PMID- 32504203 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20200914 LR - 20200914 IS - 1436-5073 (Electronic) IS - 0026-3672 (Linking) VI - 187 IP - 7 DP - 2020 Jun 5 TI - High-throughput screening of bisphenols using magnetic covalent organic frameworks as a SELDI-TOF-MS probe. PG - 370 LID - 10.1007/s00604-020-04340-5 [doi] AB - Core-shell structured magnetic covalent organic framework (Fe(3)O(4)@COF) nanospheres were rapidly synthesized at room temperature using the monodisperse Fe(3)O(4) nanoparticles (NPs) as magnetic core and benzene-1,3,5-tricarbaldehyde (BTA) and 3,3'-dihydroxybenzidine (DHBD) as two building blocks (denoted as Fe(3)O(4)@BTA-DHBD), respectively. They can serve as a mass spectrometry probe for rapid and high-throughput screening of bisphenols (BPs) from pharmaceuticals and personal care products (PPCPs) by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). The Fe(3)O(4)@BTA-DHBD nanospheres showed some superior features involving average pore size distribution (2.82 nm), high magnetization values (42.5 emu g(-1)), high specific surface area (82.96 m(2) g(-1)), and good chemical/thermal stability. It was used as both ideal adsorbent for enrichment of BPs and new substrate to assist ionization in SELDI-TOF-MS. The method exhibited good linearity in the range 0.05-4000 ng mL(-1) with correlation coefficients (r) higher than 0.9920. Low limits of detection (LODs) (500 pg mL(-1) for bisphenol A (BPA), 2 pg mL(-1) for bisphenol B (BPB), 28 pg mL(-1) for bisphenol C (BPC), 60 pg mL(-1) for bisphenol F (BPF), 33 pg mL(-1) for bisphenol AF (BPAF), 200 pg mL(-1) for bisphenol BP (BPBP), 10 pg mL(-1) for bisphenol S (BPS), 90 pg mL(-1) for tetrabromobisphenol A (BPA(Br)(4)), and 380 pg mL(-1) for tetrabromobisphenol S (BPS(Br)(4))) and good recoveries (80.6-115%) of BPs in PPCPs were achieved. The relative standard deviations (RSDs) of spot-to-spot (n = 10) and sample-to-sample (n = 5) were in the ranges 5-11% and 5-12%, respectively. The dual-function platform was successfully applied to the quantitative determination of BPs in PPCPs. It not only expanded the scope of the application of COFs but also provided an alternative strategy for the determination of hazardous compounds in PPCPs. Graphical abstract Schematic representation of the synthesis of core-shell structured magnetic covalent organic framework nanospheres (Fe(3)O(4)@COFs) and its application in the analysis of bisphenols by using Fe(3)O(4)@BTA-DHBD nanospheres as a MS probe based on surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. FAU - Sun, Qianqian AU - Sun Q AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Gao, Chaohong AU - Gao C AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Ma, Wende AU - Ma W AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - He, Yanting AU - He Y AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Wu, Jie AU - Wu J AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Luo, Kailong AU - Luo K AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Ouyang, Dan AU - Ouyang D AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Lin, Zian AU - Lin Z AUID- ORCID: 0000-0002-0866-0711 AD - Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. zianlin@fzu.edu.cn. FAU - Cai, Zongwei AU - Cai Z AUID- ORCID: 0000-0002-8724-7684 AD - State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, 999077, Hong Kong SAR, China. zwcai@hkbu.edu.hk. LA - eng GR - 21675025, 21974021 and 91843301/National Natural Science Foundation of China/International GR - 2018J01683/Natural Science Foundation of Fujian Province/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200605 PL - Austria TA - Mikrochim Acta JT - Mikrochimica acta JID - 7808782 SB - IM OTO - NOTNLM OT - Adsorbent OT - BPs OT - Dual-function platform OT - Enrichment OT - Fe3O4@BTA-DHBD OT - Ionization OT - MS probe OT - Pharmaceuticals and personal care products OT - Substrate EDAT- 2020/06/07 06:00 MHDA- 2020/06/07 06:01 CRDT- 2020/06/07 06:00 PHST- 2019/10/17 00:00 [received] PHST- 2020/05/18 00:00 [accepted] PHST- 2020/06/07 06:00 [entrez] PHST- 2020/06/07 06:00 [pubmed] PHST- 2020/06/07 06:01 [medline] AID - 10.1007/s00604-020-04340-5 [pii] AID - 10.1007/s00604-020-04340-5 [doi] PST - epublish SO - Mikrochim Acta. 2020 Jun 5;187(7):370. doi: 10.1007/s00604-020-04340-5.