PMID- 32513548
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 2211-5684 (Electronic)
IS  - 2211-5684 (Linking)
VI  - 102
IP  - 2
DP  - 2021 Feb
TI  - Differences in right ventricular-pulmonary vascular coupling and clinical indices 
      between repaired standard tetralogy of Fallot and repaired tetralogy of Fallot 
      with pulmonary atresia.
PG  - 85-91
LID - S2211-5684(20)30154-6 [pii]
LID - 10.1016/j.diii.2020.05.008 [doi]
AB  - PURPOSE: The purpose of this study was to compare ventricular vascular coupling 
      ratio (VVCR) between patients with repaired standard tetralogy of Fallot (TOF) 
      and those with repaired TOF-pulmonary atresia (TOF-PA) using cardiovascular 
      magnetic resonance (CMR). MATERIALS AND METHODS: Patients with repaired TOF 
      aged>6 years were prospectively enrolled for same day CMR, echocardiography, and 
      exercise stress test following a standardized protocol. Sanz's method was used to 
      calculate VVCR as right ventricle (RV) end-systolic volume/pulmonary artery 
      stroke volume. Regression analysis was used to examine associations with exercise 
      test parameters, New York Heart Association (NYHA) class, RV size and 
      biventricular systolic function. RESULTS: A total of 248 subjects were included; 
      of these 222 had repaired TOF (group I, 129 males; mean age, 15.9+/-4.7 [SD] years 
      [range: 8-29 years]) and 26 had repaired TOF-PA (group II, 14 males; mean age, 
      17.0+/-6.3 [SD] years [range: 8-29 years]). Mean VVCR for all subjects was 
      1.54+/-0.64 [SD] (range: 0.43-3.80). Mean VVCR was significantly greater in the 
      TOF-PA group (1.81+/-0.75 [SD]; range: 0.78-3.20) than in the standard TOF group 
      (1.51+/-0.72 [SD]; range: 0.43-3.80) (P=0.03). VVCR was greater in the 68 NYHA 
      class II subjects (1.79+/-0.66 [SD]; range: 0.75-3.26) compared to the 179 NYHA 
      class I subjects (1.46+/-0.61 [SD]; range: 0.43-3.80) (P<0.001). CONCLUSION: 
      Non-invasive determination of VVCR using CMR is feasible in children and 
      adolescents. VVCR showed association with NYHA class, and was worse in subjects 
      with repaired TOF-PA compared to those with repaired standard TOF. VVCR shows 
      promise as an indicator of pulmonary artery compliance and cardiovascular 
      performance in this cohort.
CI  - Copyright (c) 2020 Societe francaise de radiologie. Published by Elsevier Masson 
      SAS. All rights reserved.
FAU - Buddhe, S
AU  - Buddhe S
AD  - Division of Pediatric Cardiology, Department of Pediatrics, Seattle Children's 
      Hospital, 91805 Seattle, WA, USA.
FAU - Jani, V
AU  - Jani V
AD  - Blalock Taussig Thomas Heart Center, The Johns Hopkins Hospital and School of 
      Medicine, 1800 Orleans St, 21287 Baltimore, MD, USA.
FAU - Sarikouch, S
AU  - Sarikouch S
AD  - Department of Heart- Thoracic- Transplantation- and Vascular Surgery, Hannover 
      Medical School, 30625 Hannover, Germany.
FAU - Gaur, L
AU  - Gaur L
AD  - Blalock Taussig Thomas Heart Center, The Johns Hopkins Hospital and School of 
      Medicine, 1800 Orleans St, 21287 Baltimore, MD, USA.
FAU - Schuster, A
AU  - Schuster A
AD  - Department of Cardiology and Pneumology, University of Goettingen School of 
      Medicine, 37075 Gottingen, Germany.
FAU - Beerbaum, P
AU  - Beerbaum P
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Hannover Medical 
      School, Hannover Medical School, Hannover, Germany.
FAU - Lewin, M
AU  - Lewin M
AD  - Division of Pediatric Cardiology, Department of Pediatrics, Seattle Children's 
      Hospital, 91805 Seattle, WA, USA.
FAU - Kutty, S
AU  - Kutty S
AD  - Blalock Taussig Thomas Heart Center, The Johns Hopkins Hospital and School of 
      Medicine, 1800 Orleans St, 21287 Baltimore, MD, USA. Electronic address: 
      skutty1@jhmi.edu.
LA  - eng
PT  - Journal Article
DEP - 20200606
PL  - France
TA  - Diagn Interv Imaging
JT  - Diagnostic and interventional imaging
JID - 101568499
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Echocardiography
MH  - *Heart Defects, Congenital
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - *Pulmonary Atresia/diagnostic imaging/surgery
MH  - *Tetralogy of Fallot/diagnostic imaging/surgery
OTO - NOTNLM
OT  - Magnetic resonance imaging
OT  - Pulmonary artery
OT  - Pulmonary atresia
OT  - Right ventricular dysfunction
OT  - Tetralogy of Fallot
EDAT- 2020/06/10 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/06/10 06:00
PHST- 2020/02/20 00:00 [received]
PHST- 2020/05/20 00:00 [revised]
PHST- 2020/05/23 00:00 [accepted]
PHST- 2020/06/10 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/06/10 06:00 [entrez]
AID - S2211-5684(20)30154-6 [pii]
AID - 10.1016/j.diii.2020.05.008 [doi]
PST - ppublish
SO  - Diagn Interv Imaging. 2021 Feb;102(2):85-91. doi: 10.1016/j.diii.2020.05.008. 
      Epub 2020 Jun 6.