PMID- 32502674
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20201130
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 69
DP  - 2020 Nov
TI  - A Comparison of Quality of Life in Elderly Patients with Intermittent 
      Claudication and Chronic Limb-Threatening Ischemia.
PG  - 285-291
LID - S0890-5096(20)30463-5 [pii]
LID - 10.1016/j.avsg.2020.05.048 [doi]
AB  - BACKGROUND: Intermittent claudication (IC) and chronic limb-threatening ischemia 
      (CLTI) are both associated with a decreased health status and possibly quality of 
      life (QOL). A better understanding of the differences in QOL between patients 
      with IC and CLTI could be of additional value in shared decision-making. The aim 
      of this study was to compare the QOL at baseline between patients with IC and 
      patients with CLTI. METHODS: The study population was based on 2 study cohorts, 1 
      cohort consisted of patients with IC (ELECT registry) and the other cohort of 
      patients with CLTI (KOP-study). Patients with an age of >/=70 years were included. 
      QOL at baseline was measured by the WHOQOL-BREF questionnaire. Nonresponders were 
      excluded from data analyses. Student's t-tests and analysis of covariance 
      (ANCOVA) analyses were used to compare QOL between the 2 groups. Outcomes of the 
      ANCOVA analyses were expressed as estimated marginal means. RESULTS: In total, 
      308 patients were included, 115 patients with IC and 193 patients with CLTI. 
      Patients with CLTI were older (median age 80 years vs. 75 years, P < 0.001) and 
      had more comorbidities. Patients with IC had a statistically significant higher 
      QOL regarding physical health (mean 13.7 [standard deviation (SD) 2.3] vs. 10.8 
      [SD 2.8], P < 0.001), psychological health (mean 15.3 [SD 2.1] vs. 14.1 [SD 2.4], 
      P < 0.001), environment (mean 16.3 [SD 2.4] vs. 15.5 [SD 2.0], P < 0.002), and 
      the overall domain (mean 3.5 [SD 0.7] vs. 3.1 [SD 0.9], P < 0.001). After 
      correcting for the confounding effect of age and sex, patients with IC still had 
      a statistically significant higher QOL in the physical, psychological, 
      environment, and overall domain. CONCLUSIONS: Patients with IC had a 
      significantly higher QOL in the physical, psychological, environment, and overall 
      domains of the WHOQOL-BREF questionnaire compared with patients with CLTI. This 
      underlines the importance of strategies that reduce disease progression as 
      disease progression is associated with a decrease in QOL.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Roijers, Joost P
AU  - Roijers JP
AD  - Department of Surgery, Amphia Hospital, Breda, the Netherlands. Electronic 
      address: joostroijers@hotmail.com.
FAU - van den Houten, Marijn M
AU  - van den Houten MM
AD  - Department of Vascular Surgery, Catharina Hospital, Eindhoven, the Netherlands.
FAU - Hopmans, Niels J
AU  - Hopmans NJ
AD  - Department of Surgery, Amphia Hospital, Breda, the Netherlands.
FAU - Vriens, Patrick W H E
AU  - Vriens PWHE
AD  - Dept. of Vascular Surgery, Elisabeth Twee Steden Hospital, Tilburg, the 
      Netherlands.
FAU - Willigendael, Edith M
AU  - Willigendael EM
AD  - Dept. of Vascular Surgery, Medical Spectrum Twente, Enschede, the Netherlands.
FAU - Lodder, Paul
AU  - Lodder P
AD  - Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the 
      Netherlands; Department of Methodology and Statistics, Tilburg University, 
      Tilburg, the Netherlands.
FAU - de Vries, Jolanda
AU  - de Vries J
AD  - Dept. of Vascular Surgery, Elisabeth Twee Steden Hospital, Tilburg, the 
      Netherlands.
FAU - Teijink, Joep A
AU  - Teijink JA
AD  - Department of Vascular Surgery, Catharina Hospital, Eindhoven, the Netherlands; 
      CAPHRI School for Public Health and Primary Care, Faculty of Health, Medicine and 
      Life Sciences, Maastricht University, Maastricht, the Netherlands.
FAU - van der Laan, Lijckle
AU  - van der Laan L
AD  - Department of Surgery, Amphia Hospital, Breda, the Netherlands; Department of 
      Cardiovascular Science, KU Leuven, Belgium.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200603
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Intermittent Claudication/*diagnosis/physiopathology/psychology/therapy
MH  - Ischemia/*diagnosis/physiopathology/psychology/therapy
MH  - Male
MH  - *Patient Reported Outcome Measures
MH  - Predictive Value of Tests
MH  - *Quality of Life
MH  - Registries
EDAT- 2020/06/06 06:00
MHDA- 2020/12/01 06:00
CRDT- 2020/06/06 06:00
PHST- 2020/04/11 00:00 [received]
PHST- 2020/05/13 00:00 [revised]
PHST- 2020/05/14 00:00 [accepted]
PHST- 2020/06/06 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/06/06 06:00 [entrez]
AID - S0890-5096(20)30463-5 [pii]
AID - 10.1016/j.avsg.2020.05.048 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2020 Nov;69:285-291. doi: 10.1016/j.avsg.2020.05.048. Epub 2020 
      Jun 3.