PMID- 32514863
OWN - NLM
STAT- MEDLINE
DCOM- 20210607
LR  - 20220724
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 57
IP  - 8
DP  - 2020 Aug
TI  - Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal 
      Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric 
      Comorbidities.
PG  - 3334-3348
LID - 10.1007/s12035-020-01949-8 [doi]
AB  - Oxidative stress toxicity (OSTOX), as well as lowered antioxidant defenses 
      (ANTIOX), plays a role in temporal lobe epilepsy (TLE). Nevertheless, the 
      associations between OSTOX/ANTIOX and psychiatric comorbidities in TLE are 
      largely unknown. Thus, this study examines plasma malondialdehyde (MDA), lipid 
      hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide 
      metabolites (NO(x)), total radical-trapping antioxidant parameter (TRAP), and 
      sulfhydryl (-SH) groups in depression due to TLE (n = 25); anxiety disorders due 
      to TLE (n = 27); psychotic disorder due to TLE (n = 25); "pure TLE" (n = 27); and 
      healthy controls (n = 40). TLE and mesial temporal sclerosis (MTS) were 
      characterized by significant increases in OSTOX (MDA, AOPP, LOOH) and lowered 
      ANTIOX (-SH groups, TRAP). The discrimination of pure TLE from controls yielded a 
      significant area under the ROC curve for MDA (0.999), AOPP (0.851), -SH groups 
      (0.899), and the OSTOX/ANTIOX ratio (0.996). Seizure frequency is significantly 
      associated with increased MDA and lowered LOOH and NO(x) levels. Increased MDA 
      was associated with the severity of depressive and physiosomatic symptoms, while 
      increased AOPP levels predicted suicidal ideation. Depression and anxiety 
      disorders co-occurring with TLE showed significantly lower MDA levels than TLE 
      without any comorbidities. The psychotic and negative symptoms of TLE are 
      associated with increased MDA levels and excitation with increased LOOH and 
      lowered TRAP levels. These results indicate that oxidative stress toxicity 
      especially protein oxidation and aldehyde formation coupled with lowered -SH 
      groups plays a key role in the pathophysiology of TLE/MTS. Increased aldehyde 
      formation also impacts psychopathology and psychosis, as well as negative and 
      depressive symptoms.
FAU - Maes, Michael
AU  - Maes M
AD  - Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial 
      Hospital, Bangkok, Thailand.
AD  - Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.
AD  - IMPACT Strategic Research Center, Deakin University, Geelong, Australia.
FAU - Supasitthumrong, Thitiporn
AU  - Supasitthumrong T
AD  - Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial 
      Hospital, Bangkok, Thailand.
FAU - Limotai, Chusak
AU  - Limotai C
AD  - Chulalongkorn Comprehensive Epilepsy Center of Excellence (CCEC), The Thai Red 
      Cross Society; Division of Neurology, Department of Medicine, Faculty of 
      Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Michelin, Ana Paula
AU  - Michelin AP
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Matsumoto, Andressa Keiko
AU  - Matsumoto AK
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - de Oliveira Semao, Laura
AU  - de Oliveira Semao L
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - de Lima Pedrao, Joao Victor
AU  - de Lima Pedrao JV
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Moreira, Estefania Gastaldello
AU  - Moreira EG
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Carvalho, Andre F
AU  - Carvalho AF
AD  - Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
AD  - Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
FAU - Sirivichayakul, Sunee
AU  - Sirivichayakul S
AD  - Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
FAU - Barbosa, Decio Sabbatini
AU  - Barbosa DS
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Kanchanatawan, Buranee
AU  - Kanchanatawan B
AUID- ORCID: 0000-0002-5387-8867
AD  - Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial 
      Hospital, Bangkok, Thailand. drburanee@gmail.com.
LA  - eng
GR  - RA 57/024/Ratchadapisek Research Fund/
PT  - Journal Article
DEP - 20200609
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Antioxidants)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Antioxidants/*metabolism/pharmacology
MH  - Depressive Disorder, Major/*metabolism/pathology
MH  - Epilepsy, Temporal Lobe/drug therapy/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/metabolism
MH  - Nitrosative Stress/physiology
MH  - Oxidative Stress/*physiology
MH  - Psychotic Disorders/complications/*metabolism
OTO - NOTNLM
OT  - Inflammation
OT  - Major depression
OT  - Neuroimmunomodulation
OT  - Neurotoxicity
OT  - Oxidative stress
OT  - Schizophrenia
OT  - Temporal lobe epilepsy
EDAT- 2020/06/10 06:00
MHDA- 2021/06/08 06:00
CRDT- 2020/06/10 06:00
PHST- 2020/02/02 00:00 [received]
PHST- 2020/05/22 00:00 [accepted]
PHST- 2020/06/10 06:00 [pubmed]
PHST- 2021/06/08 06:00 [medline]
PHST- 2020/06/10 06:00 [entrez]
AID - 10.1007/s12035-020-01949-8 [pii]
AID - 10.1007/s12035-020-01949-8 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2020 Aug;57(8):3334-3348. doi: 10.1007/s12035-020-01949-8. Epub 
      2020 Jun 9.