PMID- 32509588
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 10
DP  - 2020
TI  - Deep Penetrating Nevus and Borderline-Deep Penetrating Nevus: A Literature 
      Review.
PG  - 837
LID - 10.3389/fonc.2020.00837 [doi]
LID - 837
AB  - Deep penetrating nevi (DPN) are rare melanocytic nevi, which can exhibit atypical 
      histological features hampering the differentiation from malignant melanoma. DPN 
      are considered benign melanocytic lesions, but rare spread to lymph nodes and 
      unfavorable clinical outcomes associated with borderline/atypical DPN (B-DPN) has 
      been reported. Since no guidelines are available for DPN and B-DPN, we aimed to 
      review the literature on DPN and B-DPN to assess the management and prognosis. We 
      screened 3,513 references from EMBASE, Scopus and Medline databases, and included 
      15 studies with a total of 355 DPN patients and 48 B-DPN patients. Therapeutic 
      interventions ranged from simple excision to wide excisions and sentinel lymph 
      node biopsy (SLNB), with block lymph node dissection in some positive SLNB cases. 
      Follow-up periods ranged from 3 months to 23 years during which a total of five 
      recurrences, two in DPN and three in B-DPN group, and three metastases, in B-DPN 
      group, were reported. While some of the included studies comprised clinical and 
      histopathological correlation, few included genetic assessment. The present 
      review highlights the need for prospective cohort studies applying composite 
      measures to identify effective regimens of diagnostic workup and treatment in DPN 
      and B-DPN.
CI  - Copyright (c) 2020 Cosgarea, Griewank, Ungureanu, Tamayo and Siepmann.
FAU - Cosgarea, Ioana
AU  - Cosgarea I
AD  - Department of Dermatology, Translational and Clinical Research Institute, 
      Newcastle University, Newcastle upon Tyne, United Kingdom.
AD  - Division of Health Care Sciences, Center for Clinical Research and Management 
      Education, Dresden International University, Dresden, Germany.
FAU - Griewank, Klaus G
AU  - Griewank KG
AD  - Department of Dermatology, University Hospital Essen, West German Cancer Center, 
      University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, 
      Germany.
AD  - Dermatopathologie bei Mainz, Nieder-Olm, Germany.
FAU - Ungureanu, Loredana
AU  - Ungureanu L
AD  - Department of Dermatology, Iuliu Hatieganu University of Medicine and Pharmacy, 
      Cluj-Napoca, Romania.
FAU - Tamayo, Arturo
AU  - Tamayo A
AD  - The Max Rady Faculty of Health Sciences, University of Manitoba and Winnipeg, 
      Brandon Regional Hospital, Winnipeg, MB, Canada.
FAU - Siepmann, Timo
AU  - Siepmann T
AD  - Division of Health Care Sciences, Center for Clinical Research and Management 
      Education, Dresden International University, Dresden, Germany.
AD  - Department of Neurology, University Hospital Carl Gustav Carus, Technische 
      Universitat, Dresden, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200520
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC7251176
OTO - NOTNLM
OT  - DPN
OT  - DPN treatment
OT  - borderline/atypical deep penetrating nevus
OT  - borderline/atypical deep penetrating nevus treatment
OT  - deep penetrating nevus
EDAT- 2020/06/09 06:00
MHDA- 2020/06/09 06:01
PMCR- 2020/01/01
CRDT- 2020/06/09 06:00
PHST- 2020/03/29 00:00 [received]
PHST- 2020/04/28 00:00 [accepted]
PHST- 2020/06/09 06:00 [entrez]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2020/06/09 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2020.00837 [doi]
PST - epublish
SO  - Front Oncol. 2020 May 20;10:837. doi: 10.3389/fonc.2020.00837. eCollection 2020.