PMID- 32506479
OWN - NLM
STAT- MEDLINE
DCOM- 20210824
LR  - 20210824
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Linking)
VI  - 98
IP  - 8
DP  - 2020 Sep
TI  - CXCL8(high) inflammatory B cells in the peripheral blood of patients with biliary 
      atresia are involved in disease progression.
PG  - 682-692
LID - 10.1111/imcb.12366 [doi]
AB  - Biliary atresia (BA), the most common cause of pediatric end-stage liver disease, 
      results from fibroinflammatory obstruction of the intrahepatic and extrahepatic 
      bile ducts. The etiology of BA has been extensively studied, and inflammation and 
      imbalanced immune system have been identified as the main pathogenesis of BA. B 
      cells play roles in innate and adaptive immunity, but few studies have 
      investigated the role of B cells in BA. This study aimed to elucidate the role of 
      B cells in the development of BA. The percentage and numbers of total B cells 
      (23.81 +/- 11.14%，P < 0.0001, 1.22 +/- 0.67 x 10(9) L(-1) , P = 0.0014) and immature 
      B cells (25.33 +/- 14.32%, P = 0.0013, 0.19 +/- 0.20 x 10(9) L(-1) , P < 0.0001) were 
      significantly increased in the peripheral blood of patients with BA and the 
      number of total B cells was positively correlated with 
      gamma-glutamyl-transpeptidase in the serum of BA. High C-X-C motif chemokine 
      ligand 8 (CXCL8) levels were detected in the serum of patients with BA. As an 
      important source of CXCL8, B cells from patients with BA secreted more CXCL8 into 
      peripheral blood than those from control patients. Moreover, immature B cells can 
      secrete more CXCL8 than mature B cells, and B cells secreted CXCL8 upon 
      activation of the nuclear factor-kappaB pathway. Taken together, the results revealed 
      that B cells have a strong ability to secrete CXCL8, which is associated with the 
      pathogenesis of BA, and exert a proinflammatory effect on the development of BA.
CI  - (c) 2020 Australian and New Zealand Society for Immunology Inc.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Zhou, Lin
AU  - Zhou L
AD  - Shanghai Institute of Immunology, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Gu, Guangxiang
AU  - Gu G
AD  - Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Feng, Mingxuan
AU  - Feng M
AD  - Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Ding, Xuping
AU  - Ding X
AD  - Shanghai Institute of Immunology, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Xia, Qiang
AU  - Xia Q
AD  - Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Lu, Liming
AU  - Lu L
AD  - Shanghai Institute of Immunology, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200913
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - B-Lymphocytes/*immunology
MH  - *Biliary Atresia/immunology
MH  - Child
MH  - Disease Progression
MH  - End Stage Liver Disease
MH  - Humans
MH  - Interleukin-8/*blood
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - B cell
OT  - Biliary atresia
OT  - CXCL8
EDAT- 2020/06/09 06:00
MHDA- 2021/08/25 06:00
CRDT- 2020/06/08 06:00
PHST- 2020/02/03 00:00 [received]
PHST- 2020/05/25 00:00 [revised]
PHST- 2020/06/02 00:00 [accepted]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2021/08/25 06:00 [medline]
PHST- 2020/06/08 06:00 [entrez]
AID - 10.1111/imcb.12366 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2020 Sep;98(8):682-692. doi: 10.1111/imcb.12366. Epub 2020 Sep 
      13.