PMID- 32491181
OWN - NLM
STAT- MEDLINE
DCOM- 20210208
LR  - 20210208
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 105
IP  - 8
DP  - 2020 Aug 1
TI  - Effect of Vitamin D Supplementation on the Incidence of Diabetes Mellitus.
LID - dgaa335 [pii]
LID - 10.1210/clinem/dgaa335 [doi]
AB  - CONTEXT: The effect of vitamin D supplementation on the risk of type 2 diabetes 
      mellitus (T2DM) remains controversial because most randomized controlled trials 
      (RCTs) have been small or have reported low doses of vitamin D. OBJECTIVE: To 
      conduct a meta-analysis of RCTs testing vitamin D supplementation in the 
      prevention of T2DM. DATA SOURCES: Database search of PubMed/MEDLINE, EMBASE, and 
      the Cochrane Library was performed by 2 reviewers from inception through 
      September 15, 2019. STUDY SELECTION: We included RCTs that reported the effect of 
      vitamin D supplementation for at least 1 year on T2DM prevention. DATA 
      EXTRACTION: Two independent reviewers extracted the data. The risk ratios (RRs) 
      and 95% confidence intervals (CIs) were reported. Primary outcome of the 
      meta-analysis was the incidence of T2DM. DATA SYNTHESIS: Nine RCTs were included 
      (43 559 participants). The mean age (standard deviation) was 63.5 (6.7) years. 
      The RR for vitamin D compared with placebo was 0.96 (95% CI, 0.90-1.03); P = 
      0.30. In trials testing moderate to high doses of supplementation (>/=1000 IU/day), 
      all conducted among participants with prediabetes, the RR for vitamin D compared 
      with placebo was 0.88 (95% CI, 0.79-0.99). In contrast, the trials testing lower 
      doses, which were conducted in general population samples, showed no risk 
      reduction (RR, 1.02; 95% CI, 0.94-1.10; P, interaction by dose = 0.04). 
      CONCLUSION: In patients with prediabetes, vitamin D supplementation at moderate 
      to high doses (>/=1000 IU/day), significantly reduced the incidence risk of T2DM, 
      compared with placebo.
CI  - (c) Endocrine Society 2020. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Barbarawi, Mahmoud
AU  - Barbarawi M
AD  - Department of Internal Medicine, Hurley Medical Center/Michigan State University, 
      Flint, MI, USA.
FAU - Zayed, Yazan
AU  - Zayed Y
AD  - Department of Internal Medicine, Hurley Medical Center/Michigan State University, 
      Flint, MI, USA.
FAU - Barbarawi, Owais
AU  - Barbarawi O
AD  - Department of Internal Medicine, Mutah University, Al-Karak, Jordan.
FAU - Bala, Areeg
AU  - Bala A
AD  - Department of Internal Medicine, Hurley Medical Center/Michigan State University, 
      Flint, MI, USA.
FAU - Alabdouh, Ahmad
AU  - Alabdouh A
AD  - Department of Internal Medicine, Saint Agnes Hospital, Baltimore, MD, USA.
FAU - Gakhal, Inderdeep
AU  - Gakhal I
AD  - Department of Internal Medicine, Hurley Medical Center/Michigan State University, 
      Flint, MI, USA.
FAU - Rizk, Fatima
AU  - Rizk F
AD  - Michigan State University, College of Osteopathic Medicine, East Lansing, MI, 
      USA.
FAU - Alkasasbeh, Mariam
AU  - Alkasasbeh M
AD  - Department of Nutrition, University of Jordan, Amman, Jordan.
FAU - Bachuwa, Ghassan
AU  - Bachuwa G
AD  - Department of Internal Medicine, Hurley Medical Center/Michigan State University, 
      Flint, MI, USA.
FAU - Manson, JoAnn E
AU  - Manson JE
AD  - Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 
      Boston, MA, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Placebos)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*epidemiology/prevention & control
MH  - *Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Incidence
MH  - Placebos/administration & dosage
MH  - Prediabetic State/*diet therapy
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
MH  - Vitamin D/*administration & dosage
OTO - NOTNLM
OT  - body mass index
OT  - diabetes mellitus
OT  - meta-analysis
OT  - prediabetes
OT  - vitamin D
EDAT- 2020/06/04 06:00
MHDA- 2021/02/09 06:00
CRDT- 2020/06/04 06:00
PHST- 2020/01/15 00:00 [received]
PHST- 2020/03/03 00:00 [revised]
PHST- 2020/05/26 00:00 [accepted]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2021/02/09 06:00 [medline]
PHST- 2020/06/04 06:00 [entrez]
AID - 5850844 [pii]
AID - 10.1210/clinem/dgaa335 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2020 Aug 1;105(8):dgaa335. doi: 10.1210/clinem/dgaa335.