PMID- 32493079
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1552-695X (Electronic)
IS  - 1534-7354 (Print)
IS  - 1534-7354 (Linking)
VI  - 19
DP  - 2020 Jan-Dec
TI  - Factors Influencing Functional Exercise Capacity After Lung Resection for 
      Non-Small Cell Lung Cancer.
PG  - 1534735420923389
LID - 10.1177/1534735420923389 [doi]
LID - 1534735420923389
AB  - Purpose: We investigated, in patients who underwent lung resection for non-small 
      cell lung cancer (NSCLC), the magnitude of early limitation in functional 
      exercise capacity and the associations with pre- and postoperative factors. 
      Methods: Consecutive patients with preoperative clinical stage I to IIIA NSCLC 
      who underwent lung resection were prospectively enrolled. We measured functional 
      exercise capacity (6-minute walk distance [6MWD]) and skeletal muscle strength 
      (handgrip [HF] and quadriceps force [QF]) within 2 days prior to surgery and on 
      day 7 postoperatively. Results: Two hundred eighteen participants were recruited 
      (median age 69 years) of whom 49 developed postoperative complications (POCs). 
      6MWD was markedly decreased (514 m vs 469 m, P < .001); HF and QF were slightly 
      decreased following surgery. Multiple linear regression showed that preoperative 
      vital capacity (P < .01), QF (P < .05), the duration of chest tube drainage (P < 
      .001), and presence of POCs (P < .05) were significant predictors. However, 
      intraoperative factors were not significantly associated with the decline in 
      6MWD. Conclusions: These results suggest that patients with preoperative 
      impairments in pulmonary function and muscle strength, and those who require 
      prolonged chest tube drainage or develop POCs are likely to have impaired 
      exercise capacity. Therefore, individual assessment and follow-up of patients 
      with such factors is indicated.
FAU - Oikawa, Masato
AU  - Oikawa M
AUID- ORCID: 0000-0001-9648-7201
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
AD  - Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, 
      Japan.
FAU - Hanada, Masatoshi
AU  - Hanada M
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
AD  - Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, 
      Japan.
FAU - Nagura, Hiroki
AU  - Nagura H
AD  - Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, 
      Japan.
FAU - Tsuchiya, Tomoshi
AU  - Tsuchiya T
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
FAU - Matsumoto, Keitaro
AU  - Matsumoto K
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
FAU - Miyazaki, Takuro
AU  - Miyazaki T
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
FAU - Sawai, Terumitsu
AU  - Sawai T
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
FAU - Yamasaki, Naoya
AU  - Yamasaki N
AD  - Shimizu Hospital, Nagasaki, Japan.
FAU - Nagayasu, Takeshi
AU  - Nagayasu T
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
FAU - Kozu, Ryo
AU  - Kozu R
AD  - Department of Cardiopulmonary Rehabilitation Science, Nagasaki University 
      Graduate School of Biomedical Sciences, Nagasaki, Japan.
AD  - Department of Rehabilitation Medicine, Nagasaki University Hospital, Nagasaki, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Integr Cancer Ther
JT  - Integrative cancer therapies
JID - 101128834
SB  - IM
MH  - Aged
MH  - *Carcinoma, Non-Small-Cell Lung/surgery
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Hand Strength
MH  - Humans
MH  - Lung
MH  - *Lung Neoplasms/surgery
PMC - PMC7273541
OTO - NOTNLM
OT  - 6-minute walk distance
OT  - exercise capacity
OT  - lung resection
OT  - muscle strength
OT  - non-small cell lung cancer
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2020/06/05 06:00
MHDA- 2021/08/19 06:00
PMCR- 2020/06/04
CRDT- 2020/06/05 06:00
PHST- 2020/06/05 06:00 [entrez]
PHST- 2020/06/05 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/06/04 00:00 [pmc-release]
AID - 10.1177_1534735420923389 [pii]
AID - 10.1177/1534735420923389 [doi]
PST - ppublish
SO  - Integr Cancer Ther. 2020 Jan-Dec;19:1534735420923389. doi: 
      10.1177/1534735420923389.