PMID- 32509880
OWN - NLM
STAT- MEDLINE
DCOM- 20210405
LR  - 20220414
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - Lactobacillus plantarum And Inulin: Therapeutic Agents to Enhance Cardiac Ob 
      Receptor Expression and Suppress Cardiac Apoptosis in Type 2 Diabetic Rats.
PG  - 4745389
LID - 10.1155/2020/4745389 [doi]
LID - 4745389
AB  - BACKGROUND: T2DM may cause increased levels of oxidative stress and cardiac 
      apoptosis through elevated blood glucose. The present study investigated the 
      effects of Lactobacillus plantarum (L. plantarum) as a probiotic strain and 
      inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic 
      markers in type 2 diabetes mellitus (T2DM) rats. METHODS: A high-fat diet and a 
      low dose of streptozotocin were used to induce type 2 diabetes. The rats were 
      divided into six groups which were supplemented with L. plantarum, inulin, or 
      their combination for 8 weeks. RESULTS: The results showed improved activity of 
      cardiac antioxidant parameters including total antioxidant capacity (TAC), 
      superoxide dismutase (SOD), and glutathione peroxidase (GPx) (P < 0.001, P < 
      0.01, and P < 0.01, respectively) and decreased level of cardiac malondialdehyde 
      (MDA) concentration (P < 0.05). These changes were accompanied with increased 
      protein expression of cardiac obesity receptor (Ob-R) (P = 0.05) and reduced 
      apoptotic markers such as tumor necrosis factor-alpha (TNF-alpha), Fas ligand (FasL), 
      and caspase proteins (P < 0.001, P = 0.003, and P < 0.01, respectively) in T2DM 
      rats after concurrent L. plantarum and inulin supplementation. Moreover, a 
      remarkable correlation of cardiac Ob-R and oxidative stress parameters with 
      cardiac apoptotic markers was observed (P < 0.01). CONCLUSION: The concurrent use 
      of L. plantarum and inulin seems to be beneficial, as they can lead to decreased 
      heart complications of T2DM via reducing cardiac apoptotic markers.
CI  - Copyright (c) 2020 Safa Sefidgari-Abrasi et al.
FAU - Sefidgari-Abrasi, Safa
AU  - Sefidgari-Abrasi S
AUID- ORCID: 0000-0003-2475-9073
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Karimi, Pouran
AU  - Karimi P
AD  - Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Roshangar, Leila
AU  - Roshangar L
AD  - Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Morshedi, Mohammad
AU  - Morshedi M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Bavafa-Valenlia, Khadijeh
AU  - Bavafa-Valenlia K
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Saghafi-Asl, Maryam
AU  - Saghafi-Asl M
AUID- ORCID: 0000-0002-6658-2918
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
AD  - Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Mohiti, Sara
AU  - Mohiti S
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Rahimiyan-Heravan, Marziyeh
AU  - Rahimiyan-Heravan M
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200515
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Blood Glucose)
RN  - 0 (Receptors, Leptin)
RN  - 9005-80-5 (Inulin)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Blood Glucose/drug effects/metabolism
MH  - Diabetes Mellitus, Experimental/*diet therapy/metabolism/pathology
MH  - Diabetes Mellitus, Type 2/diet therapy/metabolism/pathology
MH  - Diabetic Cardiomyopathies/pathology/*prevention & control
MH  - Dietary Supplements
MH  - Heart/drug effects/*physiology
MH  - Inulin/*administration & dosage
MH  - *Lactobacillus plantarum
MH  - Male
MH  - Myocardium/metabolism/pathology
MH  - Oxidative Stress/drug effects
MH  - Probiotics/administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Leptin/*metabolism
PMC - PMC7246403
COIS- The authors declare that they have no competing interests.
EDAT- 2020/06/09 06:00
MHDA- 2021/04/07 06:00
PMCR- 2020/05/15
CRDT- 2020/06/09 06:00
PHST- 2020/01/31 00:00 [received]
PHST- 2020/04/23 00:00 [accepted]
PHST- 2020/06/09 06:00 [entrez]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2020/05/15 00:00 [pmc-release]
AID - 10.1155/2020/4745389 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 May 15;2020:4745389. doi: 10.1155/2020/4745389. eCollection 
      2020.