PMID- 32499305
OWN - NLM
STAT- MEDLINE
DCOM- 20210406
LR  - 20221115
IS  - 1600-0617 (Electronic)
IS  - 0905-9180 (Print)
IS  - 0905-9180 (Linking)
VI  - 29
IP  - 156
DP  - 2020 Jun 30
TI  - Minimal clinically important difference for asthma endpoints: an expert consensus 
      report.
LID - 10.1183/16000617.0137-2019 [doi]
LID - 190137
AB  - Minimal clinically important difference (MCID) can be defined as the smallest 
      change or difference in an outcome measure that is perceived as beneficial and 
      would lead to a change in the patient's medical management.The aim of the current 
      expert consensus report is to provide a "state-of-the-art" review of the 
      currently available literature evidence about MCID for end-points to monitor 
      asthma control, in order to facilitate optimal disease management and identify 
      unmet needs in the field to guide future research.A series of MCID cut-offs are 
      currently available in literature and validated among populations of asthmatic 
      patients, with most of the evidence focusing on outcomes as patient reported 
      outcomes, lung function and exercise tolerance. On the contrary, only scant and 
      partial data are available for inflammatory biomarkers. These clearly represent 
      the most interesting target for future development in diagnosis and clinical 
      management of asthma, particularly in view of the several biologic drugs in the 
      pipeline, for which regulatory agencies will soon require personalised proof of 
      efficacy and treatment response predictors.
CI  - Copyright (c)ERS 2020.
FAU - Bonini, Matteo
AU  - Bonini M
AD  - National Heart and Lung Institute, Royal Brompton Hospital & Imperial College 
      London, London, UK.
AD  - UOC Pneumologia, Istituto di Medicina Interna, F. Policlinico Gemelli IRCCS, 
      Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Di Paolo, Marcello
AU  - Di Paolo M
AUID- ORCID: 0000-0001-9123-1389
AD  - National Heart and Lung Institute, Royal Brompton Hospital & Imperial College 
      London, London, UK.
FAU - Bagnasco, Diego
AU  - Bagnasco D
AD  - Allergy and Respiratory diseases, University of Genoa, Dept of Internal Medicine 
      (DiMI), Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Baiardini, Ilaria
AU  - Baiardini I
AD  - Dept of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
FAU - Braido, Fulvio
AU  - Braido F
AD  - Allergy and Respiratory diseases, University of Genoa, Dept of Internal Medicine 
      (DiMI), Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Caminati, Marco
AU  - Caminati M
AD  - Dept of Medicine, University of Verona, Verona, Italy.
AD  - Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.
FAU - Carpagnano, Elisiana
AU  - Carpagnano E
AD  - Division of Respiratory Diseases, Dept of Medical and Surgical Sciences, 
      University of Foggia, Italy.
FAU - Contoli, Marco
AU  - Contoli M
AD  - Section of Internal and Cardiorespiratory Medicine, Dept of Medical Sciences, 
      University of Ferrara, Ferrara, Italy.
FAU - Corsico, Angelo
AU  - Corsico A
AD  - Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation - Dept 
      of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
FAU - Del Giacco, Stefano
AU  - Del Giacco S
AUID- ORCID: 0000-0002-4517-1749
AD  - Dept of Medical Sciences and Public Health, University of Cagliari, Cagliari, 
      Italy.
FAU - Heffler, Enrico
AU  - Heffler E
AD  - Personalized Medicine, Asthma and Allergy - Humanitas Research Hospital, Rozzano, 
      Italy.
FAU - Lombardi, Carlo
AU  - Lombardi C
AD  - Departmental Unit of Pneumology & Allergology, Istituto Ospedaliero Fondazione 
      Poliambulanza, Brescia, Italy.
FAU - Menichini, Ilaria
AU  - Menichini I
AD  - Dept of Cardiovascular, Respiratory, Nephrology, Anaesthesiology and Geriatric 
      Science, "Sapienza" University, Rome, Italy.
FAU - Milanese, Manlio
AU  - Milanese M
AD  - Division of Pulmonology, S Corona Hospital, Savona, Italy.
FAU - Scichilone, Nicola
AU  - Scichilone N
AUID- ORCID: 0000-0001-6400-6573
AD  - AOUP Policlinico Universitario, DIBIMIS, Universita di Palermo, Palermo, Italy.
FAU - Senna, Gianenrico
AU  - Senna G
AD  - Dept of Medicine, University of Verona, Verona, Italy.
AD  - Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.
FAU - Canonica, Giorgio W
AU  - Canonica GW
AD  - Personalized Medicine, Asthma and Allergy - Humanitas Research Hospital, Rozzano, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200603
PL  - England
TA  - Eur Respir Rev
JT  - European respiratory review : an official journal of the European Respiratory 
      Society
JID - 9111391
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Asthma/diagnosis/*drug therapy/metabolism/physiopathology
MH  - Biomarkers/metabolism
MH  - Bronchoconstriction/*drug effects
MH  - Consensus
MH  - Delphi Technique
MH  - Endpoint Determination
MH  - Humans
MH  - Inflammation Mediators/*metabolism
MH  - Lung/*drug effects/metabolism/physiopathology
MH  - *Minimal Clinically Important Difference
MH  - Predictive Value of Tests
MH  - Symptom Assessment
MH  - Treatment Outcome
PMC - PMC9488652
COIS- Conflict of interest: M. Bonini has nothing to disclose. Conflict of interest: M. 
      Di Paolo has nothing to disclose. Conflict of interest: D. Bagnasco has nothing 
      to disclose. Conflict of interest: I. Baiardini has nothing to disclose. Conflict 
      of interest: F. Braido has nothing to disclose. Conflict of interest: M. Caminati 
      has nothing to disclose. Conflict of interest: E. Carpagnano has nothing to 
      disclose. Conflict of interest: M. Contoli reports grants from Chiesi, personal 
      fees from Chiesi, AstraZeneca, Boehringer Ingelheim, Novartis Menarini, 
      Mundipharma, Almirall and Zambon, and grants from University of Ferrara (Italy), 
      outside the submitted work. Conflict of interest: A. Corsico has nothing to 
      disclose. Conflict of interest: S. Del Giacco has nothing to disclose. Conflict 
      of interest: E. Heffler has nothing to disclose. Conflict of interest: C. 
      Lombardi has nothing to disclose. Conflict of interest: I. Menichini has nothing 
      to disclose. Conflict of interest: M. Milanese has nothing to disclose. Conflict 
      of interest: N. Scichilone has nothing to disclose. Conflict of interest: G. 
      Senna has nothing to disclose. Conflict of interest: G.W. Canonica has nothing to 
      disclose.
EDAT- 2020/06/06 06:00
MHDA- 2021/04/07 06:00
PMCR- 2020/06/03
CRDT- 2020/06/06 06:00
PHST- 2019/10/25 00:00 [received]
PHST- 2020/03/09 00:00 [accepted]
PHST- 2020/06/06 06:00 [entrez]
PHST- 2020/06/06 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2020/06/03 00:00 [pmc-release]
AID - 29/156/190137 [pii]
AID - ERR-0137-2019 [pii]
AID - 10.1183/16000617.0137-2019 [doi]
PST - epublish
SO  - Eur Respir Rev. 2020 Jun 3;29(156):190137. doi: 10.1183/16000617.0137-2019. Print 
      2020 Jun 30.