PMID- 32508996
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jul
TI  - Acquired angioedema induced by angiotensin-converting enzyme inhibitors - 
      experience of a hospital-based allergy center.
PG  - 68-72
LID - 10.3892/etm.2020.8474 [doi]
AB  - Angiotensin-converting enzyme inhibitors (ACEIs) represent an important group of 
      pharmacological compounds, largely prescribed for more than 30 years. They have 
      been extensively evaluated in clinical trials, demonstrating significant 
      reduction of morbidity and mortality of patients with cardiovascular diseases, 
      mainly high blood pressure, myocardial infarction, heart failure and stroke. 
      Besides their beneficial effects and a general good safety profile, it was proven 
      that ACEIs might also induce adverse effects in some patients, most notably 
      angioedema (AE) and chronic cough. The occurrence rate of adverse events induced 
      by ACEIs is low, but the number of suffering patients is relatively high, since 
      ACEIs is one of the most frequently prescribed medication worldwide. The aim of 
      our study was to evaluate clinical pattern, risk factors and general management 
      of ACEI-induced angioedema in a cohort of patients addressed for allergist 
      evaluation in one university hospital in Romania, during a period of 32 months. 
      It was found that ACEI-induced angioedema (ACEI-AE) represented more than half of 
      the total number of patients addressed for angioedema without urticaria, with 
      variable clinical and time-patterns. Most of the patients were referred by 
      general practitioners (GPs) with diagnosis of urticaria or other skin allergy and 
      continued to take ACEIs for months and years after onset of angioedema. We 
      concluded that the awareness of acquired, non-allergic angioedema induced by ACEI 
      therapy in medical practice is still low and there is a need for improved 
      knowledge and interdisciplinary collaboration in this field.
CI  - Copyright (c) 2020, Spandidos Publications.
FAU - Mihaela Leru, Polliana
AU  - Mihaela Leru P
AD  - Family Medicine Department, 'Carol Davila' University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
AD  - Internal Medicine Department, Colentina Clinical Hospital, 020125 Bucharest, 
      Romania.
FAU - Florin Anton, Vlad
AU  - Florin Anton V
AD  - Internal Medicine Department, Colentina Clinical Hospital, 020125 Bucharest, 
      Romania.
FAU - Bocsan, Corina
AU  - Bocsan C
AD  - Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu 
      Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
FAU - Muntean, Adriana
AU  - Muntean A
AD  - Department of Immunology and Allergology, 'Iuliu Hatieganu' University of 
      Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
AD  - Allergy Department, 'Professor Doctor Octavian Fodor' Regional Institute of 
      Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania.
FAU - Boda, Daniel
AU  - Boda D
AD  - Dermatology Research Laboratory, 'Carol Davila' University of Medicine and 
      Pharmacy, 050474 Bucharest, Romania.
AD  - Dermatology Department, 'Prof. N. Paulescu' National Institute of Diabetes, 
      Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.
LA  - eng
PT  - Journal Article
DEP - 20200127
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC7271703
OTO - NOTNLM
OT  - acquired angioedema
OT  - allergy center
OT  - angiotensin-converting enzyme inhibitors
OT  - safety profile
EDAT- 2020/06/09 06:00
MHDA- 2020/06/09 06:01
PMCR- 2020/01/27
CRDT- 2020/06/09 06:00
PHST- 2019/12/06 00:00 [received]
PHST- 2020/01/17 00:00 [accepted]
PHST- 2020/06/09 06:00 [entrez]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2020/06/09 06:01 [medline]
PHST- 2020/01/27 00:00 [pmc-release]
AID - ETM-0-0-8474 [pii]
AID - 10.3892/etm.2020.8474 [doi]
PST - ppublish
SO  - Exp Ther Med. 2020 Jul;20(1):68-72. doi: 10.3892/etm.2020.8474. Epub 2020 Jan 27.