PMID- 32504881 OWN - NLM STAT- MEDLINE DCOM- 20210929 LR - 20240329 IS - 1872-6232 (Electronic) IS - 0378-3782 (Print) IS - 0378-3782 (Linking) VI - 147 DP - 2020 Aug TI - Early working memory is a significant predictor of verbal and processing skills at 6-7 years in children born extremely preterm. PG - 105083 LID - S0378-3782(20)30030-X [pii] LID - 10.1016/j.earlhumdev.2020.105083 [doi] AB - OBJECTIVE: The study was designed to investigate whether attainment of object permanence, a measure of early working memory used at 18-22 months corrected age, was associated with executive function at 6-7 years in a cohort of children born extremely preterm. STUDY DESIGN: Children enrolled in the Neuroimaging and Neurodevelopmental Outcome (NEURO) study, a secondary study to the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) of the NICHD NRN, were eligible for this longitudinal study. Testing completed at 18 to 22 months corrected age was compared to testing at school age with a specific focus on measures of executive function. RESULTS: Children who had achieved object permanence mastery at a corrected age of 18-22 months had higher mean scores on the WISC-IV tests of verbal comprehension and processing speed at age 6-7 years. Regression models indicated that object permanence scores were significant predictors of both verbal comprehension and processing speeds scores, after controlling for other factors. When analyzed by subgroup for sex, these results were significant for girls but not for boys. CONCLUSIONS: This study found that an early mastery of object permanence was associated with higher scores in areas of verbal comprehension and processing speed in girls. These results have implications for potentially identifying young children born preterm that are at greater risk for difficulties with cognitive and working memory skills at school age. CI - Copyright (c) 2020 Elsevier B.V. All rights reserved. FAU - Lowe, Jean AU - Lowe J AD - University of New Mexico Health Sciences Center, Albuquerque, NM, USA. FAU - Bann, Carla M AU - Bann CM AD - Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC, USA. FAU - Fuller, Janell AU - Fuller J AD - University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address: jafuller@salud.unm.edu. FAU - Vohr, Betty R AU - Vohr BR AD - Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA. FAU - Hintz, Susan R AU - Hintz SR AD - Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA. FAU - Das, Abhik AU - Das A AD - Social, Statistical and Environmental Sciences Unit, RTI International, Bethesda, MD, USA. FAU - Higgins, Rosemary D AU - Higgins RD AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. FAU - Watterberg, Kristi L AU - Watterberg KL AD - University of New Mexico Health Sciences Center, Albuquerque, NM, USA. CN - SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network LA - eng GR - U10 HD021385/HD/NICHD NIH HHS/United States GR - U10 HD053124/HD/NICHD NIH HHS/United States GR - U10 HD053119/HD/NICHD NIH HHS/United States GR - U10 HD021364/HD/NICHD NIH HHS/United States GR - UG1 HD053089/HD/NICHD NIH HHS/United States GR - U10 HD040461/HD/NICHD NIH HHS/United States GR - U10 HD027904/HD/NICHD NIH HHS/United States GR - U10 HD027851/HD/NICHD NIH HHS/United States GR - UL1 RR025008/RR/NCRR NIH HHS/United States GR - U24 HD095254/HD/NICHD NIH HHS/United States GR - U10 HD027856/HD/NICHD NIH HHS/United States GR - U10 HD021373/HD/NICHD NIH HHS/United States GR - U10 HD027880/HD/NICHD NIH HHS/United States GR - UG1 HD027853/HD/NICHD NIH HHS/United States GR - U10 HD053109/HD/NICHD NIH HHS/United States GR - U10 HD040689/HD/NICHD NIH HHS/United States GR - U10 HD040492/HD/NICHD NIH HHS/United States GR - UG1 HD027904/HD/NICHD NIH HHS/United States GR - UL1 RR025744/RR/NCRR NIH HHS/United States GR - U10 HD034216/HD/NICHD NIH HHS/United States GR - U10 HD036790/HD/NICHD NIH HHS/United States GR - U10 HD053089/HD/NICHD NIH HHS/United States GR - UL1 TR003142/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20200523 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Child MH - Executive Function MH - Female MH - Humans MH - Infant, Extremely Premature/*growth & development/psychology MH - Infant, Newborn MH - *Language Development MH - Male MH - *Memory, Short-Term PMC - PMC7384388 MID - NIHMS1602647 OTO - NOTNLM OT - Development OT - Executive function OT - Extremely low birth weight COIS- Declaration of competing interest The authors have no conflicts of interest to disclose. EDAT- 2020/06/07 06:00 MHDA- 2021/09/30 06:00 PMCR- 2021/08/01 CRDT- 2020/06/07 06:00 PHST- 2020/01/24 00:00 [received] PHST- 2020/04/22 00:00 [revised] PHST- 2020/05/20 00:00 [accepted] PHST- 2020/06/07 06:00 [pubmed] PHST- 2021/09/30 06:00 [medline] PHST- 2020/06/07 06:00 [entrez] PHST- 2021/08/01 00:00 [pmc-release] AID - S0378-3782(20)30030-X [pii] AID - 10.1016/j.earlhumdev.2020.105083 [doi] PST - ppublish SO - Early Hum Dev. 2020 Aug;147:105083. doi: 10.1016/j.earlhumdev.2020.105083. Epub 2020 May 23.