PMID- 32509385
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 10
IP  - 5
DP  - 2020
TI  - Overexpression of COX7RP promotes tumor growth and metastasis by inducing ROS 
      production in hepatocellular carcinoma cells.
PG  - 1366-1383
AB  - Cumulative evidence has indicated that mitochondrial respiration dysfunction 
      plays important roles in tumorigenesis. However, the role of COX7RP, a critical 
      regulator in the formation of mitochondrial respiratory supercomplex that has 
      been suggested to be over-expressed in hepatocellular carcinoma (HCC) by our 
      bioinformatic analysis of TCGA data, in tumor progression remains largely 
      unclear. In this study, we found that COX7RP is frequently over-expressed in HCC 
      mainly due to the down-regulation of miR-130a-3p and predicts poor prognosis of 
      HCC patients. Functional experiments revealed that COX7RP promoted both growth 
      and metastasis of HCC through induction of cell cycle progression and epithelial 
      to mesenchymal transition (EMT), and suppression of cell apoptosis. 
      Mechanistically, increased generation of reactive oxygen species (ROS) and 
      subsequently activated nuclear transcription factor-kappaB (NF-kappaB) signaling was 
      found to contribute to the promotion of HCC cell growth and metastasis by COX7RP. 
      Collectively, COX7RP plays a critical oncogenic role in hepatocellular 
      carcinogenesis, supporting COX7RP as a novel prognostic factor and therapeutic 
      target in HCC.
CI  - AJCR Copyright (c) 2020.
FAU - Wang, Guihu
AU  - Wang G
AD  - National-Local Joint Engineering Research Center of Biodiagnostics and 
      Biotherapy, Second Affiliated Hospital, Xi'an Jiaotong University Xi'an, Shaanxi, 
      People's Republic of China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong 
      University, Ministry of Education of China Xi'an, Shaanxi, People's Republic of 
      China.
FAU - Popovic, Branimir
AU  - Popovic B
AD  - The Department of Pathology, University of Pittsburgh School of Medicine 
      Pittsburgh, Pennsylvania, USA.
AD  - The Pittsburgh Liver Research Center, University of Pittsburgh and University of 
      Pittsburgh Medical Center Pittsburgh, Pennsylvania, USA.
FAU - Tao, Junyan
AU  - Tao J
AD  - The Department of Pathology, University of Pittsburgh School of Medicine 
      Pittsburgh, Pennsylvania, USA.
AD  - The Pittsburgh Liver Research Center, University of Pittsburgh and University of 
      Pittsburgh Medical Center Pittsburgh, Pennsylvania, USA.
FAU - Jiang, An
AU  - Jiang A
AD  - National-Local Joint Engineering Research Center of Biodiagnostics and 
      Biotherapy, Second Affiliated Hospital, Xi'an Jiaotong University Xi'an, Shaanxi, 
      People's Republic of China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong 
      University, Ministry of Education of China Xi'an, Shaanxi, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200501
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC7269779
OTO - NOTNLM
OT  - COX7A2L
OT  - HCC
OT  - growth
OT  - metastasis
OT  - reactive oxygen species
COIS- None.
EDAT- 2020/06/09 06:00
MHDA- 2020/06/09 06:01
PMCR- 2020/05/01
CRDT- 2020/06/09 06:00
PHST- 2019/12/14 00:00 [received]
PHST- 2020/02/02 00:00 [accepted]
PHST- 2020/06/09 06:00 [entrez]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2020/06/09 06:01 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2020 May 1;10(5):1366-1383. eCollection 2020.