PMID- 32511025
OWN - NLM
STAT- MEDLINE
DCOM- 20210112
LR  - 20210112
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Linking)
VI  - 17
IP  - 8
DP  - 2020 Aug
TI  - Manufacturing of hybrid drug delivery systems by utilizing the fused filament 
      fabrication (FFF) technology.
PG  - 1063-1068
LID - 10.1080/17425247.2020.1776260 [doi]
AB  - The potential of fused filament fabrication (FFF) for the administration of 
      active pharmaceutical compounds is a recent approach to develop complex and 
      custom-made drug delivery systems (DDSs). However, the FFF technology is 
      characterized by certain limitations, which are associated with the nature of the 
      process, i.e., the required mechanical properties of the feedstock, as well as 
      the thermal stability of the incorporated polymers, excipients and active 
      compounds. Thus, hybrid DDSs have been recently introduced, to overcome these 
      boundaries. The concept of these systems is defined by the effective coupling of 
      FFF with conventional manufacturing technologies, as a novel pathway to expand 
      the available pool of raw materials and pharmaceutical applications of FFF.
FAU - Eleftheriadis, Georgios K
AU  - Eleftheriadis GK
AUID- ORCID: 0000-0001-6111-4376
AD  - Department of Pharmacy, Aristotle University of Thessaloniki , Thessaloniki, 
      Greece.
FAU - Katsiotis, Christos S
AU  - Katsiotis CS
AUID- ORCID: 0000-0002-0154-3627
AD  - Department of Pharmacy, Aristotle University of Thessaloniki , Thessaloniki, 
      Greece.
FAU - Genina, Natalja
AU  - Genina N
AD  - Department of Pharmacy, University of Copenhagen , Copenhagen, Denmark.
FAU - Boetker, Johan
AU  - Boetker J
AD  - Department of Pharmacy, University of Copenhagen , Copenhagen, Denmark.
FAU - Rantanen, Jukka
AU  - Rantanen J
AD  - Department of Pharmacy, University of Copenhagen , Copenhagen, Denmark.
FAU - Fatouros, Dimitrios G
AU  - Fatouros DG
AD  - Department of Pharmacy, Aristotle University of Thessaloniki , Thessaloniki, 
      Greece.
LA  - eng
PT  - Editorial
DEP - 20200608
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - 0 (Excipients)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polymers)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Excipients/chemistry
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Polymers/chemistry
MH  - Printing, Three-Dimensional
MH  - Technology
OTO - NOTNLM
OT  - 3D printing
OT  - automated filling
OT  - biologics
OT  - electrospinning
OT  - fused filament fabrication
OT  - hybrid systems
OT  - injection molding
OT  - inkjet printing
EDAT- 2020/06/09 06:00
MHDA- 2021/01/13 06:00
CRDT- 2020/06/09 06:00
PHST- 2020/06/09 06:00 [pubmed]
PHST- 2021/01/13 06:00 [medline]
PHST- 2020/06/09 06:00 [entrez]
AID - 10.1080/17425247.2020.1776260 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2020 Aug;17(8):1063-1068. doi: 
      10.1080/17425247.2020.1776260. Epub 2020 Jun 8.