PMID- 32504847
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 188
DP  - 2020 Sep
TI  - Hyperactivity disorder in children related to traffic-based air pollution during 
      pregnancy.
PG  - 109588
LID - S0013-9351(20)30481-3 [pii]
LID - 10.1016/j.envres.2020.109588 [doi]
AB  - BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is one of the most 
      common neurobehavioral disorders in childhood globally. Between the two 
      components of ADHD, hyperactivity disorder is more prevalent than inattention 
      during early childhood. Although some investigations have implied a relationship 
      between childhood ADHD and gestational exposure to air pollution, the evidence is 
      limited. The aim of this study was to investigate the association between 
      gestational exposure to air pollution exposure and hyperactivity disorder in 
      childhood in a population-based birth cohort. METHODS: The Taiwan Birth Cohort 
      Study started from all deliveries of Taiwan in 2005 by the birth registry, and 
      recruited representative 12% of all mother-infant pairs by two-stage stratified 
      sampling. At age of 8 years in each child, their main caretaker was inquired 
      whether the child had ever received a hyperactivity diagnosis from a physician or 
      other specialist, like special needs educator. Exposure to air pollutants during 
      gestation was estimated through ordinary kriging based on data from air 
      monitoring stations of Environmental Protection Administration, Taiwan. Logistic 
      regression was used to determine adjusted odds ratios (aORs) of hyperactivity 
      disorder in relation to air pollutants. RESULTS: A total of 16,376 mother-infant 
      pairs were included in the final analysis; 374 (2.3%) of the children had 
      received a diagnosis of hyperactivity before 8 years of age. The occurrence of 
      hyperactivity was significantly related to prenatal nitrogen oxide (NO(x)), but 
      not to particulate matter 10 mum or less in diameter or sulfur dioxide. Further 
      analysis to separate effects by nitrogen dioxide (NO(2)) and/or nitric oxide (NO) 
      showed that only NO was significantly related to hyperactivity [aOR per 
      interquartile range (3.14 ppb): 1.26, 95% confidence interval: 1.09-1.46]. 
      CONCLUSIONS: In conclusion, our study found childhood hyperactivity disorder to 
      be positively associated with prenatal NO exposure. Further confirmation on 
      potential hazardous effects of NO and investigation on potential mechanisms are 
      warranted.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Shih, Ping
AU  - Shih P
AD  - Department of Environmental and Occupational Medicine, National Taiwan University 
      Hospital, Taipei, Taiwan; Institute of Environmental and Occupational Health 
      Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan.
FAU - Huang, Ching-Chun
AU  - Huang CC
AD  - Department of Environmental and Occupational Medicine, National Taiwan University 
      Hospital, Taipei, Taiwan; Department of Environmental and Occupational Medicine, 
      College of Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Pan, Shih-Chun
AU  - Pan SC
AD  - National Institute of Environmental Health Sciences, National Health Research 
      Institutes, Miaoli, Taiwan.
FAU - Chiang, Tung-Liang
AU  - Chiang TL
AD  - Institute of Health Policy and Management, College of Public Health, National 
      Taiwan University, Taipei, Taiwan.
FAU - Guo, Yue Leon
AU  - Guo YL
AD  - Department of Environmental and Occupational Medicine, National Taiwan University 
      Hospital, Taipei, Taiwan; Institute of Environmental and Occupational Health 
      Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan; 
      National Institute of Environmental Health Sciences, National Health Research 
      Institutes, Miaoli, Taiwan; Department of Environmental and Occupational 
      Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. 
      Electronic address: leonguo@ntu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200425
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - *Air Pollutants/analysis/toxicity
MH  - *Air Pollution/adverse effects/analysis
MH  - *Attention Deficit Disorder with Hyperactivity/chemically induced/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Environmental Exposure/analysis
MH  - Female
MH  - Humans
MH  - Infant
MH  - Nitrogen Dioxide/analysis/toxicity
MH  - Particulate Matter/analysis
MH  - Pregnancy
MH  - Taiwan/epidemiology
OTO - NOTNLM
OT  - Cohort study
OT  - Hyperactivity
OT  - Nitric oxide
OT  - Pregnancy
OT  - Traffic-related air pollution
EDAT- 2020/06/07 06:00
MHDA- 2020/11/21 06:00
CRDT- 2020/06/07 06:00
PHST- 2019/12/02 00:00 [received]
PHST- 2020/03/31 00:00 [revised]
PHST- 2020/04/23 00:00 [accepted]
PHST- 2020/06/07 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/06/07 06:00 [entrez]
AID - S0013-9351(20)30481-3 [pii]
AID - 10.1016/j.envres.2020.109588 [doi]
PST - ppublish
SO  - Environ Res. 2020 Sep;188:109588. doi: 10.1016/j.envres.2020.109588. Epub 2020 
      Apr 25.