PMID- 32510220 OWN - NLM STAT- MEDLINE DCOM- 20201112 LR - 20201112 IS - 1520-5851 (Electronic) IS - 0013-936X (Linking) VI - 54 IP - 13 DP - 2020 Jul 7 TI - Does Low Maternal Exposure to Per- and Polyfluoroalkyl Substances Elevate the Risk of Spontaneous Preterm Birth? A Nested Case-Control Study in China. PG - 8259-8268 LID - 10.1021/acs.est.0c01930 [doi] AB - Previous animal and human studies suggest potential links between maternal exposure to per- and polyfluoroalkyl substances (PFASs) and adverse birth outcomes. As spontaneous preterm birth (SPB) represents a major cause of infant mortality and precursor to future morbidity, we conducted a prospective nested case-control study in Shanxi Province, China to investigate the association between prenatal PFAS exposure and SPB risk, as well as the associations with biomarkers of oxidative stress and systemic inflammation. Among 4229 women enrolled during 2009-2013, 144 SPB cases and 375 controls were included in this study. Seventeen PFASs, as well as monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), and heme oxygenase-1 (HO-1), were measured in maternal plasma or serum collected during 4th-22nd gestational weeks. Perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and its alternative chlorinated polyfluoroether sulfonic acid (6:2 Cl-PFESA) were detected in more than 90% samples with a median concentration of 0.79, 1.79, and 0.34 ng/mL, respectively. The analyses revealed no significant associations between plasma PFASs and the SPB risk after adjusting for potential confounders. However, concentrations of PFOS and 6:2 Cl-PFESA were both significantly and positively associated with MCP-1 levels, while PFOA was inversely associated with IL-8. Our findings suggested that maternal exposure to the determined low levels of PFAS did not induce an elevated risk of SPB, but the exposure may disturb potential biochemical pathways of inflammation. The latter has important implications for possible birth outcome effects and developmental effects in fetuses and newborns, which warrants close attention. FAU - Liu, Xiaotu AU - Liu X AUID- ORCID: 0000-0002-3698-019X AD - School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China. FAU - Chen, Da AU - Chen D AUID- ORCID: 0000-0001-5563-0091 AD - School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China. FAU - Wang, Bin AU - Wang B AUID- ORCID: 0000-0002-1164-8430 AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Xu, Fangping AU - Xu F AD - School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China. FAU - Pang, Yiming AU - Pang Y AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Zhang, Le AU - Zhang L AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Zhang, Yali AU - Zhang Y AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Li, Zhiwen AU - Li Z AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Ren, Aiguo AU - Ren A AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200618 PL - United States TA - Environ Sci Technol JT - Environmental science & technology JID - 0213155 RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - *Alkanesulfonic Acids/toxicity MH - Animals MH - Case-Control Studies MH - China/epidemiology MH - *Environmental Pollutants MH - Female MH - *Fluorocarbons/toxicity MH - Humans MH - Infant, Newborn MH - Maternal Exposure/adverse effects MH - Pregnancy MH - *Premature Birth/chemically induced/epidemiology MH - Prospective Studies EDAT- 2020/06/09 06:00 MHDA- 2020/11/13 06:00 CRDT- 2020/06/09 06:00 PHST- 2020/06/09 06:00 [pubmed] PHST- 2020/11/13 06:00 [medline] PHST- 2020/06/09 06:00 [entrez] AID - 10.1021/acs.est.0c01930 [doi] PST - ppublish SO - Environ Sci Technol. 2020 Jul 7;54(13):8259-8268. doi: 10.1021/acs.est.0c01930. Epub 2020 Jun 18.