, Nigeria.
FAU - Ajayi, Abayomi M
AU  - Ajayi AM
AD  - Neuropharmacology and Ethnopharmacology Unit, Department of Pharmacology and 
      Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University 
      of Ibadan, Ibadan, Nigeria.
FAU - Sotunde, Olasubomi
AU  - Sotunde O
AD  - Neuropharmacology and Ethnopharmacology Unit, Department of Pharmacology and 
      Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University 
      of Ibadan, Ibadan, Nigeria.
FAU - Ologe, Mary O
AU  - Ologe MO
AD  - Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, 
      University of Ilorin, Ilorin, Nigeria.
FAU - Olaoye, Solomon O
AU  - Olaoye SO
AD  - General Hospital, Kishi, Oyo State, Nigeria.
FAU - Erdogan, Ozlem Nazan
AU  - Erdogan ON
AD  - Department of Pharmacy Management, School of Pharmacy, Istanbul University, 
      Beyazit, Istanbul 34116, Turkey.
FAU - Iwalewa, Olugbenga E
AU  - Iwalewa OE
AD  - Neuropharmacology and Ethnopharmacology Unit, Department of Pharmacology and 
      Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University 
      of Ibadan, Ibadan, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20200522
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC7256363
OTO - NOTNLM
OT  - Alternative medicine
OT  - Diabetes
OT  - Diabetes mellitus
OT  - Endocrinology
OT  - Health sciences
OT  - Natural product chemistry
OT  - Neuroprotection
OT  - Oxidative stress
OT  - Peristrophe bicalyculata
OT  - Pharmaceutical science
OT  - Physiology
OT  - Pioglitazone
EDAT- 2020/06/04 06:00
MHDA- 2020/06/04 06:01
PMCR- 2020/05/22
CRDT- 2020/06/04 06:00
PHST- 2019/11/18 00:00 [received]
PHST- 2020/02/04 00:00 [revised]
PHST- 2020/05/14 00:00 [accepted]
PHST- 2020/06/04 06:00 [entrez]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2020/06/04 06:01 [medline]
PHST- 2020/05/22 00:00 [pmc-release]
AID - S2405-8440(20)30855-0 [pii]
AID - e04011 [pii]
AID - 10.1016/j.heliyon.2020.e04011 [doi]
PST - epublish
SO  - Heliyon. 2020 May 22;6(5):e04011. doi: 10.1016/j.heliyon.2020.e04011. eCollection 
      2020 May.