PMID- 32510754
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20201130
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 34
IP  - 10
DP  - 2020 Oct
TI  - Effect of Nigella sativa oil supplement on risk factors for cardiovascular 
      diseases in patients with type 2 diabetes mellitus.
PG  - 2706-2711
LID - 10.1002/ptr.6707 [doi]
AB  - This study aimed to evaluate the effects of Nigella sativa oil on serum level of 
      systemic inflammation, oxidative stress, fasting blood glucose (FBG), and lipid 
      profile in patients with type 2 diabetes mellitus (T2DM). This double-blind 
      randomized clinical trial study was based on 50 patients with T2DM. Patients were 
      allocated randomly to either N. sativa oil or placebo groups. The intervention 
      group received 1,000 mg N. sativa oil as two capsules, daily for 8 weeks, whereas 
      the placebo group received a corresponding placebo. At baseline and the end of 
      the study, 5 ml blood was collected from each patient after 14-hour fasting for 
      measuring serum C-reactive protein (hs-CRP), malondialdehyde (MDA), FBS, and 
      lipid profile. Analyses covariance was performed to compare investigated 
      parameters between two groups, controlled for relevant covariates. Using N. 
      sativa supplement was significantly associated with decrease in FBS (p < .001), 
      triglyceride (p < .001), total cholesterol (p < .001), low-density lipoprotein 
      cholesterol (p < .001), serum hs-CRP, MDA (p < .001) and increase in serum level 
      of high-density lipoprotein cholesterol (p < .001) in intervention group compared 
      with placebo group. Nigella sativa oil supplement has cardiovascular protective 
      effects in patients with T2DM, by improving the lipid profile and glycemia, by 
      reducing the C-reactive protein level and the lipid peroxidation.
CI  - (c) 2020 John Wiley & Sons, Ltd.
FAU - Kooshki, Akram
AU  - Kooshki A
AD  - Non-Communicable Diseases Research Center, Department of Nutrition & 
      Biochemistry, School of Medicine, Sabzevar University of Medical Sciences, 
      Sabzevar, Iran.
FAU - Tofighiyan, Tahereh
AU  - Tofighiyan T
AD  - Department of Nursing, School of Nursing and Midwifery, Sabzevar University of 
      Medical Sciences, Sabzevar, Iran.
FAU - Rastgoo, Neda
AU  - Rastgoo N
AD  - Department of Internal Medicine, School of Medicine, Sabzevar University of 
      Medical Sciences, Sabzevar, Iran.
FAU - Rakhshani, Mohammad Hassan
AU  - Rakhshani MH
AD  - Iranian Research Center on Healthy Aging, Department of Biostatistics and 
      Epidemiology, School of Health, Sabzevar University of Medical Sciences, 
      Sabzevar, Iran.
FAU - Miri, Mohammad
AU  - Miri M
AUID- ORCID: 0000-0002-9424-6487
AD  - Non-Communicable Diseases Research Center, Department of Environmental Health, 
      School of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200608
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Plant Oils)
RN  - C2J9B08Q3I (caraway oil)
SB  - IM
MH  - Cardiovascular Diseases/*drug therapy
MH  - Diabetes Mellitus, Type 2/*complications/*drug therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plant Oils/*chemistry
MH  - Risk Factors
OTO - NOTNLM
OT  - Nigella sativa
OT  - diabetes
OT  - hs-CRP
OT  - oxidative stress
OT  - serum lipids
EDAT- 2020/06/09 06:00
MHDA- 2020/12/01 06:00
CRDT- 2020/06/09 06:00
PHST- 2019/11/24 00:00 [received]
PHST- 2020/03/23 00:00 [revised]
PHST- 2020/04/07 00:00 [accepted]
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/06/09 06:00 [entrez]
AID - 10.1002/ptr.6707 [doi]
PST - ppublish
SO  - Phytother Res. 2020 Oct;34(10):2706-2711. doi: 10.1002/ptr.6707. Epub 2020 Jun 8.