PMID- 32505773
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 509
DP  - 2020 Oct
TI  - Serum biomarkers that predict lean mass loss over bed rest in older adults: An 
      exploratory study.
PG  - 72-78
LID - S0009-8981(20)30267-9 [pii]
LID - 10.1016/j.cca.2020.06.003 [doi]
AB  - BACKGROUND: Lean mass (LM) loss during extended bed rest contributes to long term 
      functional decline in older adults. Identifying blood biomarkers that predict a 
      hospitalized individual's risk of losing LM could allow for timely intervention. 
      METHODS: LM from 19 healthy subjects (age 60-76 y, 4 males, 15 females), who were 
      confined to 10 days of complete bed rest, was measured pre- and post-bed rest. 
      One hundred eighty-seven biomarkers from pre-bed rest fasted serum samples were 
      obtained from all evaluable subjects (n = 18), analyzed using multiplexed 
      immunoassay array and pooled. Decision tree analysis was used to identify pre-bed 
      rest markers that predict LM loss over bed rest. RESULTS: Sixty-three markers 
      were excluded due to being below assay detection limits. One pair of markers, 
      Tissue inhibitor of metalloprotease-1 (TIMP1) and tenascin C (TNC), were found to 
      correlate with percent change in total LM over bed rest: [R(2) = 0.71, all 
      subjects; R(2) = 0.76, females]. Subjects with pre-bed rest TIMP1 >/= 141 ng/ml had 
      the highest loss of total LM over bed rest, whereas subjects with pre-bed rest 
      TIMP1 < 141 and TNC >/= 461 ng/ml maintained total LM over bed rest. An additional 
      marker set was found to correlate with percent change in leg LM loss over bed 
      rest: matrix metalloprotease-3 (MMP3) and apolipoprotein A2 (APOA2) [R(2) = 0.59, 
      females]. Females with pre-bed rest MMP3 < 6.93 ng/ml had the highest loss of leg 
      LM over bed rest. Whereas females with pre-bed rest MMP3 >/= 6.93 and 
      ApoA2 < 276 ng/ml, maintained leg lean mass at the end of bed rest. CONCLUSIONS: 
      Panels of blood biomarkers associated with the muscle extracellular matrix may 
      predict the likelihood for LM loss over extended bed rest.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Gawel, Susan H
AU  - Gawel SH
AD  - Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott 
      Park, IL 60064, USA.
FAU - Davis, Gerard J
AU  - Davis GJ
AD  - Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott 
      Park, IL 60064, USA.
FAU - Luo, Menghua
AU  - Luo M
AD  - Abbott Nutrition Division, Abbott Laboratories, 3300 Stelzer Road, Columbus, OH 
      43219, USA.
FAU - Deutz, Nicolaas E P
AU  - Deutz NEP
AD  - Texas A&M University, Department of Health & Kinesiology, 675 John Kimbrough 
      Blvd, College Station, TX 77843-4253, USA.
FAU - Wolfe, Robert R
AU  - Wolfe RR
AD  - University of Arkansas Medical Sciences, UAMS Centers on Aging, 4301 West Markham 
      Street, Little Rock, AR 72205, USA.
FAU - Pereira, Suzette L
AU  - Pereira SL
AD  - Abbott Nutrition Division, Abbott Laboratories, 3300 Stelzer Road, Columbus, OH 
      43219, USA. Electronic address: suzette.pereira@abbott.com.
LA  - eng
PT  - Journal Article
DEP - 20200604
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - *Bed Rest
MH  - Biomarkers
MH  - Body Composition
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Muscle, Skeletal
OTO - NOTNLM
OT  - Bed rest
OT  - Biomarkers
OT  - DEXA
OT  - Hospitalization
OT  - Immobilization
OT  - Lean mass
EDAT- 2020/06/09 06:00
MHDA- 2021/05/26 06:00
CRDT- 2020/06/08 06:00
PHST- 2020/04/01 00:00 [received]
PHST- 2020/05/23 00:00 [revised]
PHST- 2020/06/02 00:00 [accepted]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/06/08 06:00 [entrez]
AID - S0009-8981(20)30267-9 [pii]
AID - 10.1016/j.cca.2020.06.003 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2020 Oct;509:72-78. doi: 10.1016/j.cca.2020.06.003. Epub 2020 Jun 
      4.