PMID- 32507344
OWN - NLM
STAT- MEDLINE
DCOM- 20210216
LR  - 20210216
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 120
IP  - 1 Pt 1
DP  - 2021 Jan
TI  - Impact of inhaled corticosteroids on the neurodevelopmental outcomes in 
      chronically ventilated extremely low birth weight preterm infants.
PG  - 275-280
LID - S0929-6646(20)30205-9 [pii]
LID - 10.1016/j.jfma.2020.05.015 [doi]
AB  - BACKGROUND: Few studies have assessed the long-term impact of inhaled 
      corticosteroids (ICS) in preterm infants. This study evaluated the 
      neurodevelopmental outcomes of chronically ventilated extremely low birth weight 
      (ELBW) preterm infants exposed to ICS. METHODS: The medical records of ELBW 
      preterm infants admitted to two tertiary-level neonatal intensive care units from 
      2008 to 2014 were reviewed. Infants intubated for more than 28 days were 
      included. The neurodevelopmental outcomes were compared at 24 months corrected 
      age, between those with ICS exposure (inhaled group, IH) and those without it 
      (non-inhaled group, NIH), by using the Bayley-Scale-of-Infant-and-Toddler 
      Development-III (BSID-III). RESULTS: Out of the 115 infants included, 64 had an 
      ICS exposure. The incidence of the morbidities at the time of discharge, was 
      comparable between the two groups, except for the duration of oxygen and 
      mechanical ventilation dependence (IH 124.8 +/- 40.3 days vs. NIH: 101.0 +/- 28.6 
      days, p < 0.001 and IH 60.0 +/- 25.8 days vs. NIH: 42.3 +/- 14.2 days, p < 0.001, 
      respectively). Multiple logistic regression analysis at 24 months corrected age 
      revealed no significant differences in the BSID-III scores and in the incidence 
      of cerebral palsy and neurodevelopmental impairment. CONCLUSION: The late ICS 
      exposure was not associated with neurodevelopmental impairment at 24 months 
      corrected age in chronically ventilated ELBW infants; however, it did not reduce 
      the duration of their dependence on oxygen and mechanical ventilation.
CI  - Copyright (c) 2020 Formosan Medical Association. Published by Elsevier B.V. All 
      rights reserved.
FAU - Tiong, Ngiik-Ping
AU  - Tiong NP
AD  - Department of Neonatology, MacKay Children's Hospital, Taipei City, Taiwan.
FAU - Peng, Chun-Chih
AU  - Peng CC
AD  - Department of Neonatology, MacKay Children's Hospital, Taipei City, Taiwan; 
      Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
FAU - Hsin-Ju Ko, Mary
AU  - Hsin-Ju Ko M
AD  - Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan.
FAU - Tseng, Kai-Ti
AU  - Tseng KT
AD  - Department of Neonatology, MacKay Children's Hospital, Taipei City, Taiwan.
FAU - Chang, Jui-Hsing
AU  - Chang JH
AD  - Department of Neonatology, MacKay Children's Hospital, Taipei City, Taiwan; 
      Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
FAU - Hsu, Chyong-Hsin
AU  - Hsu CH
AD  - Department of Neonatology, MacKay Children's Hospital, Taipei City, Taiwan.
FAU - Sung, Yi-Hsiang
AU  - Sung YH
AD  - Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan.
FAU - Chang, Hung-Yang
AU  - Chang HY
AD  - Department of Neonatology, MacKay Children's Hospital, Taipei City, Taiwan; 
      Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; 
      Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan. 
      Electronic address: drhychang@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200603
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Adrenal Cortex Hormones/adverse effects
MH  - Glucocorticoids
MH  - Humans
MH  - Infant
MH  - *Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal
OTO - NOTNLM
OT  - Extremely low birth weight infants
OT  - Inhaled corticosteroid
OT  - Neurodevelopment impairment
COIS- Declaration of Competing Interest The authors have no conflicts of interest 
      relevant to this article.
EDAT- 2020/06/09 06:00
MHDA- 2021/02/17 06:00
CRDT- 2020/06/09 06:00
PHST- 2020/01/05 00:00 [received]
PHST- 2020/05/13 00:00 [revised]
PHST- 2020/05/14 00:00 [accepted]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2021/02/17 06:00 [medline]
PHST- 2020/06/09 06:00 [entrez]
AID - S0929-6646(20)30205-9 [pii]
AID - 10.1016/j.jfma.2020.05.015 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2021 Jan;120(1 Pt 1):275-280. doi: 
      10.1016/j.jfma.2020.05.015. Epub 2020 Jun 3.