PMID- 32506181
OWN - NLM
STAT- MEDLINE
DCOM- 20210208
LR  - 20210607
IS  - 1534-6315 (Electronic)
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 20
IP  - 8
DP  - 2020 Jun 6
TI  - Eosinophilic Esophagitis: Existing and Upcoming Therapies in an Age of Emerging 
      Molecular and Personalized Medicine.
PG  - 30
LID - 10.1007/s11882-020-00928-2 [doi]
AB  - PURPOSE OF REVIEW: Recent research efforts have spurred great progress in the 
      diagnosis and management of eosinophilic esophagitis (EoE). Nonetheless, 
      challenges remain in addressing disease burden and impairment in the growing EoE 
      population. We highlight work from the Cincinnati Center for Eosinophilic 
      Disorders, the Consortium of Eosinophilic Gastrointestinal Disease Researchers, 
      and others that address these ongoing challenges. RECENT FINDINGS: New tools for 
      characterizing EoE disease activity include the EoE Histology Scoring System 
      (EoEHSS), endoscopic alternatives, validated patient-reported outcome (PRO) 
      questionnaires, and investigational biomarkers. These diagnostic and monitoring 
      strategies have been complemented by advances in EoE therapy. Treatment 
      modalities have refined the traditional approaches of dietary elimination, 
      swallowed steroids, and proton pump inhibitors (PPI), and biologics offer promise 
      for future treatment. This review summarizes EoE advances in disease management 
      and newly defined EoE endotypes that may serve as the foundation for 
      EoE-personalized medicine.
FAU - Slack, Ian F
AU  - Slack IF
AD  - Division of Allergy and Immunology, Department of Pediatrics, University of 
      Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 
      3333 Burnet Avenue, MLC 7028, Cincinnati, OH, 45229, USA.
FAU - Schwartz, Justin T
AU  - Schwartz JT
AD  - Division of Allergy and Immunology, Department of Pediatrics, University of 
      Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 
      3333 Burnet Avenue, MLC 7028, Cincinnati, OH, 45229, USA.
FAU - Mukkada, Vincent A
AU  - Mukkada VA
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 
      University of Cincinnati College of Medicine, Cincinnati Children's Hospital 
      Medical Center, Cincinnati, OH, USA.
FAU - Hottinger, Shawna
AU  - Hottinger S
AD  - Division of Allergy and Immunology, Department of Pediatrics, University of 
      Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 
      3333 Burnet Avenue, MLC 7028, Cincinnati, OH, 45229, USA.
FAU - Abonia, J Pablo
AU  - Abonia JP
AD  - Division of Allergy and Immunology, Department of Pediatrics, University of 
      Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 
      3333 Burnet Avenue, MLC 7028, Cincinnati, OH, 45229, USA. Pablo.Abonia@cchmc.org.
LA  - eng
GR  - U54 AI117804/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20200606
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
SB  - IM
MH  - Eosinophilic Esophagitis/diagnosis/*therapy
MH  - Humans
MH  - Precision Medicine/*methods
PMC - PMC8034809
MID - NIHMS1685915
OTO - NOTNLM
OT  - Diagnosis
OT  - Endotype
OT  - Eosinophilic esophagitis
OT  - Treatment
COIS- Conflict of Interest Mrs. Hottinger reports grants from the Consortium of 
      Eosinophilic Gastrointestinal Disease Researchers (CEGIR; Administrative Core, 
      U54AI117804), outside the submitted work. Dr. Mukkada reports consulting fees 
      from Shire/Takeda, outside the submitted work. The other authors declare no 
      conflicts of interest relevant to this manuscript.
EDAT- 2020/06/09 06:00
MHDA- 2021/02/09 06:00
PMCR- 2021/06/06
CRDT- 2020/06/08 06:00
PHST- 2020/06/08 06:00 [entrez]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2021/02/09 06:00 [medline]
PHST- 2021/06/06 00:00 [pmc-release]
AID - 10.1007/s11882-020-00928-2 [pii]
AID - 10.1007/s11882-020-00928-2 [doi]
PST - epublish
SO  - Curr Allergy Asthma Rep. 2020 Jun 6;20(8):30. doi: 10.1007/s11882-020-00928-2.