PMID- 32501583
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1532-2149 (Electronic)
IS  - 1090-3801 (Linking)
VI  - 24
IP  - 8
DP  - 2020 Sep
TI  - Within- and between-session reliability of secondary hyperalgesia induced by 
      electrical high-frequency stimulation.
PG  - 1585-1597
LID - 10.1002/ejp.1613 [doi]
AB  - BACKGROUND: An increasing number of studies are focusing on secondary 
      hyperalgesia to better understand central sensitization, as this phenomenon may 
      play an important role in persistent pain. Recent studies have shown that, 
      compared to the classical high-frequency stimulation protocol (HFS) at 100 Hz, a 
      protocol using 42 Hz stimulation induces a more intense and a larger area of 
      secondary hyperalgesia (SH). OBJECTIVES: The aim of this study was to investigate 
      the within- and between-session reliability of SH induced by this optimized HFS 
      protocol. METHODS: Thirty-two healthy subjects received HFS to their volar 
      forearm in two sessions, separated by at least 2 weeks. SH was assessed by 
      measuring the area size of increased sensitivity to pinprick stimuli after 
      applying HFS, the sensitivity to pinprick stimuli after applying HFS and the 
      change in pinprick sensitivity after versus before HFS. Assessments were made 
      before HFS, and 30, 35 and 40 min after HFS. Relative and absolute reliability 
      were analysed using intraclass correlation coefficients (ICCs), coefficients of 
      variation (CVs), standard error of means (SEMs) and the minimum detectable 
      changes (MDCs). RESULTS: The area of SH showed good to excellent within-session 
      and between-session relative reliability (ICCs > 0.80), except for the change in 
      pinprick sensitivity, which showed close to poor between-session relative 
      reliability (ICC = 0.53). Furthermore, measures of absolute reliability generally 
      demonstrated large between-subject variability and significant fluctuations 
      across repeated measurements. CONCLUSIONS: HFS-induced hyperalgesia is suitable 
      to discriminate or compare individuals but it may not be sensitive to changes due 
      to an intervention. SIGNIFICANCE: It is crucial to evaluate central sensitization 
      adequately in humans. This study formally establishes the reliability of 
      secondary hyperalgesia induced by electrical high-frequency stimulation. The 
      results of this study will improve future studies investigating secondary 
      hyperalgesia in humans.
CI  - (c) 2020 European Pain Federation - EFIC(R).
FAU - Cayrol, Timothee
AU  - Cayrol T
AUID- ORCID: 0000-0002-1099-5545
AD  - Institute of Experimental and Clinical Research, Health Sciences Division, 
      Universite Catholique de Louvain, Neuro-Musculo-Skeletal-Lab (NMSK), Brussels, 
      Belgium.
FAU - Lebleu, Julien
AU  - Lebleu J
AUID- ORCID: 0000-0001-6737-4830
AD  - Institute of Experimental and Clinical Research, Health Sciences Division, 
      Universite Catholique de Louvain, Neuro-Musculo-Skeletal-Lab (NMSK), Brussels, 
      Belgium.
FAU - Mouraux, Andre
AU  - Mouraux A
AUID- ORCID: 0000-0003-1056-5980
AD  - Institute of Neuroscience, System and Cognition Division, Universite Catholique 
      de Louvain, Brussels, Belgium.
FAU - Roussel, Nathalie
AU  - Roussel N
AUID- ORCID: 0000-0002-7409-878X
AD  - Department of Rehabilitation Sciences and Physiotherapy (MOVANT), Faculty of 
      Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
FAU - Pitance, Laurent
AU  - Pitance L
AUID- ORCID: 0000-0002-5043-8946
AD  - Institute of Experimental and Clinical Research, Health Sciences Division, 
      Universite Catholique de Louvain, Neuro-Musculo-Skeletal-Lab (NMSK), Brussels, 
      Belgium.
FAU - van den Broeke, Emanuel N
AU  - van den Broeke EN
AUID- ORCID: 0000-0002-6668-3217
AD  - Institute of Neuroscience, System and Cognition Division, Universite Catholique 
      de Louvain, Brussels, Belgium.
LA  - eng
GR  - Universite Catholique de Bruxelles/International
GR  - Fonds de Recherche Clinique UCL/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200630
PL  - England
TA  - Eur J Pain
JT  - European journal of pain (London, England)
JID - 9801774
SB  - IM
MH  - Electric Stimulation
MH  - Humans
MH  - *Hyperalgesia/therapy
MH  - Pain
MH  - Pain Threshold
MH  - Reproducibility of Results
MH  - *Touch Perception
EDAT- 2020/06/06 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/06/06 06:00
PHST- 2020/01/07 00:00 [received]
PHST- 2020/04/27 00:00 [revised]
PHST- 2020/05/31 00:00 [accepted]
PHST- 2020/06/06 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/06/06 06:00 [entrez]
AID - 10.1002/ejp.1613 [doi]
PST - ppublish
SO  - Eur J Pain. 2020 Sep;24(8):1585-1597. doi: 10.1002/ejp.1613. Epub 2020 Jun 30.