PMID- 32494886 OWN - NLM STAT- MEDLINE DCOM- 20200805 LR - 20200805 IS - 1432-0703 (Electronic) IS - 0090-4341 (Linking) VI - 79 IP - 2 DP - 2020 Aug TI - Levels of Perfluoroalkyl Acids (PFAAs) in Human Serum, Hair and Nails in Guangdong Province, China: Implications for Exploring the Ideal Bio-Indicator. PG - 184-194 LID - 10.1007/s00244-020-00743-w [doi] AB - The widespread human exposure to perfluoroalkyl acids (PFAAs) has led to increasing public concern. In this study, we present a comprehensive measurement of total fluorine (TF), extractable organic fluorine (EOF), identified organic fluorine (IOF, total concentration of identified PFAAs quantified as fluorine) and 11 target PFAAs in human serum (n = 60), hair (n = 49) and nails (n = 39) collected from non-occupation exposed volunteers in 10 cities of Guangdong Province, China. The results indicated that EOF was the major form of fluorine in serum, accounting for 70-80% of TF. The levels of IOF contributed less than 10% of EOF. Perfluorooctane sulfonic acid (PFOS) was found to be the dominant PFAA with mean concentration of 23 ng.mL(-1) in serum, 35 ng.g(-1) in hair and 33 ng.g(-1) in nail, respectively. Short-chain PFAAs (C