PMID- 32492677
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 117
IP  - 4
DP  - 2020
TI  - Prediction of Neurodevelopmental Impairment in Congenital Cytomegalovirus 
      Infection by Early Postnatal Magnetic Resonance Imaging.
PG  - 460-466
LID - 10.1159/000508218 [doi]
AB  - INTRODUCTION: Congenital cytomegalovirus infection (CCMVI) may result in 
      neurodevelopmental impairments (NDIs) such as hearing loss, developmental delay, 
      epilepsy, and cerebral palsy. We aimed to investigate the potential for brain 
      magnetic resonance imaging (MRI) to predict NDI in patients with CCMVI. METHODS: 
      We studied infants with CCMVI who were referred to our hospital from April 2010 
      to October 2018 and underwent a brain MRI within 3 months since birth. We 
      screened for 6 classic presentations of CCMVI including ventriculomegaly, 
      periventricular cysts, hippocampal dysplasia, cerebellar hypoplasia, migration 
      disorders, and white matter abnormalities. Images were interpreted by a blinded 
      pediatric radiologist. NDI was defined as having a developmental quotient <80, 
      hearing dysfunction, blindness, or epilepsy requiring anti-epileptic drugs at 
      approximately 18 months of corrected age. RESULTS: The study involved 42 infants 
      with CCMVI (median gestational age 38 weeks, birthweight 2,516 g). At least one 
      abnormal finding was detected in 28 (67%) infants. Abnormal findings consisted of 
      3 cerebellar hypoplasia (7%), 7 migration disorders (17%), 26 white matter 
      abnormalities (62%), 12 periventricular cysts (28%), 1 hippocampal dysplasia 
      (2%), and 20 ventriculomegaly (48%). Abnormal findings were significantly more 
      prevalent in infants with clinical symptoms (21/24, 91%) than in those without 
      (7/19, 37%, p < 0.01). For NDI prediction, having >/=2 of ventriculomegaly, 
      periventricular cysts, and white matter abnormality produced the highest Youden 
      index values (0.78). CONCLUSION: Infants with CCMVI with at least 2 of the 
      abovementioned specific brain image abnormalities may be at high risk of 
      developing NDI.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Nishida, Kosuke
AU  - Nishida K
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Fujioka, Kazumichi
AU  - Fujioka K
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan, fujiokak@med.kobe-u.ac.jp.
FAU - Sugioka, Yusuke
AU  - Sugioka Y
AD  - Department of Radiology, Kobe Children's Hospital, Kobe, Japan.
FAU - Abe, Shinya
AU  - Abe S
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Ashina, Mariko
AU  - Ashina M
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Fukushima, Sachiyo
AU  - Fukushima S
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Ohyama, Shohei
AU  - Ohyama S
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Ikuta, Toshihiko
AU  - Ikuta T
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Tanimura, Kenji
AU  - Tanimura K
AD  - Department of Obstetrics and Gynecology, Kobe University Graduate School of 
      Medicine, Kobe, Japan.
FAU - Yamada, Hideto
AU  - Yamada H
AD  - Department of Obstetrics and Gynecology, Kobe University Graduate School of 
      Medicine, Kobe, Japan.
FAU - Iijima, Kazumoto
AU  - Iijima K
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Morioka, Ichiro
AU  - Morioka I
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200603
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Brain Diseases
MH  - Child
MH  - *Cytomegalovirus Infections/diagnostic imaging
MH  - Humans
MH  - Infant
MH  - Magnetic Resonance Imaging
MH  - *White Matter/diagnostic imaging
OTO - NOTNLM
OT  - Congenital cytomegalovirus infection
OT  - Early neonatal period
OT  - Magnetic resonance imaging
OT  - Neurodevelopmental outcome
OT  - Perinatal risk factors
EDAT- 2020/06/04 06:00
MHDA- 2021/09/01 06:00
CRDT- 2020/06/04 06:00
PHST- 2019/12/25 00:00 [received]
PHST- 2020/04/26 00:00 [accepted]
PHST- 2020/06/04 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2020/06/04 06:00 [entrez]
AID - 000508218 [pii]
AID - 10.1159/000508218 [doi]
PST - ppublish
SO  - Neonatology. 2020;117(4):460-466. doi: 10.1159/000508218. Epub 2020 Jun 3.