PMID- 32516129
OWN - NLM
STAT- MEDLINE
DCOM- 20210224
LR  - 20210224
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 12
IP  - 11
DP  - 2020 Jun 9
TI  - How non-drug interventions affect the quality of life of patients suffering from 
      progressive cognitive decline and their main caregiver.
PG  - 10754-10771
LID - 10.18632/aging.103291 [doi]
AB  - BACKGROUND: In the absence of cure for age-related neurodegenerative diseases, 
      non-drug interventions (NDIs) represent useful options. Quality of life (QOL) is 
      a multidimensional concept progressively affected by cognitive decline. How 
      single or multiple NDIs impact QOL is unknown. RESULTS: We found no significant 
      effect of multiple over single NDI on QOL. Socio-demographic variables influenced 
      patients' (age, gender, caregivers' occupational status, management of patients' 
      financial affairs) and caregivers' (gender, occupational status, patients' 
      severity of cognitive decline) QOL. When dyads interrupted interventions after 6 
      months, their QOL was lower and caregivers' anxiety, depression and physical 
      symptoms were higher at the end of the study. CONCLUSIONS: While the type and 
      number of interventions do not appear to be critical, the continuity of adapted 
      interventions in the long-term might be important for maintaining QOL of patients 
      and caregivers. METHODS: This is a multicenter (7 Swiss Memory Clinics), 
      quasi-experimental, one-year follow-up study including 148 subjects (mild 
      cognitive impairment or mild dementia patients and their caregivers). Primary 
      outcome was the effect of multiple vs single NDIs on QOL. Secondary outcome 
      included NDIs effect on patients' cognitive impairment and functional autonomy, 
      caregivers' burden, severity of patients' neuropsychiatric symptoms and dyads' 
      anxiety and depression.
FAU - Leidi-Maimone, Benedetta
AU  - Leidi-Maimone B
AD  - Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, 
      Switzerland.
FAU - Notter-Bielser, Marie-Laure
AU  - Notter-Bielser ML
AD  - Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, 
      Switzerland.
FAU - Laouadi, Marie-Helene
AU  - Laouadi MH
AD  - Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, 
      Switzerland.
FAU - Perrin, Sarah
AU  - Perrin S
AD  - Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, 
      Switzerland.
AD  - Service of Old Age Psychiatry, Department of Psychiatry (SUPAA), Lausanne 
      University Hospital (CHUV), Lausanne, Switzerland.
FAU - Metraux, Helene
AU  - Metraux H
AD  - Vaud Association for Help and Home Care (AVASAD, Association Vaudoise d'Aide et 
      de Soins a Domicile), Lausanne, Switzerland.
FAU - Damian, Daniel
AU  - Damian D
AD  - Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, 
      Switzerland.
FAU - Chavan, Camille F
AU  - Chavan CF
AD  - Memory Center of the Neuropsychology and Aphasiology Unit, Fribourg Hospital 
      (HFR), Fribourg, Switzerland.
FAU - Nsir, Melanie
AU  - Nsir M
AD  - Nord Broye Memory Center, Montagny-pres-Yverdon, Switzerland.
FAU - Cibelli, Gwendoline
AU  - Cibelli G
AD  - East Memory Center of Canton Vaud, Rennaz, Switzerland.
FAU - Tache, Marie-Jo
AU  - Tache MJ
AD  - La Cote Memory Center, Rolle, Switzerland.
FAU - Montandon, Marie-Louise
AU  - Montandon ML
AD  - Memory Center of the Geneva University Hospitals (HUG), Geneva, Switzerland.
AD  - CU ROMENS, Switzerland.
FAU - Ghika, Joseph
AU  - Ghika J
AD  - Valais Hospital Memory Center, Sierre, Switzerland.
FAU - Demonet, Jean-Francois
AU  - Demonet JF
AD  - Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, 
      Switzerland.
AD  - CU ROMENS, Switzerland.
FAU - Durst, Anne-Veronique
AU  - Durst AV
AD  - Service of Geriatric Medicine and Geriatric Rehabilitation, Lausanne University 
      Hospital (CHUV), Lausanne, Switzerland.
FAU - Guevara, Andrea Brioschi
AU  - Guevara AB
AD  - Leenaards Memory Center, Lausanne University Hospital (CHUV), Lausanne, 
      Switzerland.
AD  - CU ROMENS, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200609
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
SB  - IM
MH  - Aged
MH  - Caregivers/*psychology
MH  - Cognitive Dysfunction/*therapy
MH  - Dementia/*therapy
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Neuropsychological Tests
MH  - Psychotherapy
MH  - *Quality of Life
MH  - Switzerland
PMC - PMC7346059
OTO - NOTNLM
OT  - MCI
OT  - caregiver
OT  - dementia
OT  - non-drug intervention
OT  - quality of life
COIS- CONFLICTS OF INTEREST: The authors have no conflicts to declare.
EDAT- 2020/06/10 06:00
MHDA- 2021/02/25 06:00
PMCR- 2020/06/15
CRDT- 2020/06/10 06:00
PHST- 2019/12/17 00:00 [received]
PHST- 2020/04/27 00:00 [accepted]
PHST- 2020/06/10 06:00 [pubmed]
PHST- 2021/02/25 06:00 [medline]
PHST- 2020/06/10 06:00 [entrez]
PHST- 2020/06/15 00:00 [pmc-release]
AID - 103291 [pii]
AID - 10.18632/aging.103291 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2020 Jun 9;12(11):10754-10771. doi: 10.18632/aging.103291. 
      Epub 2020 Jun 9.